AC T08525
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ID T08525
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DT 30.01.2006 (created); rad.
DT 08.04.2009 (updated); mka.
CO Copyright (C), QIAGEN.
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FA LRH1-isoform1
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SY alpha-1-fetoprotein transcription factor; B1-binding factor; B1F; B1F2; CPF; CYP7A promoter binding factor; FTF; Ftz-F1; FTZ-F1beta; HB1F; hB1F-2; hepatocytic transcription factor; LRH-1; LRH-1 isoform 1; NR5A2; nuclear receptor subfamily 5, group A, member 2; Orphan nuclear receptor NR5A2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002482 NR5A2; HGNC: NR5A2.
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CL C0002; CC (rec); 2.1.5.0.2.1.
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SZ 495 AA; 56.5 kDa (cDNA) (calc.).
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SQ MSSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESC
SQ KGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRN
SQ KFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLN
SQ HAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMG
SQ YSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMC
SQ KMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLV
SQ TGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLEN
SQ FQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDV
SQ PYNNLLIEMLHAKRA
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SC translated from EMBL:U80251
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FT 1 34 
A/B domain [3].
FT 34 141 
DNA binding domain (DBD) [3].
FT 37 108 
SM00399; c4gold.
FT 37 112 
PS51030; NUCLEAR_REC_DBD_2.
FT 38 113 
PF00105; Zinc finger, C4 type (two domains).
FT 141 256 
Hinge [3].
FT 301 464 
SM00430; holi.
FT 304 489 
PF00104; Ligand-binding domain of nuclear hormon.
FT 342 390 
Ligand-binding domain [3].
FT 419 424 
Lipid binding domain [3].
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IN T08256 SRC-1A; human, Homo sapiens.
IN T08500 SRC3-xbb1; human, Homo sapiens.
IN T02483 TIF2; human, Homo sapiens.
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MX M01142 V$LRH1_Q5.
MX M02098 V$LRH1_Q5_01.
MX M07360 V$LRH1_Q6.
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BS R19282.
BS R21181.
BS R20844.
BS R20931.
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DR TRANSPATH: MO000058986.
DR EMBL: U80251; U80251.
DR UniProtKB: O00482-2;
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RN [1]; RE0035956.
RX PUBMED: 15143151.
RA Xu P. L., Liu Y. Q., Shan S. F., Kong Y. Y., Zhou Q., Li M., Ding J. P., Xie Y. H., Wang Y.
RT Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.
RL Mol. Endocrinol. 18:1887-1905 (2004).
RN [2]; RE0049388.
RX PUBMED: 15923626.
RA Chalkiadaki A., Talianidis I.
RT SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin.
RL Mol. Cell. Biol. 25:5095-5105 (2005).
RN [3]; RE0053152.
RX PUBMED: 15205472.
RA Qin J., Gao D. M., Jiang Q. F., Zhou Q., Kong Y. Y., Wang Y., Xie Y. H.
RT Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene.
RL Mol. Endocrinol. 18:2424-2439 (2004).
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