TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02966 XX ID T02966 XX DT 16.02.2000 (created); rio. DT 30.12.2011 (updated); grs. CO Copyright (C), QIAGEN. XX FA PMX1 XX SY MHox; Paired-like homeobox; Phox-1; Pmx; Prrx1; PRX-1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014322 Prrx1. XX CL C0006; homeo; XX SF two splice variants, primarily designated as K-2a T02060 and K-2b T02061 [2]; SF homeo domain most similar to that of S8 (97% identity), suggested to constitute an own subclass of paired-type homeo domains [2]; SF interaction with pRB-family proteins (pRB, p107, p130) mediated by helix I and helix II of the homeodomain [3]; XX CP embryo: mesenchymal cells in craniofacial, pericardial, primitive dermal, prevertebral, and genital structures [2], visceral arch, limb bud [1]; adult: heart, skeletal muscle, uterus [1] [1] [2]. CN intestine, kidney, liver, pancreas, spleen, stomach [1]. XX FF expression during embryogenesis is restricted to mesodermal cell types, highest levels in limb buds and visceral arches [1]; FF overexpression of PMX1 transactivate SM alpha actin gene transcription [4]; XX IN T02971 p107; mouse, Mus musculus. IN T01608 p130; human, Homo sapiens. IN T02972 p130; mouse, Mus musculus. IN T01423 pRb; mouse, Mus musculus. IN T14088 Sox-8; mouse, Mus musculus. XX MX M01348 V$K2B_01. MX M03560 V$PMX1_Q6. XX BS R26224. BS R36223. BS R36231. BS R32463. BS R14885. XX DR TRANSPATH: MO000026919. DR EMBL: L06502; MMMHOX. DR EMBL: X59725; MMHOBOXG. DR EMBL: X59726; MMK2BMR. DR UniProtKB: P63013; XX RN [1]; RE0005123. RX PUBMED: 1360403. RA Cserjesi P., Lilly B., Bryson L. J., Wang Y., Sassoon D. A., Olson E. N. RT MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer RL Development 115:1087-1101 (1992). RN [2]; RE0005125. RX PUBMED: 1383943. RA Kern M. J., Witte D. P., Valerius M. T., Aronow B. J., Potter S. S. RT A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy RL Nucleic Acids Res. 20:5189-5195 (1992). RN [3]; RE0014085. RX PUBMED: 9464541. RA Wiggan O., Taniguchi-Sidle A., Hamel P. A. RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains RL Oncogene 16:227-236 (1998). RN [4]; RE0024194. RX PUBMED: 9314842. RA Hautmann M. B., Thompson M. M., Swartz E. A., Olson E. N., Owens G. K. RT Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox. RL Circ. Res. 81:600-610 (1997). RN [5]; RE0048308. RX PUBMED: 16582099. RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M. RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. RL Nucleic Acids Res. 34:1735-1744 (2006). XX //