AC T02966
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ID T02966
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DT 16.02.2000 (created); rio.
DT 30.12.2011 (updated); grs.
CO Copyright (C), QIAGEN.
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FA PMX1
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SY MHox; Paired-like homeobox; Phox-1; Pmx; Prrx1; PRX-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014322 Prrx1.
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CL C0006; homeo; 3.1.3.21.1.
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SF two splice variants, primarily designated as K-2a T02060 and K-2b T02061 [2];
SF homeo domain most similar to that of S8 (97% identity), suggested to constitute an own subclass of paired-type homeo domains [2];
SF interaction with pRB-family proteins (pRB, p107, p130) mediated by helix I and helix II of the homeodomain [3];
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CP embryo: mesenchymal cells in craniofacial, pericardial, primitive dermal, prevertebral, and genital structures [2], visceral arch, limb bud [1]; adult: heart, skeletal muscle, uterus [1] [1] [2].
CN intestine, kidney, liver, pancreas, spleen, stomach [1].
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FF expression during embryogenesis is restricted to mesodermal cell types, highest levels in limb buds and visceral arches [1];
FF overexpression of PMX1 transactivate SM alpha actin gene transcription [4];
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IN T02971 p107; mouse, Mus musculus.
IN T01608 p130; human, Homo sapiens.
IN T02972 p130; mouse, Mus musculus.
IN T01423 pRb; mouse, Mus musculus.
IN T14088 Sox-8; mouse, Mus musculus.
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MX M01348 V$K2B_01.
MX M03560 V$PMX1_Q6.
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BS R26224.
BS R36223.
BS R36231.
BS R32463.
BS R14885.
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DR TRANSPATH: MO000026919.
DR EMBL: L06502; MMMHOX.
DR EMBL: X59725; MMHOBOXG.
DR EMBL: X59726; MMK2BMR.
DR UniProtKB: P63013;
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RN [1]; RE0005123.
RX PUBMED: 1360403.
RA Cserjesi P., Lilly B., Bryson L. J., Wang Y., Sassoon D. A., Olson E. N.
RT MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer
RL Development 115:1087-1101 (1992).
RN [2]; RE0005125.
RX PUBMED: 1383943.
RA Kern M. J., Witte D. P., Valerius M. T., Aronow B. J., Potter S. S.
RT A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy
RL Nucleic Acids Res. 20:5189-5195 (1992).
RN [3]; RE0014085.
RX PUBMED: 9464541.
RA Wiggan O., Taniguchi-Sidle A., Hamel P. A.
RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains
RL Oncogene 16:227-236 (1998).
RN [4]; RE0024194.
RX PUBMED: 9314842.
RA Hautmann M. B., Thompson M. M., Swartz E. A., Olson E. N., Owens G. K.
RT Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox.
RL Circ. Res. 81:600-610 (1997).
RN [5]; RE0048308.
RX PUBMED: 16582099.
RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
RL Nucleic Acids Res. 34:1735-1744 (2006).
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