AC T01607
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ID T01607
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DT 29.11.1995 (created); ewi.
DT 28.02.2016 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA E2F-5
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SY E2F5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002971 E2F5; HGNC: E2F5.
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CL C0023; fork head; 3.3.2.1.5.
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SF no basic region;
SF requires heterodimerization with DP-1/2 for efficient DNA-binding and transcriptional activation [2];
SF preferential interaction of E2F-5:DP with p130 in G0 phase, no interaction with Rb [3] [1];
SF prior to crystal structure belongs to bHLH-zip factors [6];
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CP ubiquitous.
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FF transcriptional activator, E2F-5:DP can stimulate promoters containing E2 elements via a potent transactivation domain in the C-terminal region of the E2F-component [5];
FF transcriptional activation repressed by binding of p107 or p130 [2];
FF transforming potential [2];
FF maximally expressed in mid-G1 and before E2F-1 is detectable [1];
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IN T01548 DP-1; human, Homo sapiens.
IN T01549 DP-1; mouse, Mus musculus.
IN T03000 DP-2; human, Homo sapiens.
IN T01486 p107; human, Homo sapiens.
IN T01608 p130; human, Homo sapiens.
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MX M00050 V$E2F_02.
MX M08875 V$E2F_Q4_03.
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BS R05828.
BS R05829.
BS R05830.
BS R05831.
BS R05832.
BS R05833.
BS R05834.
BS R05835.
BS R05836.
BS R05837.
BS R05838.
BS R05839.
BS R04555.
BS R24728.
BS R71990.
BS R71977.
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DR TRANSPATH: MO000004283.
DR UniProtKB: Q15329;
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RN [1]; RE0003546.
RX PUBMED: 7892279.
RA Sardet C., Vidal M., Cobrinik D., Geng Y., Onufryk C., Chen A., Weinberg R. A.
RT E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle
RL Proc. Natl. Acad. Sci. USA 92:2403-2407 (1995).
RN [2]; RE0003547.
RX PUBMED: 7760804.
RA Hijmans E. M., Voorhoeve P. M., Beijersergen R. L., van't Veer L. J., Bernards R.
RT E2F-5, a new E2F family member that interacts with p130 in vivo
RL Mol. Cell. Biol. 15:3082-3089 (1995).
RN [3]; RE0012605.
RX PUBMED: 8657117.
RA Moberg K., Starz M. A., Lees J. A.
RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
RL Mol. Cell. Biol. 16:1436-1449 (1996).
RN [4]; RE0014063.
RX PUBMED: 8589754.
RA Itoh A., Levinson S. F., Morita T., Kourembanas S., Brody J. S., Mitsialis S. A.
RT Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors
RL Cell. Mol. Biol. 41:147-154 (1995).
RN [5]; RE0014143.
RX PUBMED: 10436023.
RA Kohn K. W.
RT Molecular interaction map of the mammalian cell cycle control and DNA repair systems
RL Mol. Biol. Cell 10:2703-2734 (1999).
RN [6]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
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