AC T25701
XX
ID T25701
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DT 18.04.2006 (created); rad.
DT 22.11.2006 (updated); sou.
CO Copyright (C), QIAGEN.
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FA MTG8B
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SY AML1T1; CBFA2T1; CDR; Cyclin D-related protein; eight twenty one protein; ETO; MGC2796; MTG8; MTG8b; Protein CBFA2T1; Protein ETO; Protein MTG8; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1T1; Zinc finger MYND domain-containing protein 2; ZMYND2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G018247 RUNX1T1; HGNC: RUNX1T1.
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SZ 604 AA; 67.6 kDa (cDNA) (calc.).
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SQ MISVKRNTWRALSLVIGDCRKKGNFEYCQDRTEKHSTMPDSPVDVKTQSRLTPPTMPPPP
SQ TTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGA
SQ RQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPF
SQ VIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENG
SQ KRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHY
SQ RLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHL
SQ LNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSSHSRQQSPVN
SQ PDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMIT
SQ TERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQ
SQ HKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIE
SQ TTPR
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SC translated from EMBL:D14821
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FT 217 385 
confer transcriptional repression [1].
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IN T04106 HDAC1; human, Homo sapiens.
IN T25625 hdac2; human, Homo sapiens.
IN T04110 HDAC3; human, Homo sapiens.
IN T28748 HDAC8; human, Homo sapiens.
IN T16997 MTG8; human, Homo sapiens.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T14622 sin3a; human, Homo sapiens.
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DR TRANSPATH: MO000080181.
DR EMBL: D14821; HSMTG8B.
DR UniProtKB: Q06455-1;
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RN [1]; RE0038073.
RX PUBMED: 11533236.
RA Amann J. M., Nip J., Strom D. K., Lutterbach B., Harada H., Lenny N., Downing J. R., Meyers S., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
RL Mol. Cell. Biol. 21:6470-83 (2001).
RN [2]; RE0048493.
RX PUBMED: 11150306.
RA Hildebrand D., Tiefenbach J., Heinzel T., Grez M., Maurer A. B.
RT Multiple regions of ETO cooperate in transcriptional repression.
RL J. Biol. Chem. 276:9889-9895 (2001).
RN [3]; RE0048494.
RX PUBMED: 9819404.
RA Lutterbach B., Westendorf J. J., Linggi B., Patten A., Moniwa M., Davie J. R., Huynh K. D., Bardwell V. J., Lavinsky R. M., Rosenfeld M. G., Glass C., Seto E., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors.
RL Mol. Cell. Biol. 18:7176-7184 (1998).
RN [4]; RE0048852.
RX PUBMED: 15377655.
RA Lausen J., Cho S., Liu S., Werner M. H.
RT The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.
RL J. Biol. Chem. 279:49281-49288 (2004).
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