TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01486 XX ID T01486 XX DT 08.05.1995 (created); ewi. DT 28.04.2014 (updated); msr. CO Copyright (C), QIAGEN. XX FA p107 XX SY 107 kD retinoblastoma-associated protein; pRB1; Rbl-1; RBL1; Retinoblastoma-like protein 1; retinoblastoma-like protein 1(h). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001063 RBL1; HGNC: RBL1. XX SF regions 2 - 7 are homolog with sequences in the pocket domain of Rb T00722 which allow binding of adenovirus E1A or SV40 T antigen in both Rb and p107 [9]; XX FF interaction with cyclin A:Cdk2 is not required for the inhibitory effect of p107 on E2F transcriptional activity [5]; FF tumor suppressor gene [1]; FF related to Rb [1]; FF involved in cell cycle regulation [2]; FF represses Sp1-dependent transcription [2]; FF acts as a repressor for p107 gene expression via binding to E2F [6]; FF only E2F-4 associates with p107 [7] [10]; XX IN T00140 c-Myc-isoform1; human, Homo sapiens. IN T01488 Cdk2; human, Homo sapiens. IN T01487 cyclinA; human, Homo sapiens. IN T01548 DP-1; human, Homo sapiens. IN T03000 DP-2; human, Homo sapiens. IN T00209 E1A 13S protein; adenovirus type 2. IN T05206 E2F-4:DP-1; human, Homo sapiens. IN T01546 E2F-4; human, Homo sapiens. IN T06087 E2F-5:DP-1; human, Homo sapiens. IN T01607 E2F-5; human, Homo sapiens. IN T00221 E2F:DP; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T25625 hdac2; human, Homo sapiens. IN T04110 HDAC3; human, Homo sapiens. IN T02767 Nur77; human, Homo sapiens. IN T27214 RBBP1; human, Homo sapiens. IN T00759 Sp1; human, Homo sapiens. IN T00788 T-Ag; SV40, simian virus 40. XX BS R01801. BS R25962. BS R39267. XX DR TRANSPATH: MO000011878. DR UniProtKB: P28749; XX RN [1]; RE0002985. RX PUBMED: 1328853. RA Wade M., Kowalik T. F., Mudryj M., Huang E.-S., Azizkhan J. C. RT E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection RL Mol. Cell. Biol. 12:4364-4374 (1992). RN [2]; RE0006767. RX PUBMED: 7565695. RA Datta P. K., Raychaudhuri P., Bagchi S. RT Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription RL Mol. Cell. Biol. 15:5444-5452 (1995). RN [3]; RE0008808. RX PUBMED: 8126000. RA Amin A. A., Murakami Y., Hurwitz J. RT Initiation of DNA replication by simian virus 40 T antigen is inhibited by the p107 protein RL J. Biol. Chem. 269:7735-7742 (1994). RN [4]; RE0009394. RX PUBMED: 8319904. RA Zhu L., van den Heuvel S., Helin K., Fattaey A., Ewen M., Livingston D., Dyson N., Harlow E. RT Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein RL Genes Dev. 7:1111-1125 (1993). RN [5]; RE0010011. RX PUBMED: 7799940. RA Smith E. J., Nevins J. R. RT The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2 RL Mol. Cell. Biol. 15:338-344 (1995). RN [6]; RE0010545. RX PUBMED: 7791762. RA Zhu L., Zhu L., Xie E., Chang L.-S. RT Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins RL Mol. Cell. Biol. 15:3552-3562 (1995). RN [7]; RE0012605. RX PUBMED: 8657117. RA Moberg K., Starz M. A., Lees J. A. RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry RL Mol. Cell. Biol. 16:1436-1449 (1996). RN [8]; RE0013309. RX PUBMED: 2546678. RA Dyson N., Buchkovich K., Whyte P., Harlow E. RT The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. RL Cell 58:249-255 (1989). RN [9]; RE0013310. RX PUBMED: 1833063. RA Ewen M. E., Xing Y. G., Lawrence J. B., Livingston D. M. RT Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. RL Cell 66:1155-1164 (1991). RN [10]; RE0014143. RX PUBMED: 10436023. RA Kohn K. W. RT Molecular interaction map of the mammalian cell cycle control and DNA repair systems RL Mol. Biol. Cell 10:2703-2734 (1999). RN [11]; RE0052309. RX PUBMED: 10490602. RA Lai A., Lee J. M., Yang W. M., DeCaprio J. A., Kaelin WG J. r., Seto E., Branton P. E. RT RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. RL Mol. Cell. Biol. 19:6632-6641 (1999). RN [12]; RE0062791. RX PUBMED: 17698606. RA Tsang W. Y., Wang L., Chen Z., Sanchez I., Dynlacht B. D. RT SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. RL J. Cell Biol. 178:621-633 (2007). XX //