AC T04110
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ID T04110
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DT 12.12.2000 (created); rio.
DT 29.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA HDAC3
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SY HD3; HDAC3; histone deacetylase 3; RPD3; RPD3-2; SMAP45.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003821 HDAC3; HGNC: HDAC3.
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SF 60% and 58% similarity to HDAC1 T04106 and HDAC2 T04109 [2];
SF interaction with YY1 T00915 [2];
SF forms a transcriptional corepressor complex with TGIF T04076 and SMAD T04095 T04096 [1];
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CP ubiquitously.
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [2].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [2].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [2].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [2].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; medium; Northern blot; mRNA (poly-A); [2].
EX brain,,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX liver,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX lung (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX mucosa of colon,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX muscles,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX ovary (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX pancreas,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX placenta,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX prostate gland,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX small intestine,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX spleen,,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX testis (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX thymus,,,adult; medium; Northern blot; mRNA (poly-A); [2].
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FF transcriptional repressor [2];
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IN T05453 BAF60A; human, Homo sapiens.
IN T34300 BCOR-isoform2; human, Homo sapiens.
IN T34301 BCOR-S; human, Homo sapiens.
IN T09998 c-Myc; human, Homo sapiens.
IN T10398 C/EBPdelta; Mammalia.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T01546 E2F-4; human, Homo sapiens.
IN T08291 GATA-1-isoform1; mouse, Mus musculus.
IN T00308 GATA-2; human, Homo sapiens.
IN T17631 HDAC1; mouse, Mus musculus.
IN T08522 HDAC4-isoform1; human, Homo sapiens.
IN T06042 HDAC4; human, Homo sapiens.
IN T05252 HDAC5; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T00490 MAZ-isoform1; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T25701 MTG8B; human, Homo sapiens.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T04687 NCOR1; human, Homo sapiens.
IN T01486 p107; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T19187 PML-4; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T25008 pRb; Mammalia.
IN T27214 RBBP1; human, Homo sapiens.
IN T10594 SHP; human, Homo sapiens.
IN T09272 SMRT-Alpha; mouse, Mus musculus.
IN T04689 SMRT; human, Homo sapiens.
IN T11420 Tbx3; human, Homo sapiens.
IN T00824 TFII-I; human, Homo sapiens.
IN T04076 TGIF; human, Homo sapiens.
IN T00915 YY1; human, Homo sapiens.
IN T19396 Zbtb5; human, Homo sapiens.
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BS R31240.
BS R31243.
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DR TRANSPATH: MO000023578.
DR UniProtKB: O15379;
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RN [1]; RE0015455.
RX PUBMED: 10601270.
RA Wotton D., Lo R. S., Swaby L. A., Massague J.
RT Multiple modes of repression by the Smad transcriptional corepressor TGIF
RL J. Biol. Chem. 274:37105-37110 (1999).
RN [2]; RE0015512.
RX PUBMED: 9346952.
RA Yang W. M., Yao Y. L., Sun J. M., Davie J. R., Seto E.
RT Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family
RL J. Biol. Chem. 272:28001-28007 (1997).
RN [3]; RE0025804.
RX PUBMED: 14668799.
RA Watamoto K., Towatari M., Ozawa Y., Miyata Y., Okamoto M., Abe A., Naoe T., Saito H.
RT Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation.
RL Oncogene 22:9176-84 (2003).
RN [4]; RE0026518.
RX PUBMED: 10809664.
RA Guenther M. G., Lane W. S., Fischle W., Verdin E., Lazar M. A., Shiekhattar R.
RT A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
RL Genes Dev. 14:1048-57 (2000).
RN [5]; RE0026599.
RX PUBMED: 10898795.
RA Huynh K. D., Fischle W., Verdin E., Bardwell V. J.
RT BCoR, a novel corepressor involved in BCL-6 repression.
RL Genes Dev. 14:1810-23 (2000).
RN [6]; RE0028350.
RX PUBMED: 11302704.
RA Taplick J., Kurtev V., Kroboth K., Posch M., Lechner T., Seiser C.
RT Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.
RL J. Mol. Biol. 308:27-38 (2001).
RN [7]; RE0028372.
RX PUBMED: 11486036.
RA Yao Y. L., Yang W. M., Seto E.
RT Regulation of transcription factor YY1 by acetylation and deacetylation.
RL Mol. Cell. Biol. 21:5979-91 (2001).
RN [8]; RE0029293.
RX PUBMED: 11804585.
RA Fischle W., Dequiedt F., Hendzel M. J., Guenther M. G., Lazar M. A., Voelter W., Verdin E.
RT Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
RL Mol. Cell 9:45-57 (2002).
RN [9]; RE0031419.
RX PUBMED: 12972430.
RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A.
RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
RL J. Biol. Chem. 278:46541-8 (2003).
RN [10]; RE0036641.
RX PUBMED: 12628926.
RA Yoon H. G., Chan D. W., Huang Z. Q., Li J., Fondell J. D., Qin J., Wong J.
RT Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
RL EMBO J. 22:1336-1346 (2003).
RN [11]; RE0038030.
RX PUBMED: 11509652.
RA Guenther M. G., Barak O., Lazar M. A.
RT The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
RL Mol. Cell. Biol. 21:6091-101 (2001).
RN [12]; RE0038035.
RX PUBMED: 12393887.
RA Wen Y. D., Cress W. D., Roy A. L., Seto E.
RT Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I
RL J. Biol. Chem. 278:1841-7 (2003).
RN [13]; RE0038054.
RX PUBMED: 11777905.
RA Johnson C. A., White D. A., Lavender J. S., O Neill L. P., Turner B. M.
RT Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70
RL J. Biol. Chem. 277:9590-7 (2002).
RN [14]; RE0038073.
RX PUBMED: 11533236.
RA Amann J. M., Nip J., Strom D. K., Lutterbach B., Harada H., Lenny N., Downing J. R., Meyers S., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
RL Mol. Cell. Biol. 21:6470-83 (2001).
RN [15]; RE0038083.
RX PUBMED: 11466315.
RA Fischle W., Dequiedt F., Fillion M., Hendzel M. J., Voelter W., Verdin E.
RT Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
RL J. Biol. Chem. 276:35826-35 (2001).
RN [16]; RE0047766.
RX PUBMED: 11788710.
RA Vaute O., Nicolas E., Vandel L., Trouche D.
RT Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.
RL Nucleic Acids Res. 30:475-481 (2002).
RN [17]; RE0047936.
RX PUBMED: 10669754.
RA Li H., Leo C., Zhu J., Wu X., O'Neil J., Park E. J., Chen J. D.
RT Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.
RL Mol. Cell. Biol. 20:1784-1796 (2000).
RN [18]; RE0048484.
RX PUBMED: 10860984.
RA Wen Y. D., Perissi V., Staszewski L. M., Yang W. M., Krones A., Glass C. K., Rosenfeld M. G., Seto E.
RT The histone deacetylase-3 complex contains nuclear receptor corepressors.
RL Proc. Natl. Acad. Sci. USA 97:7202-7207 (2000).
RN [19]; RE0048529.
RX PUBMED: 14527417.
RA Yoon H. G., Chan D. W., Reynolds A. B., Qin J., Wong J.
RT N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.
RL Mol. Cell 12:723-734 (2003).
RN [20]; RE0048630.
RX PUBMED: 15601853.
RA Yoon H. G., Choi Y., Cole P. A., Wong J.
RT Reading and function of a histone code involved in targeting corepressor complexes for repression.
RL Mol. Cell. Biol. 25:324-35 (2005).
RN [21]; RE0049111.
RX PUBMED: 16421255.
RA Tiefenbach J., Novac N., Ducasse M., Eck M., Melchior F., Heinzel T.
RT SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
RL Mol. Biol. Cell 17:1643-1651 (2006).
RN [22]; RE0049206.
RX PUBMED: 16478987.
RA Bhakat K. K., Mokkapati S. K., Boldogh I., Hazra T. K., Mitra S.
RT Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.
RL Mol. Cell. Biol. 26:1654-1665 (2006).
RN [23]; RE0049613.
RX PUBMED: 17101790.
RA Escaffit F., Vaute O., Chevillard-Briet M., Segui B., Takami Y., Nakayama T., Trouche D.
RT Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression.
RL Mol. Cell. Biol. 27:554-567 (2007).
RN [24]; RE0051082.
RX PUBMED: 17895379.
RA Sanyal S., Bavner A., Haroniti A., Nilsson L. M., Lundasen T., Rehnmark S., Witt M. R., Einarsson C., Talianidis I., Gustafsson J. A., Treuter E.
RT Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.
RL Proc. Natl. Acad. Sci. USA 104:15665-15670 (2007).
RN [25]; RE0052125.
RX PUBMED: 18097041.
RA Zhang Y., Tuzova M., Xiao Z. X., Cruikshank W. W., Center D. M.
RT Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP.
RL J. Immunol. 180:402-408 (2008).
RN [26]; RE0052206.
RX PUBMED: 12082111.
RA Tsai S. C., Seto E.
RT Regulation of histone deacetylase 2 by protein kinase CK2.
RL J. Biol. Chem. 277:31826-31833 (2002).
RN [27]; RE0052309.
RX PUBMED: 10490602.
RA Lai A., Lee J. M., Yang W. M., DeCaprio J. A., Kaelin WG J. r., Seto E., Branton P. E.
RT RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.
RL Mol. Cell. Biol. 19:6632-6641 (1999).
RN [28]; RE0052481.
RX PUBMED: 12590135.
RA Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A.
RT The histone deacetylase 9 gene encodes multiple protein isoforms.
RL J. Biol. Chem. 278:16059-16072 (2003).
RN [29]; RE0052675.
RX PUBMED: 11259576.
RA Wu W. S., Vallian S., Seto E., Yang W. M., Edmondson D., Roth S., Chang K. S.
RT The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
RL Mol. Cell. Biol. 21:2259-2268 (2001).
RN [30]; RE0053121.
RX PUBMED: 18245468.
RA Yarosh W., Barrientos T., Esmailpour T., Lin L., Carpenter P. M., Osann K., Anton-Culver H., Huang T.
RT TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.
RL Cancer Res. 68:693-699 (2008).
RN [31]; RE0064899.
RX PUBMED: 17925399.
RA Villagra A., Ulloa N., Zhang X., Yuan Z., Sotomayor E., Seto E.
RT Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.
RL J. Biol. Chem. 282:35457-35470 (2007).
RN [32]; RE0072504.
RX PUBMED: 21444723.
RA Pillai V. B., Sundaresan N. R., Samant S. A., Wolfgeher D., Trivedi C. M., Gupta M. P.
RT Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.
RL Mol. Cell. Biol. 31:2349-2363 (2011).
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