AC T01545
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ID T01545
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DT 07.08.1995 (created); ewi.
DT 03.09.2013 (updated); uat.
CO Copyright (C), QIAGEN.
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FA E2F-3a
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SY E2F transcription factor 3; E2F-3; E2F3; E2F3a; KIAA0075.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002036 E2F3; HGNC: E2F3.
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CL C0023; fork head.
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SZ 465 AA; 49.2 kDa (cDNA) (calc.).
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SQ MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQI
SQ LTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALG
SQ RGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYD
SQ TSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQ
SQ WMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVT
SQ YQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSP
SQ MKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEG
SQ PFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS
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SC Swiss-Prot#O00716-1
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FT 20 327 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 178 243 
PF02319; E2F/DP family winged-helix DNA-binding domai.
FT 295 357 
marked box domain, interaction with TFE3 [4].
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SF clear binding preference to Rb over p107;
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FF transcriptional activator, synergistically acting through multiple E2F sites;
FF expression in T-cells depends on cell cycle reentry and peaks at G1/S phase transition and during S phase, where E2F-3 is associated with pRb [2];
FF directly interacts and synergistically activates transcription with TFE3, in contrast to other members of E2F family [4];
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IN T16158 RING1B; human, Homo sapiens.
IN T00811 TFEA; human, Homo sapiens.
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MX M00940 V$E2F1_Q6_01.
MX M02089 V$E2F3_Q6.
MX M00050 V$E2F_02.
MX M00803 V$E2F_Q2.
MX M00918 V$E2F_Q3_01.
MX M00919 V$E2F_Q4_01.
MX M00939 V$E2F_Q4_02.
MX M08875 V$E2F_Q4_03.
MX M00920 V$E2F_Q6_01.
XX
BS R04555.
BS R09600.
BS R25908.
BS R09599.
BS R09542.
BS R09543.
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DR TRANSPATH: MO000004279.
DR TRANSCOMPEL: C00427.
DR EMBL: D38550;
DR EMBL: Y10479;
DR UniProtKB: O00716-1;
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RN [1]; RE0003316.
RX PUBMED: 8246996.
RA Lees J. A., Saito M., Vidal M., Valentine M., Look T., Harlow E., Dyson N., Helin K.
RT The retinoblastoma protein binds to a family of E2F transcription factors
RL Mol. Cell. Biol. 13:7813-7825 (1993).
RN [2]; RE0012605.
RX PUBMED: 8657117.
RA Moberg K., Starz M. A., Lees J. A.
RT E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
RL Mol. Cell. Biol. 16:1436-1449 (1996).
RN [3]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
RN [4]; RE0025050.
RX PUBMED: 12748276.
RA Giangrande P. H., Hallstrom T. C., Tunyaplin C., Calame K., Nevins J. R.
RT Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.
RL Mol. Cell. Biol. 23:3707-3720 (2003).
RN [5]; RE0031299.
RX PUBMED: 12411495.
RA Schlisio S., Halperin T., Vidal M., Nevins J. R.
RT Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.
RL EMBO J. 21:5775-86 (2002).
RN [6]; RE0048944.
RX PUBMED: 16481464.
RA Hallstrom T. C., Nevins J. R.
RT Jab1 is a specificity factor for E2F1-induced apoptosis.
RL Genes Dev. 20:613-623 (2006).
RN [7]; RE0070084.
RX PUBMED: 19917728.
RA Martinez L. A., Goluszko E., Chen H. Z., Leone G., Post S., Lozano G., Chen Z., Chauchereau A.
RT E2F3 is a mediator of DNA damage-induced apoptosis.
RL Mol. Cell. Biol. 30:524-536 (2010).
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