AC T00811
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ID T00811
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DT 20.10.1992 (created); ewi.
DT 25.08.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA TFEA
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SY bHLHe33; TFE3; transcription factor binding to IGHM enhancer 3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004669 TFE3; HGNC: TFE3.
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CL C0012; bHLH-ZIP; 1.2.6.1.1.
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SF incompatible leucine zipper structures and HLH-ZIP distances prevent TFEA dimerization with USF, ITF-1, or Id [2];
SF TFEA induces DNA bending towards the minor groove by approx. 74-82 deg [3];
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FF strong activator [1];
FF different from NF-muE3 or USF [1];
FF directly interacts and synergistically activates transcription with E2F3, but not with other members of E2F family [4];
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IN T01545 E2F-3a; human, Homo sapiens.
IN T01553 MITF; human, Homo sapiens.
IN T01554 MITF; mouse, Mus musculus.
IN T34674 prohibitin-2; human, Homo sapiens.
IN T17026 RNF96; human, Homo sapiens.
IN T10719 RPA3; human, Homo sapiens.
IN T01552 tcfec; rat, Rattus norvegicus.
IN T00811 TFEA; human, Homo sapiens.
IN T00812 tfeb-isoform1; human, Homo sapiens.
IN T17416 tfeb; Mammalia.
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MX M01034 V$EBOX_Q6_01.
MX M08978 V$TFEA_02.
MX M03890 V$TFEA_Q6.
MX M01029 V$TFE_Q6.
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BS R00992.
BS R38071.
BS R37889.
BS R10078.
BS R00853.
BS R15851.
BS R73995.
BS R02252.
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DR TRANSPATH: MO000025187.
DR TRANSCOMPEL: C00035.
DR TRANSCOMPEL: C00170.
DR TRANSCOMPEL: C00171.
DR TRANSCOMPEL: C00198.
DR TRANSCOMPEL: C00245.
DR TRANSCOMPEL: C00427.
DR UniProtKB: P19532;
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RN [1]; RE0000607.
RX PUBMED: 2338243.
RA Beckmann H., Su L.-K., Kadesch T.
RT TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer E3 motif
RL Genes Dev. 4:167-179 (1990).
RN [2]; RE0000701.
RX PUBMED: 2044953.
RA Beckmann H., Kadesch T.
RT The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity
RL Genes Dev. 5:1057-1066 (1991).
RN [3]; RE0003338.
RX PUBMED: 1465398.
RA Fisher D. E., Parent L. A., Sharp P. A.
RT Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove
RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992).
RN [4]; RE0025050.
RX PUBMED: 12748276.
RA Giangrande P. H., Hallstrom T. C., Tunyaplin C., Calame K., Nevins J. R.
RT Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.
RL Mol. Cell. Biol. 23:3707-3720 (2003).
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//