AC T02092
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ID T02092
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DT 29.01.1997 (created); ewi.
DT 05.03.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Hex
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SY hematopoietically expressed homeobox; HEX; HHEX; HMPH; HOX11L-PEN; Prh; PRHX.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006200 HHEX; HGNC: HHEX.
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CL C0006; homeo; 3.1.2.8.1.
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CP hematopoietic cells, very low levels in adult liver and pancreas [1].
CN brain, heart, kidney, lung, muscle, placenta [1].
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IN T00308 GATA-2; human, Homo sapiens.
IN T06377 PML; human, Homo sapiens.
IN T11097 Sox-13; human, Homo sapiens.
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BS R21614.
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DR TRANSPATH: MO000026157.
DR UniProtKB: Q03014;
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RN [1]; RE0005187.
RX PUBMED: 8103988.
RA Hromas R. A., Collins S. J., Radich J.
RT PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells
RL Biochim. Biophys. Acta 195:976-983 (1993).
RN [2]; RE0035877.
RX PUBMED: 12554669.
RA Topisirovic I., Culjkovic B., Cohen N., Perez J. M., Skrabanek L., Borden K. L.
RT The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.
RL EMBO J. 22:689-703 (2003).
RN [3]; RE0052674.
RX PUBMED: 10597310.
RA Topcu Z., Mack D. L., Hromas R. A., Borden K. L.
RT The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.
RL Oncogene 18:7091-7100 (1999).
RN [4]; RE0052773.
RX PUBMED: 12826010.
RA Bess K. L., Swingler T. E., Rivett A. J., Gaston K., Jayaraman P. S.
RT The transcriptional repressor protein PRH interacts with the proteasome.
RL Biochem. J. 374:667-675 (2003).
RN [5]; RE0052804.
RX PUBMED: 15657436.
RA Topisirovic I., Kentsis A., Perez J. M., Guzman M. L., Jordan C. T., Borden K. L.
RT Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.
RL Mol. Cell. Biol. 25:1100-1112 (2005).
RN [6]; RE0052827.
RX PUBMED: 15016828.
RA Minami T., Murakami T., Horiuchi K., Miura M., Noguchi T., Miyazaki J., Hamakubo T., Aird W. C., Kodama T.
RT Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.
RL J. Biol. Chem. 279:20626-20635 (2004).
RN [7]; RE0066256.
RX PUBMED: 20028982.
RA Marfil V., Moya M., Pierreux C. E., Castell J. V., Lemaigre F. P., Real F. X., Bort R.
RT Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
RL J. Biol. Chem. 285:5726-5737 (2010).
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