AC T04139
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ID T04139
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DT 29.12.2000 (created); rio.
DT 22.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA CHX10
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SY ceh-10 homeodomain containing homolog.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013844 VSX2; HGNC: Vsx2.
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CL C0006; homeo; 3.1.3.28.2.
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SF contains CVC domain which is a conserved region in CHX10/Vsx-1 T04139 T02970 T04143 T04144 and ceh-10 T02980 [3];
SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [1];
SF 97% identical to murine CHX10 T02970 [2];
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CP (fetus 8-10 weeks:) retinal neuroblasts, (fetus 13 weeks:) inner nuclear layer, (adult:) inner nuclear layer [2].
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FF involved in microphthalmia [2];
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MX M00437 V$CHX10_01.
MX M04451 V$VSX2_01.
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DR TRANSPATH: MO000028041.
DR PATHODB: MT010681.
DR PATHODB: MT010682.
DR UniProtKB: P58304;
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RN [1]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [2]; RE0015510.
RX PUBMED: 10932181.
RA Ferda Percin E., Ploder L. A., Yu J. J., Arici K., Horsford D. J., Rutherford A., Bapat B., Cox D. W., Duncan A. M., Kalnins V. I., Kocak-Altintas A., Sowden J. C., Traboulsi E., Sarfarazi M., McInnes R. R.
RT Human microphthalmia associated with mutations in the retinal homeobox gene CHX10
RL Nat. Genet. 25:397-401 (2000).
RN [3]; RE0015515.
RX PUBMED: 7789259.
RA Svendsen P. C., McGhee J. D.
RT The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye
RL Development 121:1253-1262 (1995).
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