AC T08501
XX
ID T08501
XX
DT 30.01.2006 (created); din.
DT 14.01.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA T3R-alpha
XX
SY c-ErbA; c-ErbA-alpha; NR1A1; T3R; T3R-alpha; THRA; thyroid hormone receptor; thyroid hormone receptor alpha; TR; TRalpha.
XX
OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
XX
GE G031448 THRA.
XX
CL C0002; CC (rec).
XX
SZ 408 AA; 46.8 kDa (cDNA) (calc.).
XX
SQ MEQKPSTLDPLSEPEDTRWLDGKRKRKSSQCLVKSSMSGYIPSYLDKDEQCVVCGDKATG
SQ YHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDGCCVIDKITRNQCQLCRFKKCISVGMAM
SQ DLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQG
SQ SHWKQKRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSEL
SQ PCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDL
SQ GKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQETYLLAFEHYINYRKHNIPH
SQ FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV
XX
SC translated from EMBL #Y00987
XX
FT 48 121 
SM00399; c4gold.
FT 48 125 
PS51030; NUCLEAR_REC_DBD_2.
FT 49 126 
PF00105; Zinc finger, C4 type (two domains).
FT 87 327 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 218 376 
SM00430; holi.
FT 221 402 
PF00104; Ligand-binding domain of nuclear hormon.
XX
IN T08796 ASC-2; human, Homo sapiens.
IN T09920 CREB1; Mammalia.
IN T08865 ctcf-isoform1; human, Homo sapiens.
IN T02285 ctcf; mouse, Mus musculus.
IN T25707 FUS-L; human, Homo sapiens.
IN T08490 MO15; human, Homo sapiens.
IN T04687 NCOR1; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T01516 Pit-1B; rat, Rattus norvegicus.
IN T08891 PSF-isoform1; human, Homo sapiens.
IN T08348 RXR-alpha; mouse, Mus musculus.
IN T01349 RXR-beta; rat, Rattus norvegicus.
IN T14622 sin3a; human, Homo sapiens.
IN T19112 SMRT-xbb2; human, Homo sapiens.
IN T08781 SRB7; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
IN T08256 SRC-1A; human, Homo sapiens.
IN T08500 SRC3-xbb1; human, Homo sapiens.
IN T15900 SREBP-1; chick, Gallus gallus.
IN T08439 TIF2; mouse, Mus musculus.
IN T13796 TLS; human, Homo sapiens.
IN T19456 ZNF277; human, Homo sapiens.
XX
MX M01724 V$T3RALPHA_Q6.
MX M00963 V$T3R_Q6.
XX
BS R03943.
BS R20561.
BS R20562.
BS R20567.
BS R27672.
BS R02019.
BS R03946.
BS R03947.
BS R03948.
BS R03949.
BS R03950.
BS R03951.
BS R04808.
BS R11623.
BS R11625.
BS R11628.
BS R11630.
BS R11631.
BS R11632.
BS R11633.
BS R11634.
BS R11635.
BS R10034.
BS R04090.
BS R01673.
BS R38689.
BS R20190.
BS R03956.
BS R28235.
BS R29449.
BS R20170.
BS R29251.
BS R29341.
BS R65765.
BS R30887.
BS R30888.
BS R08504.
BS R29247.
BS R60510.
BS R29372.
BS R65764.
BS R65766.
BS R29253.
BS R20554.
BS R60517.
BS R29570.
BS R38691.
BS R19722.
BS R29451.
BS R04185.
XX
DR TRANSPATH: MO000059132.
DR EMBL: Y00987;
DR UniProtKB: P04625;
XX
RN [1]; RE0047519.
RX PUBMED: 15249124.
RA Nevado J., Tenbaum S. P., Aranda A.
RT hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.
RL Mol. Cell. Endocrinol. 222:41-51 (2004).
RN [2]; RE0047527.
RX PUBMED: 10866662.
RA Mahajan M. A., Samuels H. H.
RT A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.
RL Mol. Cell. Biol. 20:5048-5063 (2000).
RN [3]; RE0047643.
RX PUBMED: 10625678.
RA Perez-Juste G., Garcia-Silva S., Aranda A.
RT An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells.
RL J. Biol. Chem. 275:1307-1314 (2000).
RN [4]; RE0047677.
RX PUBMED: 11259580.
RA Mathur M., Tucker P. W., Samuels H. H.
RT PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
RL Mol. Cell. Biol. 21:2298-2311 (2001).
RN [5]; RE0047681.
RX PUBMED: 9372952.
RA Qi J. S., Desai-Yajnik V., Yuan Y., Samuels H. H.
RT Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.
RL Mol. Cell. Biol. 17:7195-7207 (1997).
RN [6]; RE0047685.
RX PUBMED: 10490654.
RA Li D., Desai-Yajnik V., Lo E., Schapira M., Abagyan R., Samuels H. H.
RT NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors.
RL Mol. Cell. Biol. 19:7191-7202 (1999).
RN [7]; RE0047692.
RX PUBMED: 12805224.
RA Mendez-Pertuz M., Sanchez-Pacheco A., Aranda A.
RT The thyroid hormone receptor antagonizes CREB-mediated transcription.
RL EMBO J. 22:3102-3112 (2003).
RN [8]; RE0047710.
RX PUBMED: 9440806.
RA Powers C. A., Mathur M., Raaka B. M., Ron D., Samuels H. H.
RT TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.
RL Mol. Endocrinol. 12:4-18 (1998).
RN [9]; RE0067795.
RX PUBMED: 18187603.
RA Yamauchi M., Kambe F., Cao X., Lu X., Kozaki Y., Oiso Y., Seo H.
RT Thyroid hormone activates adenosine 5'-monophosphate-activated protein kinase via intracellular calcium mobilization and activation of calcium/calmodulin-dependent protein kinase kinase-beta.
RL Mol. Endocrinol. 22:893-903 (2008).
XX
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