TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02767 XX ID T02767 XX DT 08.06.1999 (created); mpr. DT 19.02.2016 (updated); jmh. CO Copyright (C), QIAGEN. XX FA Nur77 XX SY GFRP1; HMR; MGC9485; N10; NAK-1; NAK1; NGFI; NGFI-B; NGFIB; NP10; NR4A1; nuclear receptor subfamily 4, group A, member 1; Nur77; TR3; TR3 orphan receptor. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004014 NR4A1; HGNC: NR4A1. XX CL C0002; CC (rec); XX SF 86% nucleotide and 91% amino acid sequence homology with mouse NUR77 (suggesting TR3 as the human homologue of mouse NUR77) [2]; SF strong homology with rat NGFI-B [3]; SF hormone-binding domain shares about 20% homology with estrogen receptor and less than 15% homology with other known steroid receptors [2]; SF DNA-binding domain has about 55% homology with other known steroid receptors [2]; XX CP fetal muscle, adult liver, brain, thyroid; strong expression in nuclei of glomerulosa cells, low expression in fasciculata cells [5]. CN cells of adrenal capsule, inner medullary cells [5]. XX FF mRNA-levels are decreased by all-trans- and 9-cis retinoic acid in MCF-7 cell line [4]; XX IN T02872 beta-catenin; human, Homo sapiens. IN T27154 CHD1L; human, Homo sapiens. IN T01696 HOXA1; mouse, Mus musculus. IN T01925 NF-kappaB1; human, Homo sapiens. IN T01486 p107; human, Homo sapiens. IN T10378 Smad3; human, Homo sapiens. IN T01493 STAT3; human, Homo sapiens. XX MX M05342 V$NUR77_01. MX M01217 V$NUR77_Q5. MX M04622 V$NUR77_Q5_01. MX M07426 V$NUR77_Q5_02. XX BS R73653. BS R63893. BS R20495. BS R20502. BS R67661. BS R40274. BS R67623. BS R28188. BS R68449. BS R23878. BS R56128. BS R67960. BS R72075. BS R62855. BS R62856. XX DR TRANSPATH: MO000026740. DR UniProtKB: P22736; XX RN [1]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [2]; RE0013655. RX PUBMED: 2626032. RA Chang C., Kokontis J., Liao S. S., Chang Y. RT Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily RL J. Steroid Biochem. Mol. Biol. 34:391-395 (1989). RN [3]; RE0013656. RX PUBMED: 2283997. RA Nakai A., Kartha S., Sakurai A., Toback F. G., DeGroot L. J. RT A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily RL Mol. Endocrinol. 4:1438-1443 (1990). RN [4]; RE0016872. RX PUBMED: 9070291. RA Maruyama K., Tsukada T., Bandoh S., Sasaki K., Ohkura N., Yamaguchi K. RT Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7 RL Biochem. Biophys. Res. Commun. 231:417-420 (1997). RN [5]; RE0041790. RX PUBMED: 14645496. RA Bassett M. H., Suzuki T., Sasano H., White P. C., Rainey W. E. RT The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production RL Mol. Endocrinol. 18:279-90 (2004). RN [6]; RE0066497. RX PUBMED: 19531493. RA Cottrell G. S., Padilla B. E., Amadesi S., Poole D. P., Murphy J. E., Hardt M., Roosterman D., Steinhoff M., Bunnett N. W. RT Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. RL J. Biol. Chem. 284:22411-22425 (2009). XX //