AC T06377
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ID T06377
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DT 15.12.2004 (created); cch.
DT 23.09.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA PML
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SY MYL; PML; probable transcription factor PML; promyelocytic leukemia; RING finger protein 71; RNF71; TRIM19; Tripartite motif-containing protein 19.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013657 PML; HGNC: PML.
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SF several splicing variants are known, e.g. PML-3 T05113;
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IN T00133 c-Jun; human, Homo sapiens.
IN T00143 c-Myc; mouse, Mus musculus.
IN T09007 c-Myc; mouse, Mus musculus.
IN T14435 c-Myc; Mammalia.
IN T06538 c-Ski; human, Homo sapiens.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T02944 Daxx; human, Homo sapiens.
IN T01546 E2F-4; human, Homo sapiens.
IN T00308 GATA-2; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T02092 Hex; human, Homo sapiens.
IN T23090 Hex; Mammalia.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T01608 p130; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T04931 p73alpha; human, Homo sapiens.
IN T14622 sin3a; human, Homo sapiens.
IN T24830 Smad2; Mammalia.
IN T10378 Smad3; human, Homo sapiens.
IN T04351 TBX2; human, Homo sapiens.
IN T04076 TGIF; human, Homo sapiens.
IN T20157 uhrf1; human, Homo sapiens.
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DR TRANSPATH: MO000045014.
DR UniProtKB: P29590;
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RN [1]; RE0028247.
RX PUBMED: 11430826.
RA Khan M. M., Nomura T., Kim H., Kaul S. C., Wadhwa R., Shinagawa T., Ichikawa-Iwata E., Zhong S., Pandolfi P. P., Ishii S.
RT Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
RL Mol. Cell 7:1233-43 (2001).
RN [2]; RE0047360.
RX PUBMED: 10938104.
RA Tsuzuki S., Towatari M., Saito H., Enver T.
RT Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.
RL Mol. Cell. Biol. 20:6276-6286 (2000).
RN [3]; RE0047365.
RX PUBMED: 9794812.
RA Carlile G. W., Tatton W. G., Borden K. L.
RT Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase.
RL Biochem. J. 335:691-696 (1998).
RN [4]; RE0047752.
RX PUBMED: 10610177.
RA Zhong S., Delva L., Rachez C., Cenciarelli C., Gandini D., Zhang H., Kalantry S., Freedman L. P., Pandolfi P. P.
RT A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
RL Nat. Genet. 23:287-295 (1999).
RN [5]; RE0047801.
RX PUBMED: 15626733.
RA Salomoni P., Bernardi R., Bergmann S., Changou A., Tuttle S., Pandolfi P. P.
RT The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.
RL Blood 105:3686-3690 (2005).
RN [6]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [7]; RE0047936.
RX PUBMED: 10669754.
RA Li H., Leo C., Zhu J., Wu X., O'Neil J., Park E. J., Chen J. D.
RT Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.
RL Mol. Cell. Biol. 20:1784-1796 (2000).
RN [8]; RE0048458.
RX PUBMED: 9412458.
RA Sternsdorf T., Jensen K., Will H.
RT Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
RL J. Cell Biol. 139:1621-1634 (1997).
RN [9]; RE0048481.
RX PUBMED: 15735755.
RA Cairo S., De Falco F., Pizzo M., Salomoni P., Pandolfi P. P., Meroni G.
RT PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
RL Oncogene 24:2195-2203 (2005).
RN [10]; RE0048810.
RX PUBMED: 17000644.
RA Vertegaal A. C., Andersen J. S., Ogg S. C., Hay R. T., Mann M., Lamond A. I.
RT Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.
RL Mol. Cell. Proteomics 5:2298-2310 (2006).
RN [11]; RE0048811.
RX PUBMED: 17027752.
RA Kunapuli P., Kasyapa C. S., Chin S. F., Cowell J. K., Caldas C.
RT ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML.
RL Exp. Cell Res. 312:3739-3751 (2006).
RN [12]; RE0048859.
RX PUBMED: 10684855.
RA Zhong S., Salomoni P., Ronchetti S., Guo A., Ruggero D., Pandolfi P. P.
RT Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
RL J. Exp. Med. 191:631-640 (2000).
RN [13]; RE0048880.
RX PUBMED: 12529400.
RA Ecsedy J. A., Michaelson J. S., Leder P.
RT Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
RL Mol. Cell. Biol. 23:950-960 (2003).
RN [14]; RE0052674.
RX PUBMED: 10597310.
RA Topcu Z., Mack D. L., Hromas R. A., Borden K. L.
RT The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.
RL Oncogene 18:7091-7100 (1999).
RN [15]; RE0052675.
RX PUBMED: 11259576.
RA Wu W. S., Vallian S., Seto E., Yang W. M., Edmondson D., Roth S., Chang K. S.
RT The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
RL Mol. Cell. Biol. 21:2259-2268 (2001).
RN [16]; RE0052804.
RX PUBMED: 15657436.
RA Topisirovic I., Kentsis A., Perez J. M., Guzman M. L., Jordan C. T., Borden K. L.
RT Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.
RL Mol. Cell. Biol. 25:1100-1112 (2005).
RN [17]; RE0065752.
RX PUBMED: 15459016.
RA Crowder C., Dahle O., Davis R. E., Gabrielsen O. S., Rudikoff S.
RT PML mediates IFN-alpha-induced apoptosis in myeloma by regulating TRAIL induction.
RL Blood 105:1280-1287 (2005).
RN [18]; RE0065863.
RX PUBMED: 16160161.
RA Boutell C., Canning M., Orr A., Everett R. D.
RT Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.
RL J. Virol. 79:12342-12354 (2005).
RN [19]; RE0066609.
RX PUBMED: 17062732.
RA Vlasakova J., Novakova Z., Rossmeislova L., Kahle M., Hozak P., Hodny Z.
RT Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein.
RL Blood 109:1373-1380 (2007).
RN [20]; RE0025265.
RX PUBMED: 15195100.
RA Bernardi R., Scaglioni P. P., Bergmann S., Horn H. F., Vousden K. H., Pandolfi P. P.
RT PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
RL Nat. Cell Biol. 6:665-672 (2004).
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