AC T11097
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ID T11097
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DT 15.11.2007 (created); bch.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Sox-13
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SY ICA12; Islet cell antigen 12; Sox-13; SOX13; SRY (sex determining region Y)-box 13; Type 1 diabetes autoantigen ICA12.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004535 SOX13; HGNC: SOX13.
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CL C0015; HMG.
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SZ 890 AA; 99.0 kDa (calc.).
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SQ MVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSP
SQ EGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLSSDWKERFLGRNSMEAKDV
SQ KGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAMLFEKQQQQLELARQQQEQI
SQ AKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLPVTPDSQLALPIQPIPCKP
SQ VEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPKAPELPNTSSSPSLKMSSC
SQ LPRPPSHGGPTRDLAVQPPEPCLWASLVKGTLSPKPSRMLGSCCTATVGPWMAPPNTPFR
SQ KDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRNSSHIKRPMNAFMVWAKD
SQ ERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRP
SQ KRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMSSSDVLYPRAAGMPLAQP
SQ LVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYRYSEDEDSEGEEKSDGSW
SQ WCSQTDPRLGGPGPFSSGEDLVPTRWAQPANLRLCWYLDLFVPQKMGKAVHLADTFMRGE
SQ APSLPEERVGLGGQELQYGHGLSRLSTSAFRAYGQGTLYDSPLLQVSIHLGYGIYRPVSL
SQ GSHALFPFLSWLDQPLWDQHPSHTPPDCSSITRIALYFVQKGLAVPCCFHLCQAYCALAA
SQ VCVRVHVCVFHLFIHCTRYLLSAHYVPGTVAEFLWVCLSMPLLLLWGPLSVLLFVPKLLP
SQ LCQSGCLRFCVSLCAFLSLSVLVSLQGPLFLSYLGVCPLPPVPSGFSGSM
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SC translated from EMBL #AF083105
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FT 406 476 
SM00398; hmgende2.
FT 407 475 
PF00505; HMG (high mobility group) box.
FT 407 475 
PS50118; HMG_BOX_2.
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IN T02092 Hex; human, Homo sapiens.
IN T09354 Hex; mouse, Mus musculus.
IN T16692 TCF-1; Mammalia.
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MX M08899 V$SOX_Q4.
MX M01014 V$SOX_Q6.
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BS R15226.
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DR TRANSPATH: MO000117463.
DR EMBL: AF083105; AF083105.
DR EMBL: AF116571; AF116571.
DR UniProtKB: Q9UN79; SX13_HUMAN.
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RN [1]; RE0024425.
RX PUBMED: 10871192.
RA Kasimiotis H., Myers M. A., Argentaro A., Mertin S., Fida S., Ferraro T., Olsson J., Rowley M. J., Harley V. R.
RT Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets.
RL Diabetes 49:555-561 (2000).
RN [2]; RE0066256.
RX PUBMED: 20028982.
RA Marfil V., Moya M., Pierreux C. E., Castell J. V., Lemaigre F. P., Real F. X., Bort R.
RT Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
RL J. Biol. Chem. 285:5726-5737 (2010).
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//