AC T18280
XX
ID T18280
XX
DT 07.09.2006 (created); sri.
DT 28.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA REST-isoform1
XX
SY neural-restrictive silencer factor; NRSF; RE1-silencing transcription factor; REST; REST protein; XBR.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G009401 REST; HGNC: REST.
XX
CL C0001; CH; 2.3.4.0.27.1.
XX
SZ 1097 AA; 121.9 kDa (cDNA) (calc.).
XX
SQ MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNG
SQ SCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVE
SQ PQPVFEASGAPDIYSSNKDLPPETPGAEDKGKSSKTKPFRCKPCQYEAESEEQFVHHIRV
SQ HSAKKFFVEESAEKQAKARESGSSTAEEGDFSKGPIRCDRCGYNTNRYDHYTAHLKHHTR
SQ AGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCGKCNYFSDRKNNYVQHVRTHTG
SQ ERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCSYVASNQHEVTRHARQVHNGPKP
SQ LNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPNKTM
SQ DVSKVKLKKTKKREADLPDNITNEKTEIEQTKIKGDVAGKKNEKSVKAEKRDVSKEKKPS
SQ NNVSVIQVTTRTRKSVTEVKEMDVHTGSNSEKFSKTKKSKRKLEVDSHSLHGPVNDEESS
SQ TKKKKKVESKSKNNSQEVPKGDSKVEENKKQNTCMKKSTKKKTLKNKSSKKSSKPPQKEP
SQ VEKGSAQMDPPQMGPAPTEAVQKGPVQVELPPPMEHAQMEGAQIRPAPDEPVQMEVVQEG
SQ PAQKELLPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAP
SQ MQVVQKEPVQMELSPPMEVVQKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQKEPVQME
SQ LSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLRKDKKEKSNMQSERARKEQVLIEV
SQ GLVPVKDSWLLKESVSTEDLSPPSPPLPKENLREEASGDQKLLNTGEGNKEAPLQKVGAE
SQ EADESLPGLAANINESTHISSSGQNLNTPEGETLNGKHQTDSIVCEMKMDTDQNTRENLT
SQ GINSTVEEPVSPMLPPSAVEEREAVSKTALASPPATMAANESQEIDEDEGIHSHEGSDLS
SQ DNMSEGSDDSGLHGARPVPQESSRKNAKEALAVKAAKGDFVCIFCDRSFRKGKDYSKHLN
SQ RHLVNVYYLEEAAQGQE
XX
SC translated from EMBL:U22314
XX
FT 159 181 
SM00355; c2h2final6.
FT 159 186 
PS50157; ZINC_FINGER_C2H2_2.
FT 216 238 
SM00355; c2h2final6.
FT 248 270 
SM00355; c2h2final6.
FT 276 298 
PF00096; zf-C2H2.
FT 276 298 
SM00355; c2h2final6.
FT 276 303 
PS50157; ZINC_FINGER_C2H2_2.
FT 304 326 
PF00096; zf-C2H2.
FT 304 326 
SM00355; c2h2final6.
FT 304 331 
PS50157; ZINC_FINGER_C2H2_2.
FT 332 355 PF00096; zf-C2H2.
FT 332 355 SM00355; c2h2final6.
FT 332 360 PS50157; ZINC_FINGER_C2H2_2.
FT 361 383 PF00096; zf-C2H2.
FT 361 383 SM00355; c2h2final6.
FT 361 388 PS50157; ZINC_FINGER_C2H2_2.
FT 389 412 PF00096; zf-C2H2.
FT 389 412 SM00355; c2h2final6.
FT 1060 1082 PF00096; zf-C2H2.
FT 1060 1082 PS50157; ZINC_FINGER_C2H2_2.
FT 1060 1082 SM00355; c2h2final6.
XX
CP most non-neuronal and undifferentiated neural precursor cells.
XX
FF repressor of neural and non-neural genes [1] [2];
XX
IN T22425 RCOR1; human, Homo sapiens.
IN T14622 sin3a; human, Homo sapiens.
XX
MX M00325 V$NRSE_B.
MX M00256 V$NRSF_01.
MX M01028 V$NRSF_Q4.
XX
BS R07753.
BS R07754.
BS R07755.
BS R07756.
BS R07757.
BS R07758.
BS R07759.
BS R07760.
BS R07761.
BS R07762.
BS R07763.
BS R07764.
BS R07765.
BS R07766.
BS R07767.
BS R07768.
BS R07769.
BS R07770.
BS R07771.
BS R07772.
BS R07773.
BS R07774.
BS R07775.
BS R07776.
BS R07777.
BS R07778.
BS R07779.
BS R07780.
BS R04606.
XX
DR TRANSPATH: MO000086596.
DR EMBL: U13879;
DR EMBL: U22314;
DR UniProtKB: Q13127-1; ST_HUMAN.
XX
RN [1]; RE0004782.
RX PUBMED: 8790425.
RA Schoenherr C. J., Paquette A. J., Anderson D. J.
RT Identification of potential target genes for the neuron-restrictive silencer factor
RL Proc. Natl. Acad. Sci. USA 93:9881-9886 (1996).
RN [2]; RE0004805.
RX PUBMED: 7871435.
RA Schoenherr C. J., Anderson D. J.
RT The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
RL Science 267:1360-1363 (1995).
RN [3]; RE0048202.
RX PUBMED: 10734093.
RA Grimes J. A., Nielsen S. J., Battaglioli E., Miska E. A., Speh J. C., Berry D. L., Atouf F., Holdener B. C., Mandel G., Kouzarides T.
RT The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
RL J. Biol. Chem. 275:9461-9467 (2000).
RN [4]; RE0048203.
RX PUBMED: 10688661.
RA Roopra A., Sharling L., Wood I. C., Briggs T., Bachfischer U., Paquette A. J., Buckley N. J.
RT Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex.
RL Mol. Cell. Biol. 20:2147-2157 (2000).
RN [5]; RE0048211.
RX PUBMED: 7697725.
RA Chong J. A., Tapia-Ramirez J., Kim S., Toledo-Aral J. J., Zheng Y., Boutros M. C., Altshuller Y. M., Frohman M. A., Kraner S. D., Mandel G.
RT REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.
RL Cell 80:949-957 (1995).
XX
//