AC T16997
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ID T16997
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DT 20.05.2005 (created); spi.
DT 16.10.2006 (updated); sou.
CO Copyright (C), QIAGEN.
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FA MTG8
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SY AML1T1; CBFA2T1; CDR; cyclin D related protein; eight twenty one protein; ETO; RUNX1T1; zinc finger MYND domain containing protein 2; ZMYND2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G018247 RUNX1T1; HGNC: RUNX1T1.
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CP expression in CD34+ and several leukemic cell lines, early myeloid cells, hematopoietic cell lines (HEL, EML) [4].
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FF co-repressor for PLZF;
FF ETO (=MTG8) potentiates transcriptional repression mediated by PLZF T02336 [4];
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IN T25625 hdac2; human, Homo sapiens.
IN T25701 MTG8B; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T14622 sin3a; human, Homo sapiens.
IN T34363 TRAP150; human, Homo sapiens.
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DR TRANSPATH: MO000054450.
DR UniProtKB: Q06455;
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RN [1]; RE0035187.
RX PUBMED: 10973986.
RA Wood J. D., Nucifora FC J. r., Duan K., Zhang C., Wang J., Kim Y., Schilling G., Sacchi N., Liu J. M., Ross C. A.
RT Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.
RL J. Cell Biol. 150:939-948 (2000).
RN [2]; RE0048493.
RX PUBMED: 11150306.
RA Hildebrand D., Tiefenbach J., Heinzel T., Grez M., Maurer A. B.
RT Multiple regions of ETO cooperate in transcriptional repression.
RL J. Biol. Chem. 276:9889-9895 (2001).
RN [3]; RE0048494.
RX PUBMED: 9819404.
RA Lutterbach B., Westendorf J. J., Linggi B., Patten A., Moniwa M., Davie J. R., Huynh K. D., Bardwell V. J., Lavinsky R. M., Rosenfeld M. G., Glass C., Seto E., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors.
RL Mol. Cell. Biol. 18:7176-7184 (1998).
RN [4]; RE0035558.
RX PUBMED: 10688654.
RA Melnick A. M., Westendorf J. J., Polinger A., Carlile G. W., Arai S., Ball H. J., Lutterbach B., Hiebert S. W., Licht J. D.
RT The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein.
RL Mol. Cell. Biol. 20:2075-2086 (2000).
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