AC T03999
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ID T03999
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DT 08.11.2000 (created); rio.
DT 07.04.2009 (updated); pum.
CO Copyright (C), QIAGEN.
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FA CART1
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SY Alx1; cartilage homeoprotein 1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002020 Alx1.
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CL C0006; homeo; 3.1.3.1.1.
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SF homozygous knockout mice are born with severe craniofacial defects (acrania, meroanencephaly) and die within 24h of birth [1];
SF folic acid can suppress the knockout phenotype [1];
SF can bind as monomer, dimer or heterodimer with the structural and functional related factor Alx-4 T02967 [2];
SF CART1/Alx-4 T02967 double mutants possess an exacerbated polydactyly, additional craniofacial defects and sternal abnormalities [2];
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CP (embryo 8.5-9.5 days:) forebrain head mesenchyme, (embryo 9.5 days:) frontonasal mass, mesenchyme surrounding the optic vesicles [1].
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FF required for forebrain mesenchyme survival and initiation of neural tube closure in the midbrain region [1];
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MX M04283 V$ALX1_05.
MX M00416 V$CART1_01.
MX M01362 V$CART1_02.
MX M01453 V$CART1_03.
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BS R09589.
BS R09590.
BS R09591.
BS R09592.
BS R09593.
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DR TRANSPATH: MO000027909.
DR UniProtKB: Q8C8B0;
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RN [1]; RE0015276.
RX PUBMED: 8673125.
RA Zhao Q., Behringer R. R., de Crombrugghe B.
RT Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene
RL Nat. Genet. 13:275-283 (1996).
RN [2]; RE0015370.
RX PUBMED: 9847249.
RA Qu S., Tucker S. C., Zhao Q., deCrombrugghe B., Wisdom R.
RT Physical and genetic interactions between Alx4 and Cart1
RL Development 126:359-369 (1999).
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