TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01554 XX ID T01554 XX DT 13.09.1995 (created); ewi. DT 12.02.2014 (updated); pro. CO Copyright (C), QIAGEN. XX FA MITF XX SY Mi; Microphthalmia; microphthalmia-associated transcription factor. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002682 Mitf. XX CL C0012; bHLH-ZIP; XX SF heterodimers with TFE3-related proteins, but not with E47, c-Myc, Max, USF [1]; SF many naturally occurring mutants [1]; XX CP melanocyte cell lines [4]. XX FF transcriptional activator (together with USF-1 T00877) of the T-box transcription factor Tbx2 T04358 in melanocytes [4]; XX IN T16150 BRG1; mouse, Mus musculus. IN T01553 MITF; human, Homo sapiens. IN T02083 Otx2; mouse, Mus musculus. IN T00702 PU.1; mouse, Mus musculus. IN T01552 tcfec; rat, Rattus norvegicus. IN T00811 TFEA; human, Homo sapiens. IN T00812 tfeb-isoform1; human, Homo sapiens. IN T18332 TLS; mouse, Mus musculus. XX MX M01034 V$EBOX_Q6_01. MX M07996 V$MITF_01. MX M07050 V$MITF_Q4. MX M02099 V$MITF_Q6. MX M01029 V$TFE_Q6. XX BS R24486. BS R24487. BS R15430. BS R15438. BS R15509. BS R24285. BS R24275. BS R24240. BS R24241. BS R24242. BS R29641. BS R24221. BS R23004. BS R22933. BS R15373. BS R15374. BS R24246. BS R34289. BS R60240. BS R15422. BS R29642. XX DR TRANSPATH: MO000025759. DR UniProtKB: Q08874; XX RN [1]; RE0003422. RX PUBMED: 7958932. RA Hemesath T. J., Steingrimsson E., McGill G., Hansen M. J., Vaught J., Hodgkinson C. A., Arnheiter H., Copeland N. G., Jenkins N. A., Fisher D. E. RT microphthalamia, a critical factor in melanocyte development, defines a discrete transcription factor family RL Genes Dev. 8:2770-2780 (1994). RN [2]; RE0003423. RX PUBMED: 8407885. RA Hughes M. J., Lingrel J. B., Krakowsky J. M., Anderson K. P. RT A helix-loop-helix transcription factor-like gene is located at the mi locus RL J. Biol. Chem. 268:20687-20690 (1993). RN [3]; RE0003424. RX PUBMED: 8343963. RA Hodgkinson C. A., Moore K. J., Nakayama A., Steingrimsson E., Copeland N. G., Jenkins A. N., Arnheiter H. RT Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel bHLH-Zip protein RL Cell 74:395-404 (1993). RN [4]; RE0016864. RX PUBMED: 10770922. RA Carreira S., Liu B., Goding C. R. RT The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes RL J. Biol. Chem. 275:21920-21927 (2000). RN [5]; RE0024642. RX PUBMED: 9700169. RA Bertolotto C., Abbe P., Hemesath T. J., Bille K., Fisher D. E., Ortonne J. P., Ballotti R. RT Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes. RL J. Cell Biol. 142:827-835 (1998). RN [6]; RE0024922. RX PUBMED: 12663655. RA Martinez-Morales J. R., Dolez V., Rodrigo I., Zaccarini R., Leconte L., Bovolenta P., Saule S. RT OTX2 activates the molecular network underlying retina pigment epithelium differentiation. RL J. Biol. Chem. 278:21721-21731 (2003). RN [7]; RE0048174. RX PUBMED: 15304486. RA Matsumoto M., Kogawa M., Wada S., Takayanagi H., Tsujimoto M., Katayama S., Hisatake K., Nogi Y. RT Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. RL J. Biol. Chem. 279:45969-45979 (2004). RN [8]; RE0049462. RX PUBMED: 15507434. RA Miller A. J., Levy C., Davis I. J., Razin E., Fisher D. E. RT Sumoylation of MITF and its related family members TFE3 and TFEB. RL J. Biol. Chem. 280:146-155 (2005). RN [9]; RE0051632. RX PUBMED: 17371876. RA Beuret L., Flori E., Denoyelle C., Bille K., Busca R., Picardo M., Bertolotto C., Ballotti R. RT Up-regulation of MET expression by alpha-melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis. RL J. Biol. Chem. 282:14140-14147 (2007). RN [10]; RE0052011. RX PUBMED: 15572665. RA Sonnenblick A., Levy C., Razin E. RT Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes. RL Mol. Cell. Biol. 24:10584-10592 (2004). RN [11]; RE0066606. RX PUBMED: 12485437. RA Lei T. C., Virador V., Yasumoto K., Vieira W. D., Toyofuku K., Hearing V. J. RT Stimulation of melanoblast pigmentation by 8-methoxypsoralen:the involvement of microphthalmia-associated transcription factor, the protein kinase a signal pathway, and proteasome-mediated degradation. RL J. Invest. Dermatol 119:1341-1349 (2002). RN [12]; RE0066612. RX PUBMED: 18272592. RA Bharti K., Liu W., Csermely T., Bertuzzi S., Arnheiter H. RT Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. RL Development 135:1169-1178 (2008). RN [13]; RE0066852. RX PUBMED: 20177067. RA Hoshino T., Matsuda M., Yamashita Y., Takehara M., Fukuya M., Mineda K., Maji D., Ihn H., Adachi H., Sobue G., Funasaka Y., Mizushima T. RT Suppression of melanin production by expression of HSP70. RL J. Biol. Chem. 285:13254-13263 (2010). RN [14]; RE0067039. RX PUBMED: 19174519. RA Le Pape E., Passeron T., Giubellino A., Valencia J. C., Wolber R., Hearing V. J. RT Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. RL Proc. Natl. Acad. Sci. USA 106:1802-1807 (2009). XX //