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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02083 XX ID T02083 XX DT 29.01.1997 (created); ewi. DT 25.05.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA Otx2 XX SY orthodenticle related homeobox protein 2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004500 Otx2. XX HO Otd (Drosophila) T02078. XX CL C0006; homeo; 3.1.3.17.2. XX CP rostral brain: dorsal and most ventral regions of telencephalon, diencephalon, mesencephalon (day 10) [1]; 3,3 kb transcript from 7,5 dpc to 18,5 dpc mouse embryos, most abundant from 10,5 to 13,5 dpc; expression in the mesencephalon and diencephalon [4] [4] [1]. EX central nervous system,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6]. EX dorsal ridge of the headfold,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. EX future diencephalon,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6]. EX future mesencephalon,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. EX future prosencephalon,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. EX headfold,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. EX optic eminence,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. EX optic stalk,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6]. EX optic vesicle,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. EX optic vesicle,,,Theiler Stage 13; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [6]. EX optic vesicle,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6]. EX ventral edge of the headfold,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6]. EX ventral edge of the headfold,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5]. XX FF weak transcriptional activator [3]; XX IN T05686 Grg4; mouse, Mus musculus. IN T01554 MITF; mouse, Mus musculus. XX MX M08892 V$CRX_Q6. MX M01387 V$OTX2_01. MX M01719 V$OTX2_Q3. MX M04623 V$OTX2_Q3_01. MX M01117 V$OTX_Q1. XX BS R33369. BS R33370. BS R21679. BS R73163. BS R67189. BS R73346. BS R33360. BS R16176. BS R33342. XX DR TRANSPATH: MO000026149. DR UniProtKB: P80206; XX RN [1]; RE0005031. RX PUBMED: 1353865. RA Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Rambaldi M., Boncinelli E. RT Nested expression domains of four homeobox genes in developing rostral brain RL Nature 358:687-690 (1992). RN [2]; RE0005172. RX PUBMED: 8101484. RA Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M. R., Nigro V., Boncinelli E. RT A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo RL EMBO J. 12:2735-2747 (1993). RN [3]; RE0015734. RX PUBMED: 9371841. RA Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P. RT A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons RL Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997). RN [4]; RE0024916. RX PUBMED: 12055180. RA Zhang Y., Miki T., Iwanaga T., Koseki Y., Okuno M., Sunaga Y., Ozaki N., Yano H., Koseki H., Seino S. RT Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. RL J. Biol. Chem. 277:28065-28069 (2002). RN [5]; RE0015599. RX PUBMED: 9022063. RA Sheng H. Z., Bertuzzi S., Chiang C., Shawlot W., Taira M., Dawid I., Westphal H. RT Expression of murine Lhx5 suggests a role in specifying the forebrain RL Dev. Dyn. 208:266-277 (1997). RN [6]; RE0014693. RX PUBMED: 9096350. RA Furukawa T., Kozak C. A., Cepko C. L. RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997). XX //