AC T02767
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ID T02767
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DT 08.06.1999 (created); mpr.
DT 19.02.2016 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA Nur77
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SY GFRP1; HMR; MGC9485; N10; NAK-1; NAK1; NGFI; NGFI-B; NGFIB; NP10; NR4A1; nuclear receptor subfamily 4, group A, member 1; Nur77; TR3; TR3 orphan receptor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004014 NR4A1; HGNC: NR4A1.
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CL C0002; CC (rec); 2.1.4.0.1.
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SF 86% nucleotide and 91% amino acid sequence homology with mouse NUR77 (suggesting TR3 as the human homologue of mouse NUR77) [2];
SF strong homology with rat NGFI-B [3];
SF hormone-binding domain shares about 20% homology with estrogen receptor and less than 15% homology with other known steroid receptors [2];
SF DNA-binding domain has about 55% homology with other known steroid receptors [2];
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CP fetal muscle, adult liver, brain, thyroid; strong expression in nuclei of glomerulosa cells, low expression in fasciculata cells [5].
CN cells of adrenal capsule, inner medullary cells [5].
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FF mRNA-levels are decreased by all-trans- and 9-cis retinoic acid in MCF-7 cell line [4];
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IN T02872 beta-catenin; human, Homo sapiens.
IN T27154 CHD1L; human, Homo sapiens.
IN T01696 HOXA1; mouse, Mus musculus.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T01486 p107; human, Homo sapiens.
IN T10378 Smad3; human, Homo sapiens.
IN T01493 STAT3; human, Homo sapiens.
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MX M05342 V$NUR77_01.
MX M01217 V$NUR77_Q5.
MX M04622 V$NUR77_Q5_01.
MX M07426 V$NUR77_Q5_02.
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BS R73653.
BS R63893.
BS R20495.
BS R20502.
BS R67661.
BS R40274.
BS R67623.
BS R28188.
BS R68449.
BS R23878.
BS R56128.
BS R67960.
BS R72075.
BS R62855.
BS R62856.
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DR TRANSPATH: MO000026740.
DR UniProtKB: P22736;
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RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013655.
RX PUBMED: 2626032.
RA Chang C., Kokontis J., Liao S. S., Chang Y.
RT Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily
RL J. Steroid Biochem. Mol. Biol. 34:391-395 (1989).
RN [3]; RE0013656.
RX PUBMED: 2283997.
RA Nakai A., Kartha S., Sakurai A., Toback F. G., DeGroot L. J.
RT A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily
RL Mol. Endocrinol. 4:1438-1443 (1990).
RN [4]; RE0016872.
RX PUBMED: 9070291.
RA Maruyama K., Tsukada T., Bandoh S., Sasaki K., Ohkura N., Yamaguchi K.
RT Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7
RL Biochem. Biophys. Res. Commun. 231:417-420 (1997).
RN [5]; RE0041790.
RX PUBMED: 14645496.
RA Bassett M. H., Suzuki T., Sasano H., White P. C., Rainey W. E.
RT The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production
RL Mol. Endocrinol. 18:279-90 (2004).
RN [6]; RE0066497.
RX PUBMED: 19531493.
RA Cottrell G. S., Padilla B. E., Amadesi S., Poole D. P., Murphy J. E., Hardt M., Roosterman D., Steinhoff M., Bunnett N. W.
RT Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
RL J. Biol. Chem. 284:22411-22425 (2009).
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