AC T02967
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ID T02967
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DT 17.02.2000 (created); rio.
DT 30.10.2006 (updated); jay.
CO Copyright (C), QIAGEN.
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FA Alx-4
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SY aristaless homeobox like 4; B2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002045 Alx4.
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CL C0006; homeo; 3.1.3.1.3.
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SF two proteins of different molecular masses (42.9/41.3 kDa) due to an alternative initiation codon [2];
SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [3];
SF interaction with pRB-family proteins (pRB, p107, p130) mediated by helix I and helix II of the homeodomain [1];
SF homozygous knockout mice possess ventral body wall defects, decreased size of the parietal plate of the skull and preaxial polydactyly [5];
SF can bind as monomer, dimer or heterodimer with the structural and functional related factor Cart-1 T03999 [4];
SF Alx-4/Cart-1 T03999 double mutants possess an exacerbated polydactyly, additional craniofacial defects and sternal abnormalities [4];
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EX body wall mesenchyme,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX craniofacial region,mesenchyme cell,,Theiler Stage 16; high; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX craniofacial region,mesenchyme cell,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX craniofacial region,mesenchyme cell,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX first pharyngeal arch,mesenchyme cell,,Theiler Stage 16; high; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX first pharyngeal arch,mesenchyme cell,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX first pharyngeal arch,mesenchyme cell,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX forelimb bud,mesenchyme cell,,Theiler Stage 16; high; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX forelimb bud,mesenchyme cell,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX forelimb bud,mesenchyme cell,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX future craniofacial region,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX future mesencephalon,,,Theiler Stage 13; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX future prosencephalon,,,Theiler Stage 13; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX genital tubercle,,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX hindlimb bud,mesenchyme cell,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX hindlimb bud,mesenchyme cell,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX umbilical artery,,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX umbilical vein,,,Theiler Stage 19; low; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
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FF may play a role in the patterning of structures derived from craniofacial mesenchyme [2] [5];
FF anterior-posterior patterning of the limbs [5];
FF polydactyly is associated with the formation of an ectopic anterior ZPA (zone of polarizing activity), so Alx-4 restricts ZPA formation to the posterior limb bud mesenchyme [5];
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IN T02971 p107; mouse, Mus musculus.
IN T01608 p130; human, Homo sapiens.
IN T02972 p130; mouse, Mus musculus.
IN T01423 pRb; mouse, Mus musculus.
IN T08441 Sox-10; rat, Rattus norvegicus.
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MX M00619 V$ALX4_01.
MX M01417 V$ALX4_02.
MX M02944 V$ALX4_03.
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DR TRANSPATH: MO000026920.
DR UniProtKB: O35137;
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RN [1]; RE0014085.
RX PUBMED: 9464541.
RA Wiggan O., Taniguchi-Sidle A., Hamel P. A.
RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains
RL Oncogene 16:227-236 (1998).
RN [2]; RE0014092.
RX PUBMED: 9426253.
RA Qu S., Li L., Wisdom R.
RT Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein
RL Gene 203:217-223 (1997).
RN [3]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [4]; RE0015370.
RX PUBMED: 9847249.
RA Qu S., Tucker S. C., Zhao Q., deCrombrugghe B., Wisdom R.
RT Physical and genetic interactions between Alx4 and Cart1
RL Development 126:359-369 (1999).
RN [5]; RE0015371.
RX PUBMED: 9374397.
RA Qu S., Niswender K. D., Ji Q., van der Meer R., Keeney D., Magnuson M. A., Wisdom R.
RT Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
RL Development 124:3999-4008 (1997).
RN [6]; RE0048308.
RX PUBMED: 16582099.
RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
RL Nucleic Acids Res. 34:1735-1744 (2006).
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