AC T02060
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ID T02060
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DT 28.01.1997 (created); ewi.
DT 30.12.2011 (updated); grs.
CO Copyright (C), QIAGEN.
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FA PMX1-isoform1
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SY MHox; Paired-like homeobox; Phox-1; Pmx; Pmx-1; PMX1-B.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014322 Prrx1.
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CL C0006; homeo; 3.1.3.21.1.2.
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SZ 245 AA; 27.3 kDa (cDNA) (calc.).
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SQ MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEA
SQ GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD
SQ AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV
SQ PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ
SQ VPTVN
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SC Swiss-Prot#P43271-1
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FT 92 152 
PS50071; HOMEOBOX_2.
FT 94 150 
PS50552; PAX.
FT 94 156 
SM00389; HOX_1.
FT 95 151 
PF00046; Homeobox domain.
FT 217 237 
PF03826; OAR domain.
FT 222 235 
PS50803; OAR.
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SF splice variant K-2b T02061 differs in its C-terminus [2];
SF homeo domain most similar to that of S8 (97% identity), suggested to constitute an own subclass of paired-type homeo domains [2];
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CP embryo: mesenchymal cells in craniofacial, pericardial, primitive dermal, prevertebral, and genital structures [2], visceral arch, limb bud [1]; adult: heart, skeletal muscle, uterus [1] [1] [2].
CN intestine, kidney, liver, pancreas, spleen, stomach [1].
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FF expression during embryogenesis is restricted to mesodermal cell types, highest levels in limb buds and visceral arches [1];
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MX M01348 V$K2B_01.
MX M03560 V$PMX1_Q6.
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DR TRANSPATH: MO000026129.
DR EMBL: X59725;
DR UniProtKB: P63013-1;
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RN [1]; RE0005123.
RX PUBMED: 1360403.
RA Cserjesi P., Lilly B., Bryson L. J., Wang Y., Sassoon D. A., Olson E. N.
RT MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer
RL Development 115:1087-1101 (1992).
RN [2]; RE0005125.
RX PUBMED: 1383943.
RA Kern M. J., Witte D. P., Valerius M. T., Aronow B. J., Potter S. S.
RT A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy
RL Nucleic Acids Res. 20:5189-5195 (1992).
RN [3]; RE0067849.
RX PUBMED: 12741393.
RA McKean D. M., Sisbarro L., Ilic D., Kaplan-Alburquerque N., Nemenoff R., Weiser-Evans M., Kern M. J., Jones P. L.
RT FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration.
RL J. Cell Biol. 161:393-402 (2003).
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