AC T01486
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ID T01486
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DT 08.05.1995 (created); ewi.
DT 28.04.2014 (updated); msr.
CO Copyright (C), QIAGEN.
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FA p107
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SY 107 kD retinoblastoma-associated protein; pRB1; Rbl-1; RBL1; Retinoblastoma-like protein 1; retinoblastoma-like protein 1(h).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001063 RBL1; HGNC: RBL1.
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SF regions 2 - 7 are homolog with sequences in the pocket domain of Rb T00722 which allow binding of adenovirus E1A or SV40 T antigen in both Rb and p107 [9];
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FF interaction with cyclin A:Cdk2 is not required for the inhibitory effect of p107 on E2F transcriptional activity [5];
FF tumor suppressor gene [1];
FF related to Rb [1];
FF involved in cell cycle regulation [2];
FF represses Sp1-dependent transcription [2];
FF acts as a repressor for p107 gene expression via binding to E2F [6];
FF only E2F-4 associates with p107 [7] [10];
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IN T00140 c-Myc-isoform1; human, Homo sapiens.
IN T01488 Cdk2; human, Homo sapiens.
IN T01487 cyclinA; human, Homo sapiens.
IN T01548 DP-1; human, Homo sapiens.
IN T03000 DP-2; human, Homo sapiens.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T05206 E2F-4:DP-1; human, Homo sapiens.
IN T01546 E2F-4; human, Homo sapiens.
IN T06087 E2F-5:DP-1; human, Homo sapiens.
IN T01607 E2F-5; human, Homo sapiens.
IN T00221 E2F:DP; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T25625 hdac2; human, Homo sapiens.
IN T04110 HDAC3; human, Homo sapiens.
IN T02767 Nur77; human, Homo sapiens.
IN T27214 RBBP1; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T00788 T-Ag; SV40, simian virus 40.
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BS R01801.
BS R25962.
BS R39267.
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DR TRANSPATH: MO000011878.
DR UniProtKB: P28749;
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RN [1]; RE0002985.
RX PUBMED: 1328853.
RA Wade M., Kowalik T. F., Mudryj M., Huang E.-S., Azizkhan J. C.
RT E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection
RL Mol. Cell. Biol. 12:4364-4374 (1992).
RN [2]; RE0006767.
RX PUBMED: 7565695.
RA Datta P. K., Raychaudhuri P., Bagchi S.
RT Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
RL Mol. Cell. Biol. 15:5444-5452 (1995).
RN [3]; RE0008808.
RX PUBMED: 8126000.
RA Amin A. A., Murakami Y., Hurwitz J.
RT Initiation of DNA replication by simian virus 40 T antigen is inhibited by the p107 protein
RL J. Biol. Chem. 269:7735-7742 (1994).
RN [4]; RE0009394.
RX PUBMED: 8319904.
RA Zhu L., van den Heuvel S., Helin K., Fattaey A., Ewen M., Livingston D., Dyson N., Harlow E.
RT Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein
RL Genes Dev. 7:1111-1125 (1993).
RN [5]; RE0010011.
RX PUBMED: 7799940.
RA Smith E. J., Nevins J. R.
RT The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2
RL Mol. Cell. Biol. 15:338-344 (1995).
RN [6]; RE0010545.
RX PUBMED: 7791762.
RA Zhu L., Zhu L., Xie E., Chang L.-S.
RT Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins
RL Mol. Cell. Biol. 15:3552-3562 (1995).
RN [7]; RE0012605.
RX PUBMED: 8657117.
RA Moberg K., Starz M. A., Lees J. A.
RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
RL Mol. Cell. Biol. 16:1436-1449 (1996).
RN [8]; RE0013309.
RX PUBMED: 2546678.
RA Dyson N., Buchkovich K., Whyte P., Harlow E.
RT The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.
RL Cell 58:249-255 (1989).
RN [9]; RE0013310.
RX PUBMED: 1833063.
RA Ewen M. E., Xing Y. G., Lawrence J. B., Livingston D. M.
RT Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.
RL Cell 66:1155-1164 (1991).
RN [10]; RE0014143.
RX PUBMED: 10436023.
RA Kohn K. W.
RT Molecular interaction map of the mammalian cell cycle control and DNA repair systems
RL Mol. Biol. Cell 10:2703-2734 (1999).
RN [11]; RE0052309.
RX PUBMED: 10490602.
RA Lai A., Lee J. M., Yang W. M., DeCaprio J. A., Kaelin WG J. r., Seto E., Branton P. E.
RT RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.
RL Mol. Cell. Biol. 19:6632-6641 (1999).
RN [12]; RE0062791.
RX PUBMED: 17698606.
RA Tsang W. Y., Wang L., Chen Z., Sanchez I., Dynlacht B. D.
RT SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.
RL J. Cell Biol. 178:621-633 (2007).
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