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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T25701 XX ID T25701 XX DT 18.04.2006 (created); rad. DT 22.11.2006 (updated); sou. CO Copyright (C), QIAGEN. XX FA MTG8B XX SY AML1T1; CBFA2T1; CDR; Cyclin D-related protein; eight twenty one protein; ETO; MGC2796; MTG8; MTG8b; Protein CBFA2T1; Protein ETO; Protein MTG8; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1T1; Zinc finger MYND domain-containing protein 2; ZMYND2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G018247 RUNX1T1; HGNC: RUNX1T1. XX SZ 604 AA; 67.6 kDa (cDNA) (calc.). XX SQ MISVKRNTWRALSLVIGDCRKKGNFEYCQDRTEKHSTMPDSPVDVKTQSRLTPPTMPPPP SQ TTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGA SQ RQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPF SQ VIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENG SQ KRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHY SQ RLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHL SQ LNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSSHSRQQSPVN SQ PDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMIT SQ TERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQ SQ HKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIE SQ TTPR XX SC translated from EMBL:D14821 XX FT 217 385 confer transcriptional repression [1]. XX IN T04106 HDAC1; human, Homo sapiens. IN T25625 hdac2; human, Homo sapiens. IN T04110 HDAC3; human, Homo sapiens. IN T28748 HDAC8; human, Homo sapiens. IN T16997 MTG8; human, Homo sapiens. IN T08641 NCOR1-isoform1; mouse, Mus musculus. IN T14622 sin3a; human, Homo sapiens. XX DR TRANSPATH: MO000080181. DR EMBL: D14821; HSMTG8B. DR UniProtKB: Q06455-1; XX RN [1]; RE0038073. RX PUBMED: 11533236. RA Amann J. M., Nip J., Strom D. K., Lutterbach B., Harada H., Lenny N., Downing J. R., Meyers S., Hiebert S. W. RT ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain RL Mol. Cell. Biol. 21:6470-83 (2001). RN [2]; RE0048493. RX PUBMED: 11150306. RA Hildebrand D., Tiefenbach J., Heinzel T., Grez M., Maurer A. B. RT Multiple regions of ETO cooperate in transcriptional repression. RL J. Biol. Chem. 276:9889-9895 (2001). RN [3]; RE0048494. RX PUBMED: 9819404. RA Lutterbach B., Westendorf J. J., Linggi B., Patten A., Moniwa M., Davie J. R., Huynh K. D., Bardwell V. J., Lavinsky R. M., Rosenfeld M. G., Glass C., Seto E., Hiebert S. W. RT ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. RL Mol. Cell. Biol. 18:7176-7184 (1998). RN [4]; RE0048852. RX PUBMED: 15377655. RA Lausen J., Cho S., Liu S., Werner M. H. RT The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO. RL J. Biol. Chem. 279:49281-49288 (2004). XX //