TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03999 XX ID T03999 XX DT 08.11.2000 (created); rio. DT 07.04.2009 (updated); pum. CO Copyright (C), QIAGEN. XX FA CART1 XX SY Alx1; cartilage homeoprotein 1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002020 Alx1. XX CL C0006; homeo; XX SF homozygous knockout mice are born with severe craniofacial defects (acrania, meroanencephaly) and die within 24h of birth [1]; SF folic acid can suppress the knockout phenotype [1]; SF can bind as monomer, dimer or heterodimer with the structural and functional related factor Alx-4 T02967 [2]; SF CART1/Alx-4 T02967 double mutants possess an exacerbated polydactyly, additional craniofacial defects and sternal abnormalities [2]; XX CP (embryo 8.5-9.5 days:) forebrain head mesenchyme, (embryo 9.5 days:) frontonasal mass, mesenchyme surrounding the optic vesicles [1]. XX FF required for forebrain mesenchyme survival and initiation of neural tube closure in the midbrain region [1]; XX MX M04283 V$ALX1_05. MX M00416 V$CART1_01. MX M01362 V$CART1_02. MX M01453 V$CART1_03. XX BS R09589. BS R09590. BS R09591. BS R09592. BS R09593. XX DR TRANSPATH: MO000027909. DR UniProtKB: Q8C8B0; XX RN [1]; RE0015276. RX PUBMED: 8673125. RA Zhao Q., Behringer R. R., de Crombrugghe B. RT Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene RL Nat. Genet. 13:275-283 (1996). RN [2]; RE0015370. RX PUBMED: 9847249. RA Qu S., Tucker S. C., Zhao Q., deCrombrugghe B., Wisdom R. RT Physical and genetic interactions between Alx4 and Cart1 RL Development 126:359-369 (1999). XX //