AC T09130
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ID T09130
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DT 27.07.2006 (created); man.
DT 25.05.2016 (updated); nes.
CO Copyright (C), QIAGEN.
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FA E2F-4
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SY E2F transcription factor 4, p107/p130-binding; E2F-4; E2F4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002038 E2F4; HGNC: E2F4.
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CL C0023; fork head.
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SZ 413 AA; 44.0 kDa (cDNA) (calc.), 60 kDa (SDS) [2]
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SQ MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYD
SQ ITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVW
SQ VQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQ
SQ IHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEAS
SQ RPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQ
SQ SSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTSFEPIKADPTGVLELPKELSEIFDPTR
SQ ECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL
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SC translated from EMBL #U156411
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FT 17 83 
PF02319; E2F/DP family winged-helix DNA-binding domai.
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IN T01548 DP-1; human, Homo sapiens.
IN T03000 DP-2; human, Homo sapiens.
IN T01608 p130; human, Homo sapiens.
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MX M07380 V$E2F4_Q3.
MX M02090 V$E2F4_Q6.
MX M08875 V$E2F_Q4_03.
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BS R25908.
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DR TRANSPATH: MO000083716.
DR EMBL: U15641; HS156411.
DR UniProtKB: Q16254;
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RN [1]; RE0003317.
RX PUBMED: 7958924.
RA Ginsberg D., Vairo G., Chittenden T., Xiao Z.-X., Xu G., Wydner K. L., DeCaprio J. A., Lawrence J. B., Livingston D. M.
RT E2F-4, a new member of the E2F transcription factor family, interacts with p107
RL Genes Dev. 8:2665-2679 (1994).
RN [2]; RE0003318.
RX PUBMED: 7958925.
RA Beijersbergen R. L., Kerkhoven R. M., Zhu L., Carlee L., Voorhoeve P. M., Bernards R.
RT E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
RL Genes Dev. 8:2680-2690 (1994).
RN [3]; RE0003319.
RX PUBMED: 8321204.
RA Chittenden T., Livingston D. M., DeCaprio J. A.
RT Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F
RL Mol. Cell. Biol. 13:3975-3983 (1993).
RN [4]; RE0003546.
RX PUBMED: 7892279.
RA Sardet C., Vidal M., Cobrinik D., Geng Y., Onufryk C., Chen A., Weinberg R. A.
RT E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle
RL Proc. Natl. Acad. Sci. USA 92:2403-2407 (1995).
RN [5]; RE0010381.
RX PUBMED: 7705662.
RA Vairo G., Livingston D. M., Ginsberg D.
RT Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth supression by different retinoblastoma protein family members
RL Genes Dev. 9:869-881 (1995).
RN [6]; RE0011851.
RX PUBMED: 8524257.
RA Tommasi S., Pfeifer G. P.
RT In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression
RL Mol. Cell. Biol. 15:6901-6913 (1995).
RN [7]; RE0012605.
RX PUBMED: 8657117.
RA Moberg K., Starz M. A., Lees J. A.
RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
RL Mol. Cell. Biol. 16:1436-1449 (1996).
RN [8]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
RN [9]; RE0015951.
RX PUBMED: 10983977.
RA Rempel R. E., Saenz-Robles M. T., Storms R., Morham S., Ishida S., Engel A., Jakoi L., Melhem M. F., Pipas J. M., Smith C., Nevins J. R.
RT Loss of E2F4 activity leads to abnormal development of multiple cellular lineages.
RL Mol. Cell 6:293-306 (2000).
RN [10]; RE0031299.
RX PUBMED: 12411495.
RA Schlisio S., Halperin T., Vidal M., Nevins J. R.
RT Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.
RL EMBO J. 21:5775-86 (2002).
RN [11]; RE0054737.
RX PUBMED: 16512785.
RA Kherrouche Z., Blais A., Ferreira E., de Launoit Y., Monte D.
RT ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene.
RL Biochem. J. 396:547-556 (2006).
RN [12]; RE0055135.
RX PUBMED: 18542057.
RA Araki K., Kawauchi K., Tanaka N.
RT IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.
RL Oncogene 27:5696-5705 (2008).
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