AC T03000
XX
ID T03000
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DT 29.02.2000 (created); sth.
DT 22.07.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA DP-2
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SY DKFZp313O196; Dp-2; DP2; FLJ39131; hDP-2; TFDP2; transcription factor Dp-2 (E2F dimerization partner 2).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004549 TFDP2; HGNC: TFDP2.
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CL C0023; fork head; 3.3.2.2.2.
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SF component of the DRTF1/E2F transcription factor complex;
SF high-affinity DNA-binding requires the formation of E2F-DP heterodimers [3];
SF binds cooperatively with E2F's ( 1-5);
SF interacts with retinoblastoma protein RB1 and related proteins (pRb, p107 and p130) that inhibit the E2F transactivation domain;
SF nuclear location [1] [2];
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EX brain,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; high; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; high; Northern blot; mRNA (poly-A); [1].
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FF can stimulate E2F-dependent transcription [1] [2];
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IN T01542 E2F-1; human, Homo sapiens.
IN T09117 E2F-1; human, Homo sapiens.
IN T01544 E2F-2; human, Homo sapiens.
IN T09123 E2F-2; human, Homo sapiens.
IN T14606 E2F-3; human, Homo sapiens.
IN T01546 E2F-4; human, Homo sapiens.
IN T09130 E2F-4; human, Homo sapiens.
IN T01607 E2F-5; human, Homo sapiens.
IN T02997 E2F-6; human, Homo sapiens.
IN T01486 p107; human, Homo sapiens.
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BS R30592.
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DR TRANSPATH: MO000019739.
DR UniProtKB: Q14188;
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RN [1]; RE0010471.
RX PUBMED: 7739537.
RA Wu C.-L., Zukerberg L. R., Ngwu C., Harlow E., Lees J. A.
RT In vivo association of E2F and DP family proteins
RL Mol. Cell. Biol. 15:2536-2546 (1995).
RN [2]; RE0013204.
RX PUBMED: 8755520.
RA Rogers K. T., Higgins P. D. R., Milla M. M., Phillips R. S., Horowitz J. M.
RT DP-2, a heterodimeric partner of E2F: Identification and characterization of DP-2 proteins expressed in vivo
RL Proc. Natl. Acad. Sci. USA 93:7594-7599 (1996).
RN [3]; RE0014135.
RX PUBMED: 9689056.
RA Gaubatz S., Wood J. G., Livingston D. M.
RT Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.
RL Proc. Natl. Acad. Sci. USA 95:9190-9195 (1998).
RN [4]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
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