AC T04359
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ID T04359
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DT 26.02.2001 (created); rio.
DT 12.12.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA Tbx3
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SY T-box protein 3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006791 Tbx3.
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CL C0044; T-box; 6.5.4.0.2.
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SF complementary expression pattern of Tbx3 and Tbx2 T04358 in the limbs: Tbx3 is expressed throughout the distal apical ectodermal ridge (AER) whereas Tbx2 T04358 is expressed in the mesenchyme immediately underlying the posterior half of the AER [1];
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CP (E9.5:) posterior forelimb bud margin, (E10.5-11.5:) fore-/hindlimb bud mesenchyme, apical ectodermal ridge (AER), (E12.5-13.5:) mesenchyme surrounding digit I and V, AER [1]; NIH mouse fibroblasts [2].
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FF involved in limb morphogenesis [1];
FF may be involved in zone of polarizing (ZPA) induction [1];
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MX M08900 V$TBX2RELATED_Q6.
MX M05348 V$TBX3_02.
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BS R65250.
BS R24607.
BS R60160.
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DR TRANSPATH: MO000028217.
DR UniProtKB: P70324;
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RN [1]; RE0015803.
RX PUBMED: 8798150.
RA Gibson-Brown J. J., Agulnik S. I., Chapman D. L., Alexiou M., Garvey N., Silver L. M., Papaioannou V. E.
RT Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
RL Mech. Dev. 56:93-101 (1996).
RN [2]; RE0053229.
RX PUBMED: 15289316.
RA Fan W., Huang X., Chen C., Gray J., Huang T.
RT TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines.
RL Cancer Res. 64:5132-5139 (2004).
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