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AC T02970
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ID T02970
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DT 18.02.2000 (created); rio.
DT 17.05.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA CHX10
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SY C. elegans ceh-10 homeo domain containing homolog; C. elegans ceh-10 homeo domain-containing homolog; Chx10; Hox-10; HOX10; OR; RET1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005938 Vsx2.
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HO Ceh-10 (C. elegans).
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CL C0006; homeo; 3.1.3.28.2.
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SF contains CVC domain which is a conserved region in CHX10/Vsx-1 T04139 T02970 T04143 T04144 and ceh-10 T02980 [4];
SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [3];
SF interaction with pRB-family proteins (pRB, p107, p130) mediated by helix I and helix II of the homeo domain [1];
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CP (embryo >8.5 days:) anterior optic vesicle, all neuroblasts of the optic cup, thalamus, hindbrain, ventral spinal cord [2]; (adult:) inner nuclear layer, (at low level in pons, medulla and spinal cord) [2] [2].
CN cerebellar plate [2].
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FF probably formation of the neuroretina and development and maintenance of the inner nuclear layer [2];
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IN T02971 p107; mouse, Mus musculus.
IN T01608 p130; human, Homo sapiens.
IN T02972 p130; mouse, Mus musculus.
IN T01423 pRb; mouse, Mus musculus.
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MX M00437 V$CHX10_01.
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BS R22181.
BS R22186.
BS R22185.
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DR TRANSPATH: MO000026923.
DR UniProtKB: Q61412;
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RN [1]; RE0014085.
RX PUBMED: 9464541.
RA Wiggan O., Taniguchi-Sidle A., Hamel P. A.
RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains
RL Oncogene 16:227-236 (1998).
RN [2]; RE0014097.
RX PUBMED: 7914735.
RA Liu I. S., Chen J. D., Ploder L., Vidgen D., van der Kooy D., Kalnins V. I., McInnes R. R.
RT Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer
RL Neuron 13:377-393 (1994).
RN [3]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [4]; RE0015515.
RX PUBMED: 7789259.
RA Svendsen P. C., McGhee J. D.
RT The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye
RL Development 121:1253-1262 (1995).
RN [5]; RE0066518.
RX PUBMED: 18417110.
RA Sigulinsky C. L., Green E. S., Clark A. M., Levine E. M.
RT Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.
RL Dev. Biol. 317:560-575 (2008).
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