AC T08500
XX
ID T08500
XX
DT 30.01.2006 (created); rad.
DT 07.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA SRC3-xbb1
XX
SY ACTR; ACTR/RAC3/AIB1/TRAM-1; AIB1; CAGH16; CTG26; NCOA3; nuclear receptor coactivator 3; p/CIP; pCIP; RAC3; SRC3; steroid receptor coactivator-3; TNRC14; TNRC16; TRAM-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002759 NCOA3; HGNC: NCOA3.
XX
CL C0010; bHLH.
XX
SZ 1412 AA; 154.1 kDa (cDNA) (calc.).
XX
SQ MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
SQ NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
SQ LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
SQ VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
SQ DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
SQ IQRFFSLNDGQSWSQKRHYQEVTSDGIFSPTAYLNGHAETPVYRFSLADGTIVTAQTKSK
SQ LFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQ
SQ MPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYRLNMSSPPHGS
SQ PGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAIS
SQ EGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSR
SQ DHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESS
SQ VSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDT
SQ SSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCT
SQ SSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQV
SQ FQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPR
SQ MMDSQENYGSSMGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRS
SQ NSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQ
SQ NRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQG
SQ QALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQ
SQ GNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAV
SQ MRPMMQPQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQ
SQ QQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPP
SQ NAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVYSM
SQ VHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
XX
SC tranlsated from EMBL #AF036892
XX
FT 1 300 
PAS/ bHLH [3].
FT 15 83 
PS50888; HLH.
FT 28 83 
PF00010; Helix-loop-helix DNA-binding domain.
FT 31 88 
SM00353; finulus.
FT 55 1090 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 112 178 
SM00091; pas_2.
FT 117 180 
PS50112; PAS.
FT 621 728 
N-terminal RID [3].
FT 621 821 
RID (receptor interaction domain) [3].
FT 729 821 
C-terminal RID [3].
FT 1018 1088 CID [3].
FT 1088 1412 HAT (histone acetyltransferase) activity [3].
FT 1279 1336 PF07469; Domain of unknown function (DUF1518).
XX
IN T08525 LRH1-isoform1; human, Homo sapiens.
IN T08501 T3R-alpha; chick, Gallus gallus.
XX
DR TRANSPATH: MO000059025.
DR EMBL: AF036892;
DR UniProtKB: Q9Y6Q9;
XX
RN [1]; RE0035956.
RX PUBMED: 15143151.
RA Xu P. L., Liu Y. Q., Shan S. F., Kong Y. Y., Zhou Q., Li M., Ding J. P., Xie Y. H., Wang Y.
RT Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.
RL Mol. Endocrinol. 18:1887-1905 (2004).
RN [2]; RE0047692.
RX PUBMED: 12805224.
RA Mendez-Pertuz M., Sanchez-Pacheco A., Aranda A.
RT The thyroid hormone receptor antagonizes CREB-mediated transcription.
RL EMBO J. 22:3102-3112 (2003).
RN [3]; RE0016535.
RX PUBMED: 9267036.
RA Chen H., Lin R. J., Schiltz R. L., Chakravarti D., Nash A., Nagy L., Privalsky M. L., Nakatani Y., Evans R. M.
RT Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
RL Cell 90:569-580 (1997).
XX
//