TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02970 XX ID T02970 XX DT 18.02.2000 (created); rio. DT 17.05.2010 (updated); jig. CO Copyright (C), QIAGEN. XX FA CHX10 XX SY C. elegans ceh-10 homeo domain containing homolog; C. elegans ceh-10 homeo domain-containing homolog; Chx10; Hox-10; HOX10; OR; RET1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005938 Vsx2. XX HO Ceh-10 (C. elegans). XX CL C0006; homeo; XX SF contains CVC domain which is a conserved region in CHX10/Vsx-1 T04139 T02970 T04143 T04144 and ceh-10 T02980 [4]; SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [3]; SF interaction with pRB-family proteins (pRB, p107, p130) mediated by helix I and helix II of the homeo domain [1]; XX CP (embryo >8.5 days:) anterior optic vesicle, all neuroblasts of the optic cup, thalamus, hindbrain, ventral spinal cord [2]; (adult:) inner nuclear layer, (at low level in pons, medulla and spinal cord) [2] [2]. CN cerebellar plate [2]. XX FF probably formation of the neuroretina and development and maintenance of the inner nuclear layer [2]; XX IN T02971 p107; mouse, Mus musculus. IN T01608 p130; human, Homo sapiens. IN T02972 p130; mouse, Mus musculus. IN T01423 pRb; mouse, Mus musculus. XX MX M00437 V$CHX10_01. XX BS R22181. BS R22186. BS R22185. XX DR TRANSPATH: MO000026923. DR UniProtKB: Q61412; XX RN [1]; RE0014085. RX PUBMED: 9464541. RA Wiggan O., Taniguchi-Sidle A., Hamel P. A. RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains RL Oncogene 16:227-236 (1998). RN [2]; RE0014097. RX PUBMED: 7914735. RA Liu I. S., Chen J. D., Ploder L., Vidgen D., van der Kooy D., Kalnins V. I., McInnes R. R. RT Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer RL Neuron 13:377-393 (1994). RN [3]; RE0014693. RX PUBMED: 9096350. RA Furukawa T., Kozak C. A., Cepko C. L. RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997). RN [4]; RE0015515. RX PUBMED: 7789259. RA Svendsen P. C., McGhee J. D. RT The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye RL Development 121:1253-1262 (1995). RN [5]; RE0066518. RX PUBMED: 18417110. RA Sigulinsky C. L., Green E. S., Clark A. M., Levine E. M. RT Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. RL Dev. Biol. 317:560-575 (2008). XX //