AC T09354
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ID T09354
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DT 03.10.2006 (created); jay.
DT 27.04.2010 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Hex
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SY hematopoietically expressed homeobox; HEX; HHEX; Prh; PRHX.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006201 Hhex.
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CL C0006; homeo.
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SZ 271 AA; 30.0 kDa (cDNA) (calc.).
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SQ MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPSPNSSFT
SQ SLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPSGFGGPLYPFPRTVNDYTHALLRHDP
SQ LGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSER
SQ QVKTWFQNRRAKWRRLKQENPQSNKKDALDSLDTSCEQGQDLPSEQNKGASLDRSQCSPS
SQ PASQEDPDSEISEDSDQEVDIEGDKGYFNAG
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SC translated from EMBL #Z21524
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FT 136 196 
PS50071; HOMEOBOX_2.
FT 137 200 
SM00389; HOX_1.
FT 139 195 
PF00046; Homeobox domain.
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FF Hex stimulates gene expression of ntcp via the HRE in HepG2 cells but not in COS cells [4];
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IN T09446 c-Jun; Mammalia.
IN T10510 JunB; Mammalia.
IN T09447 JunD; Mammalia.
IN T08441 Sox-10; rat, Rattus norvegicus.
IN T02420 Sox-13; mouse, Mus musculus.
IN T11097 Sox-13; human, Homo sapiens.
IN T14088 Sox-8; mouse, Mus musculus.
IN T00765 SRF-L; mouse, Mus musculus.
IN T05114 SRF; mouse, Mus musculus.
IN T09097 SRY; human, Homo sapiens.
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BS R21614.
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DR TRANSPATH: MO000088097.
DR EMBL: Z21524;
DR UniProtKB: P43120;
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RN [1]; RE0014567.
RX PUBMED: 9389666.
RA Thomas P. Q., Brown A., Beddington R. S.
RT Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
RL Development 125:85-94 (1998).
RN [2]; RE0047860.
RX PUBMED: 15242862.
RA Oyama Y., Kawai-Kowase K., Sekiguchi K., Sato M., Sato H., Yamazaki M., Ohyama Y., Aihara Y., Iso T., Okamaoto E., Nagai R., Kurabayashi M.
RT Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts.
RL Arterioscler. Thromb. Vasc. Biol. 24:1602-1607 (2004).
RN [3]; RE0048308.
RX PUBMED: 16582099.
RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
RL Nucleic Acids Res. 34:1735-1744 (2006).
RN [4]; RE0050391.
RX PUBMED: 10915644.
RA Denson L. A., Karpen S. J., Bogue C. W., Jacobs H. C.
RT Divergent homeobox gene hex regulates promoter of the Na(+)-dependent bile acid cotransporter.
RL Am. J. Physiol. Gastrointest. Liver Physiol. 279:G347-55 (2000).
RN [5]; RE0052694.
RX PUBMED: 11551904.
RA Schaefer L. K., Wang S., Schaefer T. S.
RT Functional interaction of Jun and homeodomain proteins.
RL J. Biol. Chem. 276:43074-43082 (2001).
RN [6]; RE0066256.
RX PUBMED: 20028982.
RA Marfil V., Moya M., Pierreux C. E., Castell J. V., Lemaigre F. P., Real F. X., Bort R.
RT Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
RL J. Biol. Chem. 285:5726-5737 (2010).
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