TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01608 XX ID T01608 XX DT 29.11.1995 (created); ewi. DT 09.07.2014 (updated); mkl. CO Copyright (C), QIAGEN. XX FA p130 XX SY 130 kD retinoblastoma-associated protein; pRb2; Rb2; RBL2; Rbr-2; retinoblastoma-associated protein 2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004606 RBL2; HGNC: RBL2. XX SF interaction with factors containing paired-like homeodomains [4]; SF E2F-4 and -5 associate with p130 in T-cell G0 phase [3]; XX FF expression of p130 in hamster HJC12 cells in reduces the kinase activity of cyclin A:Cdk2 and cyclin E:Cdk2 complexes but increases cyclin D-associated enzymatic activity [6]; FF p130 down-regulates cyclin A and E2F-1 expression in HJC12 cells and up-regulates p27Kip1 and cyclin E [6]; XX IN T02967 Alx-4; mouse, Mus musculus. IN T01488 Cdk2; human, Homo sapiens. IN T02970 CHX10; mouse, Mus musculus. IN T01487 cyclinA; human, Homo sapiens. IN T05206 E2F-4:DP-1; human, Homo sapiens. IN T01546 E2F-4; human, Homo sapiens. IN T09130 E2F-4; human, Homo sapiens. IN T06087 E2F-5:DP-1; human, Homo sapiens. IN T01607 E2F-5; human, Homo sapiens. IN T21852 HDAC1; Mammalia. IN T17035 LIN-9; human, Homo sapiens. IN T00680 Pax-3; mouse, Mus musculus. IN T06377 PML; human, Homo sapiens. IN T02966 PMX1; mouse, Mus musculus. IN T27214 RBBP1; human, Homo sapiens. IN T00788 T-Ag; SV40, simian virus 40. XX DR TRANSPATH: MO000011881. DR UniProtKB: Q08999; XX RN [1]; RE0008292. RX PUBMED: 8253384. RA Hannon G. J., Demetrick D., Beach D. RT Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins RL Genes Dev. 7:2378-2391 (1993). RN [2]; RE0008294. RX PUBMED: 8253383. RA Li Y., Graham C., Lacy S., Duncan A. M. V., Whyte P. RT The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E RL Genes Dev. 7:2366-2377 (1993). RN [3]; RE0012605. RX PUBMED: 8657117. RA Moberg K., Starz M. A., Lees J. A. RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry RL Mol. Cell. Biol. 16:1436-1449 (1996). RN [4]; RE0014085. RX PUBMED: 9464541. RA Wiggan O., Taniguchi-Sidle A., Hamel P. A. RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains RL Oncogene 16:227-236 (1998). RN [5]; RE0019196. RX PUBMED: 8361765. RA MAYOL X., GRANA X., BALDI A., SANG N., HU Q., GIORDANO A. RT Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. RL Oncogene 8:2561-2566 (1993). RN [6]; RE0021237. RX PUBMED: 10825149. RA Howard C. M., Claudio P. P., de Luca A., Stiegler P., Jori F. P., Safdar N. M., Caputi M., Khalili K., Giordano A. RT Inducible pRb2/p130 expression and growth-suppressive mechanisms: evidence of a pRb2/p130, p27Kip1, and cyclin E negative feedback regulatory loop RL Cancer Res. 60:2737-2744 (2000). RN [7]; RE0047542. RX PUBMED: 9724731. RA Ferreira R., Magnaghi-Jaulin L., Robin P., Harel-Bellan A., Trouche D. RT The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. RL Proc. Natl. Acad. Sci. USA 95:10493-10498 (1998). RN [8]; RE0052309. RX PUBMED: 10490602. RA Lai A., Lee J. M., Yang W. M., DeCaprio J. A., Kaelin WG J. r., Seto E., Branton P. E. RT RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. RL Mol. Cell. Biol. 19:6632-6641 (1999). RN [9]; RE0055135. RX PUBMED: 18542057. RA Araki K., Kawauchi K., Tanaka N. RT IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors. RL Oncogene 27:5696-5705 (2008). XX //