AC T02083
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ID T02083
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DT 29.01.1997 (created); ewi.
DT 25.05.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA Otx2
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SY orthodenticle related homeobox protein 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004500 Otx2.
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HO Otd (Drosophila) T02078.
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CL C0006; homeo; 3.1.3.17.2.
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CP rostral brain: dorsal and most ventral regions of telencephalon, diencephalon, mesencephalon (day 10) [1]; 3,3 kb transcript from 7,5 dpc to 18,5 dpc mouse embryos, most abundant from 10,5 to 13,5 dpc; expression in the mesencephalon and diencephalon [4] [4] [1].
EX central nervous system,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX dorsal ridge of the headfold,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX future diencephalon,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX future mesencephalon,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX future prosencephalon,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX headfold,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX optic eminence,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX optic stalk,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX optic vesicle,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX optic vesicle,,,Theiler Stage 13; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX optic vesicle,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX ventral edge of the headfold,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX ventral edge of the headfold,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
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FF weak transcriptional activator [3];
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IN T05686 Grg4; mouse, Mus musculus.
IN T01554 MITF; mouse, Mus musculus.
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MX M08892 V$CRX_Q6.
MX M01387 V$OTX2_01.
MX M01719 V$OTX2_Q3.
MX M04623 V$OTX2_Q3_01.
MX M01117 V$OTX_Q1.
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BS R33369.
BS R33370.
BS R21679.
BS R73163.
BS R67189.
BS R73346.
BS R33360.
BS R16176.
BS R33342.
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DR TRANSPATH: MO000026149.
DR UniProtKB: P80206;
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RN [1]; RE0005031.
RX PUBMED: 1353865.
RA Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Rambaldi M., Boncinelli E.
RT Nested expression domains of four homeobox genes in developing rostral brain
RL Nature 358:687-690 (1992).
RN [2]; RE0005172.
RX PUBMED: 8101484.
RA Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M. R., Nigro V., Boncinelli E.
RT A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
RL EMBO J. 12:2735-2747 (1993).
RN [3]; RE0015734.
RX PUBMED: 9371841.
RA Smidt M. P., van Schaick H. S., Lanctot C., Tremblay J. J., Cox J. J., van der Kleij A. A., Wolterink G., Drouin J., Burbach J. P.
RT A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
RL Proc. Natl. Acad. Sci. USA 94:13305-13310 (1997).
RN [4]; RE0024916.
RX PUBMED: 12055180.
RA Zhang Y., Miki T., Iwanaga T., Koseki Y., Okuno M., Sunaga Y., Ozaki N., Yano H., Koseki H., Seino S.
RT Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family.
RL J. Biol. Chem. 277:28065-28069 (2002).
RN [5]; RE0015599.
RX PUBMED: 9022063.
RA Sheng H. Z., Bertuzzi S., Chiang C., Shawlot W., Taira M., Dawid I., Westphal H.
RT Expression of murine Lhx5 suggests a role in specifying the forebrain
RL Dev. Dyn. 208:266-277 (1997).
RN [6]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
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