AC T01549
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ID T01549
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DT 07.08.1995 (created); ewi.
DT 17.11.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA DP-1
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SY DRTF1-polypeptide-1; TFDP1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006803 Tfdp1.
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CL C0023; fork head; 3.3.2.2.1.
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SF DP-1 is a component of DRTF1/E2F [5];
SF it heterodimerizes with E2F-components;
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FF no transcriptional activation;
FF in a heterodimeric complex with a E2F-component, it provides high-affinity DNA-binding [1] [2];
FF and contributes to Rb-binding [4];
FF constitutively expressed throughout the cell cycle, but appears to be phosphorylated in a cell cycle-dependent manner [3] [4];
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IN T01542 E2F-1; human, Homo sapiens.
IN T01546 E2F-4; human, Homo sapiens.
IN T01607 E2F-5; human, Homo sapiens.
IN T01806 p53; mouse, Mus musculus.
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MX M00803 V$E2F_Q2.
MX M00918 V$E2F_Q3_01.
MX M00919 V$E2F_Q4_01.
MX M00939 V$E2F_Q4_02.
MX M00920 V$E2F_Q6_01.
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DR TRANSPATH: MO000013459.
DR UniProtKB: Q08639;
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RN [1]; RE0003300.
RX PUBMED: 8248803.
RA Krek W., Livingston D. M., Shirodkar S.
RT Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
RL Science 262:1557-1560 (1993).
RN [2]; RE0003301.
RX PUBMED: 8223441.
RA Bandara L. R., Buck M. V., Zamanian M., Johnston L. H., La Thangue N. B.
RT Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F
RL EMBO J. 12:4317-4324 (1993).
RN [3]; RE0003312.
RX PUBMED: 8206919.
RA Dimri G. P., Hara E., Campisi J.
RT Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
RL J. Biol. Chem. 269:16180-16186 (1994).
RN [4]; RE0003321.
RX PUBMED: 8039504.
RA Bandara L. R., Lam E. W.-L., Sorensen T. S., Zamanian M., Girling R., La Thangue N. B.
RT DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein
RL EMBO J. 13:3104-3114 (1994).
RN [5]; RE0003322.
RX PUBMED: 8446173.
RA Girling R., Partridge J. F., Bandara L. R., Burden N., Totty N. F., Hsuan J. J., La Thangue N. B.
RT A new component of the transcription factor DRTF1/E2F
RL Nature 362:83-87 (1993).
RN [6]; RE0048940.
RX PUBMED: 16135794.
RA Datta A., Sen J., Hagen J., Korgaonkar C. K., Caffrey M., Quelle D. E., Hughes D. E., Ackerson T. J., Costa R. H., Raychaudhuri P.
RT ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.
RL Mol. Cell. Biol. 25:8024-8036 (2005).
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