AC T08256
XX
ID T08256
XX
DT 09.11.2005 (created); ili.
DT 23.07.2010 (updated); jig.
CO Copyright (C), QIAGEN.
XX
FA SRC-1A
XX
SY NCOA-1; NCOA1; nuclear receptor coactivator 1; SRC-1; SRC-1alpha; steroid receptor coactivator-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002755 NCOA1; HGNC: NCOA1.
XX
CL C0010; bHLH; 1.2.5.3.1.1.
XX
SZ 1441 AA; 156.7 kDa (cDNA) (calc.).
XX
SQ MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
SQ SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
SQ DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
SQ VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
SQ SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
SQ QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
SQ IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
SQ QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
SQ ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
SQ LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
SQ SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
SQ TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
SQ VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
SQ MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
SQ TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
SQ QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
SQ VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
SQ MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
SQ AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
SQ GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
SQ RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
SQ PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
SQ MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
SQ ADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT
SQ E
XX
SC Swiss-Prot#Q15788-1
XX
FT 633 637 
NR-box motif (LXXLL) [2].
FT 633 783 
nuclear receptor interaction [3].
FT 690 694 
NR-box motif (LXXLL) [2].
FT 749 753 
NR-box motif (LXXLL) [2].
FT 974 1129 
CBP interaction [3].
FT 1435 1439 
NR-box motif (LXXLL) [18].
XX
FF residues 1107-1441 of SRC-1 have strong intrinsic HAT activity [1];
XX
IN T18749 Ahr-xbb2; human, Homo sapiens.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T00041 AR; mouse, Mus musculus.
IN T18820 BMAL1-isoform4; mouse, Mus musculus.
IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T23087 C2TA; Mammalia.
IN T08505 COUP-TF1; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T00333 GR; rat, Rattus norvegicus.
IN T00372 HNF-4alpha1; rat, Rattus norvegicus.
IN T08525 LRH1-isoform1; human, Homo sapiens.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T14193 NR1B1; Mammalia.
IN T25624 p/CAF; human, Homo sapiens.
IN T08321 p53-isoform1; human, Homo sapiens.
IN T00545 POU2F1; human, Homo sapiens.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T08580 STAT3-isoform1; human, Homo sapiens.
IN T08501 T3R-alpha; chick, Gallus gallus.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T01692 T3R-beta1; chick, Gallus gallus.
IN T01350 T3R-beta2; rat, Rattus norvegicus.
IN T01693 T3R-beta2; chick, Gallus gallus.
IN T14175 TBP; Mammalia.
XX
DR TRANSPATH: MO000056526.
DR EMBL: AJ000881;
DR EMBL: U90661;
DR UniProtKB: Q15788-1;
XX
RN [1]; RE0006142.
RX PUBMED: 9296499.
RA Spencer T. E., Jenster G., Burcin M. M., Allis C. D., Zhou J., Mizzen C. A., McKenna N. J., Onate S. A., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT Steroid receptor coactivator-1 is a histone acetyltransferase
RL Nature 389:194-198 (1997).
RN [2]; RE0006908.
RX PUBMED: 9430642.
RA Voegel J. J., Heine M. J., Tini M., Vivat V., Chambon P., Gronemeyer H.
RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
RL EMBO J. 17:507-519 (1998).
RN [3]; RE0022248.
RX PUBMED: 9744281.
RA Westin S., Kurokawa R., Nolte R. T., Wisely G. B., McInerney E. M., Rose D. W., Milburn M. V., Rosenfeld M. G., Glass C. K.
RT Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators.
RL Nature 395:199-202 (1998).
RN [4]; RE0029151.
RX PUBMED: 11773079.
RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O.
RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
RL J. Biol. Chem. 277:8004-11 (2002).
RN [5]; RE0042804.
RX PUBMED: 10454579.
RA Kim H. J., Yi J. Y., Sung H. S., Moore D. D., Jhun B. H., Lee Y. C., Lee J. W.
RT Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation
RL Mol. Cell. Biol. 19:6323-32 (1999).
RN [6]; RE0047189.
RX PUBMED: 15062576.
RA Dotzlaw H., Papaioannou M., Moehren U., Claessens F., Baniahmad A.
RT Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor
RL Mol. Cell. Endocrinol. 213:79-85 (2003).
RN [7]; RE0047427.
RX PUBMED: 9556555.
RA Na S. Y., Lee S. K., Han S. J., Choi H. S., Im S. Y., Lee J. W.
RT Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations.
RL J. Biol. Chem. 273:10831-10834 (1998).
RN [8]; RE0047657.
RX PUBMED: 11435616.
RA Yang Z., Privalsky M. L.
RT Isoform-specific transcriptional regulation by thyroid hormone receptors: hormone-independent activation operates through a steroid receptor mode of co-activator interaction.
RL Mol. Endocrinol. 15:1170-1185 (2001).
RN [9]; RE0047851.
RX PUBMED: 10847592.
RA Lee S. K., Na S. Y., Jung S. Y., Choi J. E., Jhun B. H., Cheong J., Meltzer P. S., Lee Y. C., Lee J. W.
RT Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
RL Mol. Endocrinol. 14:915-925 (2000).
RN [10]; RE0047900.
RX PUBMED: 15641800.
RA Watt K., Jess T. J., Kelly S. M., Price N. C., McEwan I. J.
RT Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions.
RL Biochemistry 44:734-743 (2005).
RN [11]; RE0048011.
RX PUBMED: 10551785.
RA Lee S. K., Kim H. J., Kim J. W., Lee J. W.
RT Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.
RL Mol. Endocrinol. 13:1924-1933 (1999).
RN [12]; RE0048970.
RX PUBMED: 16645037.
RA Tian H., Mahajan M. A., Wong C. T., Habeos I., Samuels H. H.
RT The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.
RL Mol. Endocrinol. 20:2036-2051 (2006).
RN [13]; RE0049341.
RX PUBMED: 10971655.
RA Takahata S., Ozaki T., Mimura J., Kikuchi Y., Sogawa K., Fujii-Kuriyama Y.
RT Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3.
RL Genes Cells 5:739-747 (2000).
RN [14]; RE0050336.
RX PUBMED: 17587566.
RA Meyer R., Wolf S. S., Obendorf M.
RT PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
RL J. Steroid Biochem. Mol. Biol. 107:1-14 (2007).
RN [15]; RE0051638.
RX PUBMED: 10490591.
RA Sladek F. M., Ruse MD J. r., Nepomuceno L., Huang S. M., Stallcup M. R.
RT Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.
RL Mol. Cell. Biol. 19:6509-6522 (1999).
RN [16]; RE0051855.
RX PUBMED: 10809746.
RA Chen S., Cui J., Nakamura K., Ribeiro R. C., West B. L., Gardner D. G.
RT Coactivator-vitamin D receptor interactions mediate inhibition of the atrial natriuretic peptide promoter.
RL J. Biol. Chem. 275:15039-15048 (2000).
RN [17]; RE0052234.
RX PUBMED: 10652338.
RA Sugiyama T., Wang J. C., Scott D. K., Granner D. K.
RT Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.
RL J. Biol. Chem. 275:3446-3454 (2000).
RN [18]; RE0035978.
RX PUBMED: 10454563.
RA Ma H., Hong H., Huang S. M., Irvine R. A., Webb P., Kushner P. J., Coetzee G. A., Stallcup M. R.
RT Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins.
RL Mol. Cell. Biol. 19:6164-6173 (1999).
XX
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