TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04358 XX ID T04358 XX DT 26.02.2001 (created); rio. DT 04.07.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA TBX2 XX SY T-box protein 2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002676 Tbx2. XX CL C0044; T-box; XX SF binds to the brachyury consensus [2]; XX CP (E9.5:) posterior forelimb bud margin, (E10.5-11.5:) fore-/hindlimb bud mesenchyme, apical ectodermal ridge (AER), (E12.5-13.5:) mesenchyme surrounding digit V, AER [1]; melanocyte cell lines [2] [1] [2]. XX FF involved in limb morphogenesis [1]; FF may be involved in zone of polarizing (ZPA) induction [1]; FF repressor of TRP-1 (tyrosinease-related protein 1) expression [2]; FF USF-1 T00877 and Mitf T01554 can activate expression of TBX2 in melanocytes [3]; FF complementary expression pattern of TBX2 and Tbx3 T04359 in the limbs: TBX2 is expressed in the mesenchyme immediately underlying the posterior half of the apical ectodermal ridge (AER) whereas Tbx3 T04359 is expressed throughout the distal AER [1]; XX IN T01423 pRb; mouse, Mus musculus. XX MX M08900 V$TBX2RELATED_Q6. MX M05388 V$TBX2_04. MX M03889 V$TBX2_Q2. MX M08831 V$TBX2_Q5. XX BS R15796. BS R30662. BS R24615. BS R73849. BS R69896. BS R69898. BS R69899. XX DR TRANSPATH: MO000028216. DR UniProtKB: Q60707; XX RN [1]; RE0015803. RX PUBMED: 8798150. RA Gibson-Brown J. J., Agulnik S. I., Chapman D. L., Alexiou M., Garvey N., Silver L. M., Papaioannou V. E. RT Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity RL Mech. Dev. 56:93-101 (1996). RN [2]; RE0016860. RX PUBMED: 9710594. RA Carreira S., Dexter T. J., Yavuzer U., Easty D. J., Goding C. R. RT Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter RL Mol. Cell. Biol. 18:5099-5108 (1998). RN [3]; RE0016864. RX PUBMED: 10770922. RA Carreira S., Liu B., Goding C. R. RT The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes RL J. Biol. Chem. 275:21920-21927 (2000). RN [4]; RE0070917. RX PUBMED: 20534814. RA Vance K. W., Shaw H. M., Rodriguez M., Ott S., Goding C. R. RT The retinoblastoma protein modulates Tbx2 functional specificity. RL Mol. Biol. Cell 21:2770-2779 (2010). XX //