AC T01553
XX
ID T01553
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DT 13.09.1995 (created); ewi.
DT 05.02.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA MITF
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SY Mi; Microphthalmia; microphthalmia-associated transcription factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002681 MITF; HGNC: MITF.
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CL C0012; bHLH-ZIP; 1.2.6.1.4.
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SF the carboxyl terminus of MITF may contain an activation domain [2];
SF at least seven isoforms are known (MITF-A, -B, -C, -H, -D,-E and -M) [4] [6];
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FF activator [2];
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IN T19042 LEF-1-isoform3; human, Homo sapiens.
IN T01553 MITF; human, Homo sapiens.
IN T01554 MITF; mouse, Mus musculus.
IN T08624 Sox-9; human, Homo sapiens.
IN T01552 tcfec; rat, Rattus norvegicus.
IN T00811 TFEA; human, Homo sapiens.
IN T00812 tfeb-isoform1; human, Homo sapiens.
IN T17416 tfeb; Mammalia.
IN T08660 YY1; human, Homo sapiens.
XX
MX M01034 V$EBOX_Q6_01.
MX M07050 V$MITF_Q4.
MX M02099 V$MITF_Q6.
MX M01029 V$TFE_Q6.
XX
BS R15486.
BS R24491.
BS R15381.
BS R15386.
BS R15387.
BS R15442.
BS R23005.
BS R41506.
BS R36620.
BS R21435.
BS R29769.
BS R23808.
BS R36621.
BS R36622.
BS R15371.
BS R71722.
BS R71724.
BS R71725.
BS R15372.
BS R34642.
BS R34644.
BS R56772.
BS R56773.
BS R56776.
BS R15441.
BS R15430.
BS R15438.
BS R15440.
BS R71212.
BS R15417.
BS R24228.
BS R16108.
BS R63238.
BS R63240.
BS R60240.
XX
DR TRANSPATH: MO000025758.
DR UniProtKB: O75030;
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RN [1]; RE0003425.
RX PUBMED: 8069297.
RA Tachibana M., Perez-Jurado L. A., Nakayama A., Hodgkinson C. A., Li X., Schneider M., Miki T., Fex J., Francke U., Arnheiter H.
RT Cloning of MITF, the human homolog of the mouse microphthalmia gene, and assignment to human chromosome 3, region p14.1-p12.3
RL Hum. Mol. Genet. 3:553-557 (1994).
RN [2]; RE0024401.
RX PUBMED: 8995290.
RA Yasumoto K., Yokoyama K., Takahashi K., Tomita Y., Shibahara S.
RT Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes.
RL J. Biol. Chem. 272:503-509 (1997).
RN [3]; RE0024468.
RX PUBMED: 12819038.
RA Du J., Miller A. J., Widlund H. R., Horstmann M. A., Ramaswamy S., Fisher D. E.
RT MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma.
RL Am. J. Pathol. 163:333-343 (2003).
RN [4]; RE0024474.
RX PUBMED: 12048204.
RA Saito H., Yasumoto K., Takeda K., Takahashi K., Fukuzaki A., Orikasa S., Shibahara S.
RT Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1.
RL J. Biol. Chem. 277:28787-28794 (2002).
RN [5]; RE0024475.
RX PUBMED: 12032083.
RA Yasumoto K., Takeda K., Saito H., Watanabe K., Takahashi K., Shibahara S.
RT Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling.
RL EMBO J. 21:2703-2714 (2002).
RN [6]; RE0024619.
RX PUBMED: 10747853.
RA Takeda K., Yasumoto K., Takada R., Takada S., Watanabe K., Udono T., Saito H., Takahashi K., Shibahara S.
RT Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.
RL J. Biol. Chem. 275:14013-14016 (2000).
RN [7]; RE0024642.
RX PUBMED: 9700169.
RA Bertolotto C., Abbe P., Hemesath T. J., Bille K., Fisher D. E., Ortonne J. P., Ballotti R.
RT Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes.
RL J. Cell Biol. 142:827-835 (1998).
RN [8]; RE0044188.
RX PUBMED: 14744763.
RA Miller A. J., Du J., Rowan S., Hershey C. L., Widlund H. R., Fisher D. E.
RT Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma
RL Cancer Res. 64:509-16 (2004).
RN [9]; RE0051632.
RX PUBMED: 17371876.
RA Beuret L., Flori E., Denoyelle C., Bille K., Busca R., Picardo M., Bertolotto C., Ballotti R.
RT Up-regulation of MET expression by alpha-melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis.
RL J. Biol. Chem. 282:14140-14147 (2007).
RN [10]; RE0065050.
RX PUBMED: 19937254.
RA Mizutani Y., Hayashi N., Kawashima M., Imokawa G.
RT A single UVB exposure increases the expression of functional KIT in human melanocytes by up-regulating MITF expression through the phosphorylation of p38/CREB.
RL Arch. Dermatol. Res. 302:283-294 (2009).
RN [11]; RE0065694.
RX PUBMED: 16246839.
RA Molina D. M., Grewal S., Bardwell L.
RT Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation.
RL J. Biol. Chem. 280:42051-42060 (2005).
RN [12]; RE0065709.
RX PUBMED: 18039926.
RA Sato-Jin K., Nishimura E. K., Akasaka E., Huber W., Nakano H., Miller A., Du J., Wu M., Hanada K., Sawamura D., Fisher D. E., Imokawa G.
RT Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders.
RL FASEB J. 22:1155-1168 (2008).
RN [13]; RE0066473.
RX PUBMED: 18650849.
RA Cook A. L., Chen W., Thurber A. E., Smit D. J., Smith A. G., Bladen T. G., Brown D. L., Duffy D. L., Pastorino L., Bianchi-Scarra G., Leonard J. H., Stow J. L., Sturm R. A.
RT Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci.
RL J. Invest. Dermatol 129:392-405 (2009).
RN [14]; RE0066589.
RX PUBMED: 18974267.
RA Spencer J. D., Schallreuter K. U.
RT Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating hormone/melanocortin-4 receptor signaling.
RL Endocrinology 150:1250-1258 (2009).
RN [15]; RE0066656.
RX PUBMED: 15899821.
RA Kadekaro A. L., Kavanagh R., Kanto H., Terzieva S., Hauser J., Kobayashi N., Schwemberger S., Cornelius J., Babcock G., Shertzer H. G., Scott G., Abdel-Malek Z. A.
RT alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes.
RL Cancer Res. 65:4292-4299 (2005).
RN [16]; RE0066671.
RX PUBMED: 19026785.
RA Yang G., Li Y., Nishimura E. K., Xin H., Zhou A., Guo Y., Dong L., Denning M. F., Nickoloff B. J., Cui R.
RT Inhibition of PAX3 by TGF-beta modulates melanocyte viability.
RL Mol. Cell 32:554-563 (2008).
RN [17]; RE0067026.
RX PUBMED: 18478240.
RA Ahn J. H., Jin S. H., Kang H. Y.
RT LPS induces melanogenesis through p38 MAPK activation in human melanocytes.
RL Arch. Dermatol. Res. 300:325-329 (2008).
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