AC T00308
XX
ID T00308
XX
DT 28.01.1993 (created); ewi.
DT 13.08.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA GATA-2
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SY GATA-2; GATA-box binding factor 2; GATA2; NF-E1b (chick).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004497 GATA2; HGNC: GATA2.
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CL C0004; CC; 2.2.1.1.2.
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SF 2 zinc finger motifs;
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CP HepG2,Hep3B [9]; BeWO, JEG3 and primary trophoblast cells [10].
CN T-lymphocyte cell lines (MOLT4, Jurkat) [5].
EX blood,neutrophil granulocyte,,adult; very high; Northern blot; total RNA; [3].
EX prepuce of penis,fibroblast,,adult; detectable; Northern blot; total RNA; [1].
XX
FF down-regulated in HL-60 and EA.hy926 cells upon retinoic acid treatment [5];
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IN T08574 C/EBPalpha; rat, Rattus norvegicus.
IN T08664 C/EBPalpha; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T04110 HDAC3; human, Homo sapiens.
IN T05252 HDAC5; human, Homo sapiens.
IN T02092 Hex; human, Homo sapiens.
IN T08615 PLZFB; human, Homo sapiens.
IN T06377 PML; human, Homo sapiens.
IN T06379 PML; mouse, Mus musculus.
IN T02251 RBTN2; mouse, Mus musculus.
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MX M00076 V$GATA2_01.
MX M00348 V$GATA2_02.
MX M00349 V$GATA2_03.
MX M04864 V$GATA2_06.
MX M04949 V$GATA2_07.
MX M05725 V$GATA2_08.
MX M07213 V$GATA2_09.
MX M01877 V$GATA2_Q5.
MX M00203 V$GATA_C.
MX M00789 V$GATA_Q6.
XX
BS R02157.
BS R04902.
BS R39581.
BS R19648.
BS R19651.
BS R20887.
BS R26604.
BS R02797.
BS R08149.
BS R20913.
BS R21057.
BS R28627.
BS R28653.
BS R20993.
BS R41039.
BS R41045.
BS R38386.
BS R00590.
BS R20614.
BS R41053.
BS R40740.
BS R39832.
BS R39835.
BS R14541.
BS R36019.
BS R64441.
BS R64446.
BS R61872.
BS R61884.
BS R61890.
BS R61420.
BS R39880.
BS R33336.
BS R57793.
BS R37601.
BS R35578.
BS R20599.
BS R26950.
BS R26951.
BS R63805.
BS R55948.
BS R61567.
BS R64448.
BS R29016.
BS R32203.
BS R14558.
BS R40428.
BS R21076.
BS R62293.
BS R34944.
BS R69239.
BS R56070.
BS R20942.
BS R20583.
XX
DR TRANSPATH: MO000032472.
DR TRANSCOMPEL: C00026.
DR TRANSCOMPEL: C00088.
DR TRANSCOMPEL: C00147.
DR TRANSCOMPEL: C00362.
DR TRANSCOMPEL: C00381.
DR TRANSCOMPEL: C00603.
DR UniProtKB: P23769;
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RN [1]; RE0000948.
RX PUBMED: 1714909.
RA Lee M.-H., Temizer D. H., Clifford J. A., Quertermous T.
RT Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells
RL J. Biol. Chem. 266:16188-16192 (1991).
RN [2]; RE0002959.
RX PUBMED: 8321207.
RA Merika M., Orkin S. H.
RT DNA-binding specificity of GATA family transcription factors
RL Mol. Cell. Biol. 13:3999-4010 (1993).
RN [3]; RE0013448.
RX PUBMED: 8507862.
RA Zon L. I., Yamaguchi Y., Yee K., Albee E. A., Kimura A., Bennett J. C., Orkin S. H., Ackerman S. J.
RT Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.
RL Blood 81:3234-3241 (1993).
RN [4]; RE0013449.
RX PUBMED: 8643572.
RA Melotti P., Calabretta B.
RT The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis.
RL Proc. Natl. Acad. Sci. USA 93:5313-5318 (1996).
RN [5]; RE0013452.
RX PUBMED: 1370462.
RA Dorfman D. M., Wilson D. B., Bruns G. A. P., Orkin S. H.
RT Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.
RL J. Biol. Chem. 267:1279-1285 (1992).
RN [6]; RE0036169.
RX PUBMED: 15632071.
RA Tong Q., Tsai J., Tan G., Dalgin G., Hotamisligil G. S.
RT Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.
RL Mol. Cell. Biol. 25:706-715 (2005).
RN [7]; RE0047323.
RX PUBMED: 11964310.
RA Tsuzuki S., Enver T.
RT Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.
RL Blood 99:3404-3410 (2002).
RN [8]; RE0047360.
RX PUBMED: 10938104.
RA Tsuzuki S., Towatari M., Saito H., Enver T.
RT Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.
RL Mol. Cell. Biol. 20:6276-6286 (2000).
RN [9]; RE0049713.
RX PUBMED: 9028967.
RA Imagawa S., Yamamoto M., Miura Y.
RT Negative regulation of the erythropoietin gene expression by the GATA transcription factors.
RL Blood 89:1430-1439 (1997).
RN [10]; RE0049825.
RX PUBMED: 15888734.
RA Cheng Y. H., Handwerger S.
RT A placenta-specific enhancer of the human syncytin gene.
RL Biol. Reprod. 73:500-509 (2005).
RN [11]; RE0052827.
RX PUBMED: 15016828.
RA Minami T., Murakami T., Horiuchi K., Miura M., Noguchi T., Miyazaki J., Hamakubo T., Aird W. C., Kodama T.
RT Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.
RL J. Biol. Chem. 279:20626-20635 (2004).
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