AC T08865
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ID T08865
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DT 26.04.2006 (created); man.
DT 26.08.2014 (updated); hna.
CO Copyright (C), QIAGEN.
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FA ctcf-isoform1
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SY CCCTC-binding factor; ctcf.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013845 CTCF; HGNC: CTCF.
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CL C0001; CH.
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SZ 727 AA; 82.8 kDa (cDNA) (calc.), 160 kDa (SDS) [4]
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SQ MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQM
SQ VMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPV
SQ PVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQ
SQ GELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEV
SQ NAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCG
SQ RAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYAS
SQ VEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSG
SQ TMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERY
SQ ALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDM
SQ HFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEGENGGETKKSKRGRKR
SQ KMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTN
SQ QPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEM
SQ ILSMMDR
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SC translated from EMBL:U25435
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FT 266 288 
PF00096; zf-C2H2.
FT 266 288 
SM00355; c2h2final6.
FT 266 293 
PS50157; ZINC_FINGER_C2H2_2.
FT 294 316 
PF00096; zf-C2H2.
FT 294 316 
SM00355; c2h2final6.
FT 294 321 
PS50157; ZINC_FINGER_C2H2_2.
FT 322 345 
PF00096; zf-C2H2.
FT 322 345 
SM00355; c2h2final6.
FT 322 350 
PS50157; ZINC_FINGER_C2H2_2.
FT 351 373 
PF00096; zf-C2H2.
FT 351 373 SM00355; c2h2final6.
FT 351 378 PS50157; ZINC_FINGER_C2H2_2.
FT 379 401 PF00096; zf-C2H2.
FT 379 401 SM00355; c2h2final6.
FT 379 406 PS50157; ZINC_FINGER_C2H2_2.
FT 407 430 PF00096; zf-C2H2.
FT 407 430 SM00355; c2h2final6.
FT 407 435 PS50157; ZINC_FINGER_C2H2_2.
FT 437 460 PF00096; zf-C2H2.
FT 437 460 SM00355; c2h2final6.
FT 437 465 PS50157; ZINC_FINGER_C2H2_2.
FT 467 489 PF00096; zf-C2H2.
FT 467 489 SM00355; c2h2final6.
FT 467 494 PS50157; ZINC_FINGER_C2H2_2.
FT 495 517 PF00096; zf-C2H2.
FT 495 517 SM00355; c2h2final6.
FT 495 522 PS50157; ZINC_FINGER_C2H2_2.
FT 523 546 PF00096; zf-C2H2.
FT 523 546 PS50157; ZINC_FINGER_C2H2_2.
FT 523 546 SM00355; c2h2final6.
FT 555 573 PS50157; ZINC_FINGER_C2H2_2.
FT 555 575 SM00355; c2h2final6.
FT 555 577 PF00096; zf-C2H2.
FT 649 661 PF02178; AT_hook.
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SF zinc fingers 5 to 7 and 3 to 8 are essential for binding to APB beta and c-myc promoter sites respectively [2];
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IN T08865 ctcf-isoform1; human, Homo sapiens.
IN T01334 RXR-beta; human, Homo sapiens.
IN T08501 T3R-alpha; chick, Gallus gallus.
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MX M01259 V$CTCF_02.
MX M02242 V$CTCF_03.
MX M07249 V$CTCF_Q3_01.
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BS R23819.
BS R24027.
BS R23810.
BS R24029.
BS R04529.
BS R24016.
BS R20969.
BS R63525.
BS R63444.
BS R63469.
BS R63605.
BS R04520.
BS R04522.
BS R24015.
BS R24266.
BS R24021.
BS R24018.
BS R18681.
BS R18682.
BS R24022.
BS R23815.
BS R24023.
BS R24025.
BS R24444.
BS R24445.
BS R36114.
BS R04524.
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DR TRANSPATH: MO000080639.
DR EMBL: U25435; HSU25435.
DR UniProtKB: P49711; CTCF_HUMAN.
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RN [1]; RE0047643.
RX PUBMED: 10625678.
RA Perez-Juste G., Garcia-Silva S., Aranda A.
RT An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells.
RL J. Biol. Chem. 275:1307-1314 (2000).
RN [2]; RE0051519.
RX PUBMED: 10954607.
RA Quitschke W. W., Taheny M. J., Fochtmann L. J., Vostrov A. A.
RT Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene.
RL Nucleic Acids Res. 28:3370-3378 (2000).
RN [3]; RE0052642.
RX PUBMED: 11782357.
RA Filippova G. N., Qi C. F., Ulmer J. E., Moore J. M., Ward M. D., Hu Y. J., Loukinov D. I., Pugacheva E. M., Klenova E. M., Grundy P. E., Feinberg A. P., Cleton-Jansen A. M., Moerland E. W., Cornelisse C. J., Suzuki H., Komiya A., Lindblom A., Dorion-Bonnet F., Neiman P. E., Morse HC 3. r. d., Collins S. J., Lobanenkov V. V.
RT Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.
RL Cancer Res. 62:48-52 (2002).
RN [4]; RE0006319.
RX PUBMED: 8649389.
RA Filippova G. N., Fagerlie S., Klenova E. M., Meyers C., Dehner Y., Goodwin G., Neiman P. E., Collins S. J., Lobanenkov V. V.
RT An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
RL Mol. Cell. Biol. 16:2802-2813 (1996).
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