AC T14622
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ID T14622
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DT 12.04.2002 (created); spi.
DT 05.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA sin3a
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SY Histone deacetylase complex subunit Sin3a; paired amphipathic helix protein Sin3a; SIN3 homolog A, transcriptional regulator (yeast); Sin3a; transcriptional co-repressor Sin3A.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005255 SIN3A; HGNC: Sin3a.
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IN T02245 AML1b; human, Homo sapiens.
IN T18773 BCAA-isoform1; human, Homo sapiens.
IN T18775 BCAA; human, Homo sapiens.
IN T21924 BCL-11A; human, Homo sapiens.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T01261 Brm; human, Homo sapiens.
IN T04643 c-Ski; human, Homo sapiens.
IN T34265 COPS2; human, Homo sapiens.
IN T09170 CtBP1-isoform1; human, Homo sapiens.
IN T14623 Ebp1; Mammalia.
IN T25772 ESET-isoform1; mouse, Mus musculus.
IN T25815 ESET-isoform5; mouse, Mus musculus.
IN T10390 FKLF-isoform1; human, Homo sapiens.
IN T01088 FOXK2a; human, Homo sapiens.
IN T00118 HCF1-isoform1; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T08343 HDAC1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T04109 hdac2-isoform1; human, Homo sapiens.
IN T25625 hdac2; human, Homo sapiens.
IN T23085 Mad1; Mammalia.
IN T04936 MECP-2; human, Homo sapiens.
IN T16997 MTG8; human, Homo sapiens.
IN T25701 MTG8B; human, Homo sapiens.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T00671 p53; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T06377 PML; human, Homo sapiens.
IN T08171 PSF; human, Homo sapiens.
IN T22425 RCOR1; human, Homo sapiens.
IN T18280 REST-isoform1; human, Homo sapiens.
IN T10469 REST; Mammalia.
IN T08348 RXR-alpha; mouse, Mus musculus.
IN T34689 SAP130-isoform1; human, Homo sapiens.
IN T34366 SAP130; human, Homo sapiens.
IN T28755 SAP30; human, Homo sapiens.
IN T08501 T3R-alpha; chick, Gallus gallus.
IN T19290 Tal-1; human, Homo sapiens.
IN T27798 Tal-1; Mammalia.
IN T09156 TGIF-isoform2; human, Homo sapiens.
IN T10218 TGIF1-isoform1; mouse, Mus musculus.
IN T04077 TGIF; mouse, Mus musculus.
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MX M04756 V$SIN3A_01.
MX M04799 V$SIN3A_03.
MX M04906 V$SIN3A_04.
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BS R24843.
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DR TRANSPATH: MO000030983.
DR SMARTDB: SB000106.
DR UniProtKB: Q96ST3; SN3A_HUMAN.
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RN [1]; RE0024625.
RX PUBMED: 9620804.
RA Nan X., Ng H.-H., Johnson C. A., Laherty C. D., Turner B. M., Eisenman R. N., Bird A.
RT Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
RL Nature 393:386-389 (1998).
RN [2]; RE0026561.
RX PUBMED: 10766745.
RA Koipally J., Georgopoulos K.
RT Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
RL J. Biol. Chem. 275:19594-602 (2000).
RN [3]; RE0027552.
RX PUBMED: 10640275.
RA Huang E. Y., Zhang J., Miska E. A., Guenther M. G., Kouzarides T., Lazar M. A.
RT Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
RL Genes Dev. 14:45-54 (2000).
RN [4]; RE0028247.
RX PUBMED: 11430826.
RA Khan M. M., Nomura T., Kim H., Kaul S. C., Wadhwa R., Shinagawa T., Ichikawa-Iwata E., Zhong S., Pandolfi P. P., Ishii S.
RT Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
RL Mol. Cell 7:1233-43 (2001).
RN [5]; RE0028350.
RX PUBMED: 11302704.
RA Taplick J., Kurtev V., Kroboth K., Posch M., Lechner T., Seiser C.
RT Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.
RL J. Mol. Biol. 308:27-38 (2001).
RN [6]; RE0029026.
RX PUBMED: 11682623.
RA Sharma M., Sun Z.
RT 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription.
RL Mol. Endocrinol. 15:1918-28 (2001).
RN [7]; RE0029969.
RX PUBMED: 12724404.
RA Fleischer T. C., Yun U. J., Ayer D. E.
RT Identification and Characterization of Three New Components of the mSin3A Corepressor Complex.
RL Mol. Cell. Biol. 23:3456-67 (2003).
RN [8]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
RN [9]; RE0035566.
RX PUBMED: 10688671.
RA Huang S., Brandt S. J.
RT mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.
RL Mol. Cell. Biol. 20:2248-2259 (2000).
RN [10]; RE0037672.
RX PUBMED: 15148359.
RA Geiman T. M., Sankpal U. T., Robertson A. K., Chen Y., Mazumdar M., Heale J. T., Schmiesing J. A., Kim W., Yokomori K., Zhao Y., Robertson K. D.
RT Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery
RL Nucleic Acids Res. 32:2716-29 (2004).
RN [11]; RE0038632.
RX PUBMED: 11585818.
RA Satou A., Taira T., Iguchi-Ariga S. M., Ariga H.
RT A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein
RL J. Biol. Chem. 276:46562-7 (2001).
RN [12]; RE0039460.
RX PUBMED: 10617663.
RA Lutterbach B., Westendorf J. J., Linggi B., Isaac S., Seto E., Hiebert S. W.
RT A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
RL J. Biol. Chem. 275:651-6 (2000).
RN [13]; RE0040744.
RX PUBMED: 11171972.
RA You A., Tong J. K., Grozinger C. M., Schreiber S. L.
RT CoREST is an integral component of the CoREST- human histone deacetylase complex
RL Proc. Natl. Acad. Sci. USA 98:1454-8 (2001).
RN [14]; RE0045656.
RX PUBMED: 12391155.
RA Yochum G. S., Ayer D. E.
RT Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split
RL Mol. Cell. Biol. 22:7868-76 (2002).
RN [15]; RE0047249.
RX PUBMED: 12398767.
RA Yang L., Mei Q., Zielinska-Kwiatkowska A., Matsui Y., Blackburn M. L., Benedetti D., Krumm A. A., Taborsky G. J. Jr, Chansky H. A.
RT An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B
RL Biochem. J. 369:651-7 (2003).
RN [16]; RE0047677.
RX PUBMED: 11259580.
RA Mathur M., Tucker P. W., Samuels H. H.
RT PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
RL Mol. Cell. Biol. 21:2298-2311 (2001).
RN [17]; RE0047881.
RX PUBMED: 15451426.
RA Nikolaev A. Y., Papanikolaou N. A., Li M., Qin J., Gu W.
RT Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.
RL Biochem. Biophys. Res. Commun. 323:1216-1222 (2004).
RN [18]; RE0047884.
RX PUBMED: 14525983.
RA Wu K., Yang Y., Wang C., Davoli M. A., D'Amico M., Li A., Cveklova K., Kozmik Z., Lisanti M. P., Russell R. G., Cvekl A., Pestell R. G.
RT DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
RL J. Biol. Chem. 278:51673-51684 (2003).
RN [19]; RE0048072.
RX PUBMED: 12529406.
RA Yamagoe S., Kanno T., Kanno Y., Sasaki S., Siegel R. M., Lenardo M. J., Humphrey G., Wang Y., Nakatani Y., Howard B. H., Ozato K.
RT Interaction of histone acetylases and deacetylases in vivo.
RL Mol. Cell. Biol. 23:1025-1033 (2003).
RN [20]; RE0048074.
RX PUBMED: 11283259.
RA Yang S. H., Vickers E., Brehm A., Kouzarides T., Sharrocks A. D.
RT Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.
RL Mol. Cell. Biol. 21:2802-2814 (2001).
RN [21]; RE0048151.
RX PUBMED: 14749338.
RA Zou J., Barahmand-pour F., Blackburn M. L., Matsui Y., Chansky H. A., Yang L.
RT Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.
RL J. Biol. Chem. 279:14922-14928 (2004).
RN [22]; RE0048154.
RX PUBMED: 10984530.
RA Downes M., Ordentlich P., Kao H. Y., Alvarez J. G., Evans R. M.
RT Identification of a nuclear domain with deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 97:10330-10335 (2000).
RN [23]; RE0048159.
RX PUBMED: 16254079.
RA Zhang Y., Akinmade D., Hamburger A. W.
RT The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.
RL Nucleic Acids Res. 33:6024-6033 (2005).
RN [24]; RE0048202.
RX PUBMED: 10734093.
RA Grimes J. A., Nielsen S. J., Battaglioli E., Miska E. A., Speh J. C., Berry D. L., Atouf F., Holdener B. C., Mandel G., Kouzarides T.
RT The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
RL J. Biol. Chem. 275:9461-9467 (2000).
RN [25]; RE0048203.
RX PUBMED: 10688661.
RA Roopra A., Sharling L., Wood I. C., Briggs T., Bachfischer U., Paquette A. J., Buckley N. J.
RT Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex.
RL Mol. Cell. Biol. 20:2147-2157 (2000).
RN [26]; RE0048493.
RX PUBMED: 11150306.
RA Hildebrand D., Tiefenbach J., Heinzel T., Grez M., Maurer A. B.
RT Multiple regions of ETO cooperate in transcriptional repression.
RL J. Biol. Chem. 276:9889-9895 (2001).
RN [27]; RE0048494.
RX PUBMED: 9819404.
RA Lutterbach B., Westendorf J. J., Linggi B., Patten A., Moniwa M., Davie J. R., Huynh K. D., Bardwell V. J., Lavinsky R. M., Rosenfeld M. G., Glass C., Seto E., Hiebert S. W.
RT ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors.
RL Mol. Cell. Biol. 18:7176-7184 (1998).
RN [28]; RE0049111.
RX PUBMED: 16421255.
RA Tiefenbach J., Novac N., Ducasse M., Eck M., Melchior F., Heinzel T.
RT SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
RL Mol. Biol. Cell 17:1643-1651 (2006).
RN [29]; RE0052535.
RX PUBMED: 10471499.
RA Ng H. H., Zhang Y., Hendrich B., Johnson C. A., Turner B. M., Erdjument-Bromage H., Tempst P., Reinberg D., Bird A.
RT MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.
RL Nat. Genet. 23:58-61 (1999).
RN [30]; RE0052627.
RX PUBMED: 12634383.
RA Knight J. S., Lan K., Subramanian C., Robertson E. S.
RT Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines.
RL J. Virol. 77:4261-4272 (2003).
RN [31]; RE0053648.
RX PUBMED: 11719366.
RA Ward J. O., McConnell M. J., Carlile G. W., Pandolfi P. P., Licht J. D., Freedman L. P.
RT The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor.
RL Blood 98:3290-3300 (2001).
RN [32]; RE0055633.
RX PUBMED: 16805913.
RA Brown M. A., Sims RJ 3. r. d., Gottlieb P. D., Tucker P. W.
RT Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
RL Mol. Cancer 5:26 (2006).
RN [33]; RE0062796.
RX PUBMED: 15199122.
RA Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D. J., Kitabayashi I., Herr W., Cleary M. L.
RT Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.
RL Mol. Cell. Biol. 24:5639-5649 (2004).
RN [34]; RE0064761.
RX PUBMED: 17827154.
RA Sun J. M., Chen H. Y., Davie J. R.
RT Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.
RL J. Biol. Chem. 282:33227-33236 (2007).
RN [35]; RE0067198.
RX PUBMED: 16387653.
RA Doyon Y., Cayrou C., Ullah M., Landry A. J., Cote V., Selleck W., Lane W. S., Tan S., Yang X. J., Cote J.
RT ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
RL Mol. Cell 21:51-64 (2006).
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