TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01607 XX ID T01607 XX DT 29.11.1995 (created); ewi. DT 28.02.2016 (updated); jmh. CO Copyright (C), QIAGEN. XX FA E2F-5 XX SY E2F5. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002971 E2F5; HGNC: E2F5. XX CL C0023; fork head; XX SF no basic region; SF requires heterodimerization with DP-1/2 for efficient DNA-binding and transcriptional activation [2]; SF preferential interaction of E2F-5:DP with p130 in G0 phase, no interaction with Rb [3] [1]; SF prior to crystal structure belongs to bHLH-zip factors [6]; XX CP ubiquitous. XX FF transcriptional activator, E2F-5:DP can stimulate promoters containing E2 elements via a potent transactivation domain in the C-terminal region of the E2F-component [5]; FF transcriptional activation repressed by binding of p107 or p130 [2]; FF transforming potential [2]; FF maximally expressed in mid-G1 and before E2F-1 is detectable [1]; XX IN T01548 DP-1; human, Homo sapiens. IN T01549 DP-1; mouse, Mus musculus. IN T03000 DP-2; human, Homo sapiens. IN T01486 p107; human, Homo sapiens. IN T01608 p130; human, Homo sapiens. XX MX M00050 V$E2F_02. MX M08875 V$E2F_Q4_03. XX BS R05828. BS R05829. BS R05830. BS R05831. BS R05832. BS R05833. BS R05834. BS R05835. BS R05836. BS R05837. BS R05838. BS R05839. BS R04555. BS R24728. BS R71990. BS R71977. XX DR TRANSPATH: MO000004283. DR UniProtKB: Q15329; XX RN [1]; RE0003546. RX PUBMED: 7892279. RA Sardet C., Vidal M., Cobrinik D., Geng Y., Onufryk C., Chen A., Weinberg R. A. RT E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle RL Proc. Natl. Acad. Sci. USA 92:2403-2407 (1995). RN [2]; RE0003547. RX PUBMED: 7760804. RA Hijmans E. M., Voorhoeve P. M., Beijersergen R. L., van't Veer L. J., Bernards R. RT E2F-5, a new E2F family member that interacts with p130 in vivo RL Mol. Cell. Biol. 15:3082-3089 (1995). RN [3]; RE0012605. RX PUBMED: 8657117. RA Moberg K., Starz M. A., Lees J. A. RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry RL Mol. Cell. Biol. 16:1436-1449 (1996). RN [4]; RE0014063. RX PUBMED: 8589754. RA Itoh A., Levinson S. F., Morita T., Kourembanas S., Brody J. S., Mitsialis S. A. RT Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors RL Cell. Mol. Biol. 41:147-154 (1995). RN [5]; RE0014143. RX PUBMED: 10436023. RA Kohn K. W. RT Molecular interaction map of the mammalian cell cycle control and DNA repair systems RL Mol. Biol. Cell 10:2703-2734 (1999). RN [6]; RE0015322. RX PUBMED: 10090723. RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P. RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP RL Genes Dev. 13:666-674 (1999). XX //