TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01549 XX ID T01549 XX DT 07.08.1995 (created); ewi. DT 17.11.2014 (updated); jmh. CO Copyright (C), QIAGEN. XX FA DP-1 XX SY DRTF1-polypeptide-1; TFDP1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006803 Tfdp1. XX CL C0023; fork head; XX SF DP-1 is a component of DRTF1/E2F [5]; SF it heterodimerizes with E2F-components; XX FF no transcriptional activation; FF in a heterodimeric complex with a E2F-component, it provides high-affinity DNA-binding [1] [2]; FF and contributes to Rb-binding [4]; FF constitutively expressed throughout the cell cycle, but appears to be phosphorylated in a cell cycle-dependent manner [3] [4]; XX IN T01542 E2F-1; human, Homo sapiens. IN T01546 E2F-4; human, Homo sapiens. IN T01607 E2F-5; human, Homo sapiens. IN T01806 p53; mouse, Mus musculus. XX MX M00803 V$E2F_Q2. MX M00918 V$E2F_Q3_01. MX M00919 V$E2F_Q4_01. MX M00939 V$E2F_Q4_02. MX M00920 V$E2F_Q6_01. XX DR TRANSPATH: MO000013459. DR UniProtKB: Q08639; XX RN [1]; RE0003300. RX PUBMED: 8248803. RA Krek W., Livingston D. M., Shirodkar S. RT Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members RL Science 262:1557-1560 (1993). RN [2]; RE0003301. RX PUBMED: 8223441. RA Bandara L. R., Buck M. V., Zamanian M., Johnston L. H., La Thangue N. B. RT Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F RL EMBO J. 12:4317-4324 (1993). RN [3]; RE0003312. RX PUBMED: 8206919. RA Dimri G. P., Hara E., Campisi J. RT Regulation of two E2F-related genes in presenescent and senescent human fibroblasts RL J. Biol. Chem. 269:16180-16186 (1994). RN [4]; RE0003321. RX PUBMED: 8039504. RA Bandara L. R., Lam E. W.-L., Sorensen T. S., Zamanian M., Girling R., La Thangue N. B. RT DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein RL EMBO J. 13:3104-3114 (1994). RN [5]; RE0003322. RX PUBMED: 8446173. RA Girling R., Partridge J. F., Bandara L. R., Burden N., Totty N. F., Hsuan J. J., La Thangue N. B. RT A new component of the transcription factor DRTF1/E2F RL Nature 362:83-87 (1993). RN [6]; RE0048940. RX PUBMED: 16135794. RA Datta A., Sen J., Hagen J., Korgaonkar C. K., Caffrey M., Quelle D. E., Hughes D. E., Ackerson T. J., Costa R. H., Raychaudhuri P. RT ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF. RL Mol. Cell. Biol. 25:8024-8036 (2005). XX //