AC T01423
XX
ID T01423
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DT 03.04.1995 (created); ewi.
DT 24.07.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA pRb
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SY pp105; RB; RB-1; RB1; retinoblastoma-associated protein.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004727 Rb1.
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SF interaction with factors containing paired-like homeodomains [2];
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IN T02967 Alx-4; mouse, Mus musculus.
IN T02970 CHX10; mouse, Mus musculus.
IN T00198 DRTF1; mouse, Mus musculus.
IN T09117 E2F-1; human, Homo sapiens.
IN T09191 E2F-3; mouse, Mus musculus.
IN T00526 MyoD; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
IN T00680 Pax-3; mouse, Mus musculus.
IN T00681 Pax-6; mouse, Mus musculus.
IN T02966 PMX1; mouse, Mus musculus.
IN T01490 RBP60; mouse, Mus musculus.
IN T04358 TBX2; mouse, Mus musculus.
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BS R00326.
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DR TRANSPATH: MO000011893.
DR UniProtKB: P13405;
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RN [1]; RE0002872.
RX PUBMED: 1834460.
RA Partridge J. F., La Thangue N. B.
RT A developmentally regulated and tissue-dependent transcription factor complexes with the retinoblastoma gene product
RL EMBO J. 10:3819-3827 (1991).
RN [2]; RE0014085.
RX PUBMED: 9464541.
RA Wiggan O., Taniguchi-Sidle A., Hamel P. A.
RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains
RL Oncogene 16:227-236 (1998).
RN [3]; RE0019198.
RX PUBMED: 2671991.
RA BERNARDS R., SCHACKLEFORD G.M., GERBER M.R., HOROWITZ J.M., FRIEND S.H., SCHARTL M., BOGENMANN E., RAPAPORT J., MCGEE T., DRYJA T., WEINBERG R.A.
RT Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.
RL Proc. Natl. Acad. Sci. USA 86:6474-6478 (1989).
RN [4]; RE0032033.
RX PUBMED: 12757710.
RA Iakova P., Awad S. S., Timchenko N. A.
RT Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.
RL Cell 113:495-506 (2003).
RN [5]; RE0042688.
RX PUBMED: 11684017.
RA Wang H., Iakova P., Wilde M., Welm A., Goode T., Roesler W. J., Timchenko N. A.
RT C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
RL Mol. Cell 8:817-28 (2001).
RN [6]; RE0048297.
RX PUBMED: 10359315.
RA Cvekl A., Kashanchi F., Brady J. N., Piatigorsky J.
RT Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein.
RL Invest. Ophthalmol. Vis. Sci. 40:1343-1350 (1999).
RN [7]; RE0049630.
RX PUBMED: 16374512.
RA Markham D., Munro S., Soloway J., O'Connor D. P., La Thangue N. B.
RT DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
RL EMBO Rep. 7:192-198 (2006).
RN [8]; RE0051076.
RX PUBMED: 16091739.
RA Xiao H., Goodrich D. W.
RT The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes.
RL Oncogene 24:8105-8113 (2005).
RN [9]; RE0052873.
RX PUBMED: 17699765.
RA Landis M. W., Brown N. E., Baker G. L., Shifrin A., Das M., Geng Y., Sicinski P., Hinds P. W.
RT The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.
RL Cancer Res. 67:7613-7620 (2007).
RN [10]; RE0055583.
RX PUBMED: 18700973.
RA Young C. D., Nolte E. C., Lewis A., Serkova N. J., Anderson S. M.
RT Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.
RL Breast Cancer Res. 10:R70 (2008).
RN [11]; RE0055586.
RX PUBMED: 18823499.
RA Park J. H., Lee M. Y., Heo J. S., Han H. J.
RT A potential role of connexin 43 in epidermal growth factor-induced proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC, p44/42 and p38 MAPKs pathways.
RL Cell Prolif. 41:786-802 (2008).
RN [12]; RE0065746.
RX PUBMED: 16809760.
RA de la Fuente M. A., Kumar L., Lu B., Geha R. S.
RT 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
RL Mol. Cell. Biol. 26:5214-5225 (2006).
RN [13]; RE0065991.
RX PUBMED: 20016602.
RA Chong J. L., Wenzel P. L., Saenz-Robles M. T., Nair V., Ferrey A., Hagan J. P., Gomez Y. M., Sharma N., Chen H. Z., Ouseph M., Wang S. H., Trikha P., Culp B., Mezache L., Winton D. J., Sansom O. J., Chen D., Bremner R., Cantalupo P. G., Robinson M. L., Pipas J. M., Leone G.
RT E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.
RL Nature 462:930-934 (2009).
RN [14]; RE0066667.
RX PUBMED: 12077355.
RA Reichelt J., Magin T. M.
RT Hyperproliferation, induction of c-Myc and 14-3-3sigma, but no cell fragility in keratin-10-null mice.
RL J. Cell Sci. 115:2639-2650 (2002).
RN [15]; RE0069640.
RX PUBMED: 18849980.
RA Naetar N., Korbei B., Kozlov S., Kerenyi M. A., Dorner D., Kral R., Gotic I., Fuchs P., Cohen T. V., Bittner R., Stewart C. L., Foisner R.
RT Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.
RL Nat. Cell Biol. 10:1341-1348 (2008).
RN [16]; RE0070917.
RX PUBMED: 20534814.
RA Vance K. W., Shaw H. M., Rodriguez M., Ott S., Goding C. R.
RT The retinoblastoma protein modulates Tbx2 functional specificity.
RL Mol. Biol. Cell 21:2770-2779 (2010).
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