TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00811 XX ID T00811 XX DT 20.10.1992 (created); ewi. DT 25.08.2014 (updated); spk. CO Copyright (C), QIAGEN. XX FA TFEA XX SY bHLHe33; TFE3; transcription factor binding to IGHM enhancer 3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004669 TFE3; HGNC: TFE3. XX CL C0012; bHLH-ZIP; XX SF incompatible leucine zipper structures and HLH-ZIP distances prevent TFEA dimerization with USF, ITF-1, or Id [2]; SF TFEA induces DNA bending towards the minor groove by approx. 74-82 deg [3]; XX FF strong activator [1]; FF different from NF-muE3 or USF [1]; FF directly interacts and synergistically activates transcription with E2F3, but not with other members of E2F family [4]; XX IN T01545 E2F-3a; human, Homo sapiens. IN T01553 MITF; human, Homo sapiens. IN T01554 MITF; mouse, Mus musculus. IN T34674 prohibitin-2; human, Homo sapiens. IN T17026 RNF96; human, Homo sapiens. IN T10719 RPA3; human, Homo sapiens. IN T01552 tcfec; rat, Rattus norvegicus. IN T00811 TFEA; human, Homo sapiens. IN T00812 tfeb-isoform1; human, Homo sapiens. IN T17416 tfeb; Mammalia. XX MX M01034 V$EBOX_Q6_01. MX M08978 V$TFEA_02. MX M03890 V$TFEA_Q6. MX M01029 V$TFE_Q6. XX BS R00992. BS R38071. BS R37889. BS R10078. BS R00853. BS R15851. BS R73995. BS R02252. XX DR TRANSPATH: MO000025187. DR TRANSCOMPEL: C00035. DR TRANSCOMPEL: C00170. DR TRANSCOMPEL: C00171. DR TRANSCOMPEL: C00198. DR TRANSCOMPEL: C00245. DR TRANSCOMPEL: C00427. DR UniProtKB: P19532; XX RN [1]; RE0000607. RX PUBMED: 2338243. RA Beckmann H., Su L.-K., Kadesch T. RT TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer E3 motif RL Genes Dev. 4:167-179 (1990). RN [2]; RE0000701. RX PUBMED: 2044953. RA Beckmann H., Kadesch T. RT The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity RL Genes Dev. 5:1057-1066 (1991). RN [3]; RE0003338. RX PUBMED: 1465398. RA Fisher D. E., Parent L. A., Sharp P. A. RT Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992). RN [4]; RE0025050. RX PUBMED: 12748276. RA Giangrande P. H., Hallstrom T. C., Tunyaplin C., Calame K., Nevins J. R. RT Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. RL Mol. Cell. Biol. 23:3707-3720 (2003). XX //