AC T09156
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ID T09156
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DT 31.07.2006 (created); jag.
DT 08.03.2007 (updated); sou.
CO Copyright (C), QIAGEN.
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FA TGIF-isoform2
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SY 5'-TG-3' interacting factor; 5'TG3' interacting factor; TG-interacting factor; TGIF1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002125 TGIF1; HGNC: TGIF1.
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CL C0006; homeo; 3.1.4.6.1.2.
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SZ 272 AA; 29.7 kDa (cDNA) (calc.).
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SQ MKGKKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYN
SQ AYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISET
SQ SSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTA
SQ LKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTP
SQ PDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
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SC translated from EMBL #X89750
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FT 1 63 
repression domain [6].
FT 33 96 
PS50071; HOMEOBOX_2.
FT 35 100 
SM00389; HOX_1.
FT 36 95 
PF00046; Homeobox domain.
FT 108 192 
HDAC1T04106 interaction domain [5].
FT 138 192 
Smad T04095 interaction domain (SID) [6].
FT 192 272 
repression domain [6].
FT 235 235 
MAP kinase phosphorylation site (T235) [8].
FT 235 241 
putative SH3 binding domain [3].
FT 239 239 
MAP kinase phosphorylation site (T239) [8].
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IN T08487 AR-isoform1; human, Homo sapiens.
IN T14622 sin3a; human, Homo sapiens.
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MX M00418 V$TGIF_01.
MX M01346 V$TGIF_02.
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BS R09609.
BS R09610.
BS R09611.
BS R09612.
BS R09613.
BS R09614.
BS R09615.
BS R09616.
BS R09617.
BS R09618.
BS R09619.
BS R09620.
BS R09621.
BS R09622.
BS R09623.
BS R09633.
BS R03931.
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DR TRANSPATH: MO000083920.
DR EMBL: AF179900;
DR EMBL: X89750;
DR UniProtKB: Q15583-2;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015443.
RX PUBMED: 10835638.
RA Gripp K. W., Wotton D., Edwards M. C., Roessler E., Ades L., Meinecke P., Richieri-Costa A., Zackai E. H., Massague J., Muenke M., Elledge S. J.
RT Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination
RL Nat. Genet. 25:205-208 (2000).
RN [3]; RE0015444.
RX PUBMED: 8537382.
RA Bertolino E., Reimund B., Wildt-Perinic D., Clerc R. G.
RT A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif
RL J. Biol. Chem. 270:31178-31188 (1995).
RN [4]; RE0015454.
RX PUBMED: 9383053.
RA Edwards M. C., Liegeois N., Horecka J., DePinho R. A., Sprague GF J. r., Tyers M., Elledge S. J.
RT Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells
RL Genetics 147:1063-1076 (1997).
RN [5]; RE0015455.
RX PUBMED: 10601270.
RA Wotton D., Lo R. S., Swaby L. A., Massague J.
RT Multiple modes of repression by the Smad transcriptional corepressor TGIF
RL J. Biol. Chem. 274:37105-37110 (1999).
RN [6]; RE0015456.
RX PUBMED: 10199400.
RA Wotton D., Lo R. S., Lee S., Massague J.
RT A Smad transcriptional corepressor
RL Cell 97:29-39 (1999).
RN [7]; RE0015476.
RX PUBMED: 10764806.
RA Yang Y., Hwang C. K., D'Souza U. M., Lee S. H., Junn E., Mouradian M. M.
RT Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription
RL J. Biol. Chem. 275:20734-20741 (2000).
RN [8]; RE0016125.
RX PUBMED: 11226163.
RA Lo R. S., Wotton D., Massague J.
RT Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF
RL EMBO J. 20:128-136 (2001).
RN [9]; RE0029026.
RX PUBMED: 11682623.
RA Sharma M., Sun Z.
RT 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription.
RL Mol. Endocrinol. 15:1918-28 (2001).
RN [10]; RE0047925.
RX PUBMED: 11427533.
RA Melhuish T. A., Gallo C. M., Wotton D.
RT TGIF2 interacts with histone deacetylase 1 and represses transcription.
RL J. Biol. Chem. 276:32109-32114 (2001).
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