AC T25625
XX
ID T25625
XX
DT 27.01.2006 (created); din.
DT 18.11.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA hdac2
XX
SY HD2; histone deacetylase 2; reduced potassium dependency 3; RPD3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003820 HDAC2; HGNC: HDAC2.
XX
FF Binds (particularly phosphorylated form) to PS2 G000373 promoter both in presence and absence of E2 [24];
XX
IN T05499 BAF47; human, Homo sapiens.
IN T21924 BCL-11A; human, Homo sapiens.
IN T02322 BCL-6; human, Homo sapiens.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T00929 Blimp-1; human, Homo sapiens.
IN T19002 BRAF35; human, Homo sapiens.
IN T08887 brca1-isoform1; human, Homo sapiens.
IN T00137 c-Myb; human, Homo sapiens.
IN T09170 CtBP1-isoform1; human, Homo sapiens.
IN T10784 CtBP1; Mammalia.
IN T27198 DNA (cytosine-5)-methyltransferase 3B; human, Homo sapiens.
IN T34272 EED; human, Homo sapiens.
IN T25772 ESET-isoform1; mouse, Mus musculus.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T08100 EWS; human, Homo sapiens.
IN T04888 EZH2; human, Homo sapiens.
IN T27302 GATAD2A; human, Homo sapiens.
IN T14242 GKLF-isoform1; human, Homo sapiens.
IN T14243 GKLF; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T08343 HDAC1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T01713 HOXA10-PL1; human, Homo sapiens.
IN T15475 Ikaros-1; Mammalia.
IN T15348 Ikaros; Mammalia.
IN T16406 MBD2; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T34374 Mi2-BETA; human, Homo sapiens.
IN T10759 MTA-1; human, Homo sapiens.
IN T33892 MTA-1; Mammalia.
IN T05115 MTA1L1; human, Homo sapiens.
IN T16997 MTG8; human, Homo sapiens.
IN T25701 MTG8B; human, Homo sapiens.
IN T01486 p107; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T27214 RBBP1; human, Homo sapiens.
IN T22425 RCOR1; human, Homo sapiens.
IN T02397 Sin3A-xbb2; mouse, Mus musculus.
IN T14622 sin3a; human, Homo sapiens.
IN T06312 SNA; human, Homo sapiens.
IN T15704 SNA; Mammalia.
IN T22463 SNF2H; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T02338 Sp3; human, Homo sapiens.
IN T18015 SUZ12; human, Homo sapiens.
IN T11420 Tbx3; human, Homo sapiens.
IN T00915 YY1; human, Homo sapiens.
XX
MX M04819 V$HDAC2_02.
MX M04839 V$HDAC2_03.
MX M04866 V$HDAC2_04.
MX M04870 V$HDAC2_05.
MX M04967 V$HDAC2_06.
XX
BS R56354.
BS R56347.
BS R56348.
XX
DR TRANSPATH: MO000058923.
DR UniProtKB: Q92769; HDA2_HUMAN.
XX
RN [1]; RE0026561.
RX PUBMED: 10766745.
RA Koipally J., Georgopoulos K.
RT Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
RL J. Biol. Chem. 275:19594-602 (2000).
RN [2]; RE0028372.
RX PUBMED: 11486036.
RA Yao Y. L., Yang W. M., Seto E.
RT Regulation of transcription factor YY1 by acetylation and deacetylation.
RL Mol. Cell. Biol. 21:5979-91 (2001).
RN [3]; RE0029293.
RX PUBMED: 11804585.
RA Fischle W., Dequiedt F., Hendzel M. J., Guenther M. G., Lazar M. A., Voelter W., Verdin E.
RT Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
RL Mol. Cell 9:45-57 (2002).
RN [4]; RE0029969.
RX PUBMED: 12724404.
RA Fleischer T. C., Yun U. J., Ayer D. E.
RT Identification and Characterization of Three New Components of the mSin3A Corepressor Complex.
RL Mol. Cell. Biol. 23:3456-67 (2003).
RN [5]; RE0035947.
RX PUBMED: 12527756.
RA Talukder A. H., Mishra S. K., Mandal M., Balasenthil S., Mehta S., Sahin A. A., Barnes C. J., Kumar R.
RT MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions.
RL J. Biol. Chem. 278:11676-11685 (2003).
RN [6]; RE0037668.
RX PUBMED: 15120635.
RA Geiman T. M., Sankpal U. T., Robertson A. K., Zhao Y., Zhao Y., Robertson K. D.
RT DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
RL Biochem. Biophys. Res. Commun. 318:544-55 (2004).
RN [7]; RE0038037.
RX PUBMED: 11739383.
RA Fischer D. D., Cai R., Bhatia U., Asselbergs F. A., Song C., Terry R., Trogani N., Widmer R., Atadja P., Cohen D.
RT Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10
RL J. Biol. Chem. 277:6656-66 (2002).
RN [8]; RE0038054.
RX PUBMED: 11777905.
RA Johnson C. A., White D. A., Lavender J. S., O Neill L. P., Turner B. M.
RT Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70
RL J. Biol. Chem. 277:9590-7 (2002).
RN [9]; RE0038073.
RX PUBMED: 11533236.
RA Amann J. M., Nip J., Strom D. K., Lutterbach B., Harada H., Lenny N., Downing J. R., Meyers S., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
RL Mol. Cell. Biol. 21:6470-83 (2001).
RN [10]; RE0038083.
RX PUBMED: 11466315.
RA Fischle W., Dequiedt F., Fillion M., Hendzel M. J., Voelter W., Verdin E.
RT Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
RL J. Biol. Chem. 276:35826-35 (2001).
RN [11]; RE0038125.
RX PUBMED: 11532945.
RA Yang W. M., Yao Y. L., Seto E.
RT The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1
RL EMBO J. 20:4814-25 (2001).
RN [12]; RE0040744.
RX PUBMED: 11171972.
RA You A., Tong J. K., Grozinger C. M., Schreiber S. L.
RT CoREST is an integral component of the CoREST- human histone deacetylase complex
RL Proc. Natl. Acad. Sci. USA 98:1454-8 (2001).
RN [13]; RE0044860.
RX PUBMED: 10581039.
RA van der Vlag J., Otte A. P.
RT Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
RL Nat. Genet. 23:474-8 (1999).
RN [14]; RE0047249.
RX PUBMED: 12398767.
RA Yang L., Mei Q., Zielinska-Kwiatkowska A., Matsui Y., Blackburn M. L., Benedetti D., Krumm A. A., Taborsky G. J. Jr, Chansky H. A.
RT An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B
RL Biochem. J. 369:651-7 (2003).
RN [15]; RE0047257.
RX PUBMED: 12032298.
RA Hakimi M. A., Bochar D. A., Chenoweth J., Lane W. S., Mandel G., Shiekhattar R.
RT A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes
RL Proc. Natl. Acad. Sci. USA 99:7420-5 (2002).
RN [16]; RE0047295.
RX PUBMED: 11062478.
RA Tsai S. C., Valkov N., Yang W. M., Gump J., Sullivan D., Seto E.
RT Histone deacetylase interacts directly with DNA topoisomerase II
RL Nat. Genet. 26:349-53 (2000).
RN [17]; RE0047547.
RX PUBMED: 11146623.
RA Mazumdar A., Wang R. A., Mishra S. K., Adam L., Bagheri-Yarmand R., Mandal M., Vadlamudi R. K., Kumar R.
RT Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
RL Nat. Cell Biol. 3:30-37 (2001).
RN [18]; RE0047766.
RX PUBMED: 11788710.
RA Vaute O., Nicolas E., Vandel L., Trouche D.
RT Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.
RL Nucleic Acids Res. 30:475-481 (2002).
RN [19]; RE0048105.
RX PUBMED: 12402037.
RA Bereshchenko O. R., Gu W., Dalla-Favera R.
RT Acetylation inactivates the transcriptional repressor BCL6.
RL Nat. Genet. 32:606-613 (2002).
RN [20]; RE0048151.
RX PUBMED: 14749338.
RA Zou J., Barahmand-pour F., Blackburn M. L., Matsui Y., Chansky H. A., Yang L.
RT Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.
RL J. Biol. Chem. 279:14922-14928 (2004).
RN [21]; RE0048159.
RX PUBMED: 16254079.
RA Zhang Y., Akinmade D., Hamburger A. W.
RT The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.
RL Nucleic Acids Res. 33:6024-6033 (2005).
RN [22]; RE0048205.
RX PUBMED: 10220405.
RA Yarden R. I., Brody L. C.
RT BRCA1 interacts with components of the histone deacetylase complex.
RL Proc. Natl. Acad. Sci. USA 96:4983-4988 (1999).
RN [23]; RE0048494.
RX PUBMED: 9819404.
RA Lutterbach B., Westendorf J. J., Linggi B., Patten A., Moniwa M., Davie J. R., Huynh K. D., Bardwell V. J., Lavinsky R. M., Rosenfeld M. G., Glass C., Seto E., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors.
RL Mol. Cell. Biol. 18:7176-7184 (1998).
RN [24]; RE0048550.
RX PUBMED: 15541729.
RA Sun J. M., Spencer V. A., Li L., Yu Chen H., Yu J., Davie J. R.
RT Estrogen regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins.
RL Exp. Cell Res. 302:96-107 (2005).
RN [25]; RE0052156.
RX PUBMED: 12176973.
RA Sun J. M., Chen H. Y., Moniwa M., Litchfield D. W., Seto E., Davie J. R.
RT The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
RL J. Biol. Chem. 277:35783-35786 (2002).
RN [26]; RE0052206.
RX PUBMED: 12082111.
RA Tsai S. C., Seto E.
RT Regulation of histone deacetylase 2 by protein kinase CK2.
RL J. Biol. Chem. 277:31826-31833 (2002).
RN [27]; RE0052309.
RX PUBMED: 10490602.
RA Lai A., Lee J. M., Yang W. M., DeCaprio J. A., Kaelin WG J. r., Seto E., Branton P. E.
RT RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.
RL Mol. Cell. Biol. 19:6632-6641 (1999).
RN [28]; RE0052535.
RX PUBMED: 10471499.
RA Ng H. H., Zhang Y., Hendrich B., Johnson C. A., Turner B. M., Erdjument-Bromage H., Tempst P., Reinberg D., Bird A.
RT MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.
RL Nat. Genet. 23:58-61 (1999).
RN [29]; RE0052627.
RX PUBMED: 12634383.
RA Knight J. S., Lan K., Subramanian C., Robertson E. S.
RT Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines.
RL J. Virol. 77:4261-4272 (2003).
RN [30]; RE0052707.
RX PUBMED: 15325272.
RA Iwase S., Januma A., Miyamoto K., Shono N., Honda A., Yanagisawa J., Baba T.
RT Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.
RL Biochem. Biophys. Res. Commun. 322:601-608 (2004).
RN [31]; RE0053121.
RX PUBMED: 18245468.
RA Yarosh W., Barrientos T., Esmailpour T., Lin L., Carpenter P. M., Osann K., Anton-Culver H., Huang T.
RT TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.
RL Cancer Res. 68:693-699 (2008).
RN [32]; RE0053133.
RX PUBMED: 15456747.
RA Jiang C. L., Jin S. G., Pfeifer G. P.
RT MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
RL J. Biol. Chem. 279:52456-52464 (2004).
RN [33]; RE0053192.
RX PUBMED: 12015313.
RA Koipally J., Georgopoulos K.
RT A molecular dissection of the repression circuitry of Ikaros.
RL J. Biol. Chem. 277:27697-27705 (2002).
RN [34]; RE0053243.
RX PUBMED: 12920132.
RA Yao Y. L., Yang W. M.
RT The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
RL J. Biol. Chem. 278:42560-42568 (2003).
RN [35]; RE0054177.
RX PUBMED: 12705869.
RA Fujita N., Jaye D. L., Kajita M., Geigerman C., Moreno C. S., Wade P. A.
RT MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
RL Cell 113:207-219 (2003).
RN [36]; RE0064761.
RX PUBMED: 17827154.
RA Sun J. M., Chen H. Y., Davie J. R.
RT Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.
RL J. Biol. Chem. 282:33227-33236 (2007).
RN [37]; RE0065030.
RX PUBMED: 14512427.
RA Lu Y., Goldenberg I., Bei L., Andrejic J., Eklund E. A.
RT HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2.
RL J. Biol. Chem. 278:47792-47802 (2003).
RN [38]; RE0067198.
RX PUBMED: 16387653.
RA Doyon Y., Cayrou C., Ullah M., Landry A. J., Cote V., Selleck W., Lane W. S., Tan S., Yang X. J., Cote J.
RT ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
RL Mol. Cell 21:51-64 (2006).
RN [39]; RE0071767.
RX PUBMED: 20534591.
RA Kim Y., Park H., Park D., Lee Y. S., Choe J., Hahn J. H., Lee H., Kim Y. M., Jeoung D.
RT Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.
RL J. Biol. Chem. 285:25957-25968 (2010).
RN [40]; RE0072566.
RX PUBMED: 21549307.
RA Rowbotham S. P., Barki L., Neves-Costa A., Santos F., Dean W., Hawkes N., Choudhary P., Will W. R., Webster J., Oxley D., Green C. M., Varga-Weisz P., Mermoud J. E.
RT Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
RL Mol. Cell 42:285-296 (2011).
XX
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