AC T04358
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ID T04358
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DT 26.02.2001 (created); rio.
DT 04.07.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA TBX2
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SY T-box protein 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002676 Tbx2.
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CL C0044; T-box; 6.5.4.0.1.
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SF binds to the brachyury consensus [2];
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CP (E9.5:) posterior forelimb bud margin, (E10.5-11.5:) fore-/hindlimb bud mesenchyme, apical ectodermal ridge (AER), (E12.5-13.5:) mesenchyme surrounding digit V, AER [1]; melanocyte cell lines [2] [1] [2].
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FF involved in limb morphogenesis [1];
FF may be involved in zone of polarizing (ZPA) induction [1];
FF repressor of TRP-1 (tyrosinease-related protein 1) expression [2];
FF USF-1 T00877 and Mitf T01554 can activate expression of TBX2 in melanocytes [3];
FF complementary expression pattern of TBX2 and Tbx3 T04359 in the limbs: TBX2 is expressed in the mesenchyme immediately underlying the posterior half of the apical ectodermal ridge (AER) whereas Tbx3 T04359 is expressed throughout the distal AER [1];
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IN T01423 pRb; mouse, Mus musculus.
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MX M08900 V$TBX2RELATED_Q6.
MX M05388 V$TBX2_04.
MX M03889 V$TBX2_Q2.
MX M08831 V$TBX2_Q5.
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BS R15796.
BS R30662.
BS R24615.
BS R73849.
BS R69896.
BS R69898.
BS R69899.
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DR TRANSPATH: MO000028216.
DR UniProtKB: Q60707;
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RN [1]; RE0015803.
RX PUBMED: 8798150.
RA Gibson-Brown J. J., Agulnik S. I., Chapman D. L., Alexiou M., Garvey N., Silver L. M., Papaioannou V. E.
RT Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
RL Mech. Dev. 56:93-101 (1996).
RN [2]; RE0016860.
RX PUBMED: 9710594.
RA Carreira S., Dexter T. J., Yavuzer U., Easty D. J., Goding C. R.
RT Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
RL Mol. Cell. Biol. 18:5099-5108 (1998).
RN [3]; RE0016864.
RX PUBMED: 10770922.
RA Carreira S., Liu B., Goding C. R.
RT The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
RL J. Biol. Chem. 275:21920-21927 (2000).
RN [4]; RE0070917.
RX PUBMED: 20534814.
RA Vance K. W., Shaw H. M., Rodriguez M., Ott S., Goding C. R.
RT The retinoblastoma protein modulates Tbx2 functional specificity.
RL Mol. Biol. Cell 21:2770-2779 (2010).
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