TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T14193 XX ID T14193 XX DT 10.03.2005 (created); nvo. DT 11.12.2014 (updated); asv. CO Copyright (C), QIAGEN. XX FA NR1B1 XX SY NR1B1; RARa; retinoic acid receptor alpha. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T05777 ASC-2-isoform1; mouse, Mus musculus. IN T23082 ATF-4; Mammalia. IN T09446 c-Jun; Mammalia. IN T14435 c-Myc; Mammalia. IN T10260 CLOCK; human, Homo sapiens. IN T18364 Clock; Mammalia. IN T25698 DRIP205-isoform4; mouse, Mus musculus. IN T08300 ER-alpha-L; human, Homo sapiens. IN T09637 ER-alpha; Mammalia. IN T17427 ER-beta; mouse, Mus musculus. IN T11196 MOP4; human, Homo sapiens. IN T04687 NCOR1; human, Homo sapiens. IN T11027 NFATc3; Mammalia. IN T10625 Nur77; Mammalia. IN T23091 p300; Mammalia. IN T09964 RXR-alpha; Mammalia. IN T04689 SMRT; human, Homo sapiens. IN T21552 SRC-1; Mammalia. IN T08256 SRC-1A; human, Homo sapiens. IN T14458 STAT3; Mammalia. IN T16578 TGIF; Mammalia. XX MX M00965 V$DR4_Q2. MX M02110 V$NR1B1_Q6. MX M07280 V$NR1NR2_Q3. MX M00963 V$T3R_Q6. XX BS R23650. BS R10085. BS R72738. BS R27490. BS R03962. BS R27394. XX DR TRANSPATH: MO000046434. XX RN [1]; RE0001742. RX PUBMED: 1646397. RA Rottman J. N., Widom R. L., Nadal-Ginard B., Mahdavi V., Karathanasis S. K. RT A retinoic acid-responsive element in the apolipoprotein A1 gene distinguishes between two different retinoic acid response pathways RL Mol. Cell. Biol. 11:3814-3820 (1991). RN [2]; RE0002566. RX PUBMED: 1648728. RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone L. J., Bolado J., Verma I. M., Evans R. M. RT Retinoic acid is a negative regulator of AP-1-responsive genes RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991). RN [3]; RE0018271. RX PUBMED: 10617585. RA Naltner A., Ghaffari M., Whitsett J. A., Yan C. RT Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent. RL J. Biol. Chem. 275:56-62 (2000). RN [4]; RE0022447. RX PUBMED: 11274148. RA Yan C., Naltner A., Conkright J., Ghaffari M. RT Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells. RL J. Biol. Chem. 276:21686-21691 (2001). RN [5]; RE0026435. RX PUBMED: 10788465. RA Zhu Y., Kan L., Qi C., Kanwar Y. S., Yeldandi A. V., Rao M. S., Reddy J. K. RT Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. RL J. Biol. Chem. 275:13510-6 (2000). RN [6]; RE0029603. RX PUBMED: 11971969. RA Shao W., Halachmi S., Brown M. RT ERAP140, a conserved tissue-specific nuclear receptor coactivator. RL Mol. Cell. Biol. 22:3358-72 (2002). RN [7]; RE0031471. RX PUBMED: 14993281. RA Wang J., Yen A. RT A novel retinoic acid-responsive element regulates retinoic acid-induced BLR1 expression. RL Mol. Cell. Biol. 24:2423-43 (2004). RN [8]; RE0031767. RX PUBMED: 12885766. RA Brown K., Chen Y., Underhill T. M., Mymryk J. S., Torchia J. RT The coactivator p/CIP/SRC-3 facilitates retinoic acid receptor signaling via recruitment of GCN5. RL J. Biol. Chem. 278:39402-12 (2003). RN [9]; RE0032103. RX PUBMED: 15044588. RA Yang L., Lian X., Cowen A., Xu H., Du H., Yan C. RT Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-alpha in regulation of the surfactant protein B gene in the lung. RL Mol. Endocrinol. 18:1520-32 (2004). RN [10]; RE0037650. RX PUBMED: 12039952. RA Qi C., Chang J., Zhu Y., Yeldandi A. V., Rao S. M., Zhu Y. J. RT Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha RL J. Biol. Chem. 277:28624-30 (2002). RN [11]; RE0037998. RX PUBMED: 12393001. RA van Veen T. A., van Rijen H. V., Wiegerinck R. F., Opthof T., Colbert M. C., Clement S., de Bakker J. M., Jongsma H. J. RT Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling RL J. Mol. Cell. Cardiol. 34:1411-23 (2002). RN [12]; RE0037999. RX PUBMED: 12588987. RA Song L. N., Herrell R., Byers S., Shah S., Wilson E. M., Gelmann E. P. RT Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription RL Mol. Cell. Biol. 23:1674-87 (2003). RN [13]; RE0038487. RX PUBMED: 10865976. RA Tenno T., Botling J., Oberg F., Jossan S., Nilsson K., Siegbahn A. RT The role of RAR and RXR activation in retinoid-induced tissue factor suppression RL Leukemia 14:1105-11 (2000). RN [14]; RE0038825. RX PUBMED: 14976209. RA Pitha-Rowe I., Hassel B. A., Dmitrovsky E. RT Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia RL J. Biol. Chem. 279:18178-87 (2004). RN [15]; RE0039096. RX PUBMED: 10637480. RA So C. W., Dong S., So C. K., Cheng G. X., Huang Q. H., Chen S. J., Chan L. C. RT The impact of differential binding of wild-type RARalpha, PML-, PLZF- and NPM-RARalpha fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia RL Leukemia 14:77-83 (2000). RN [16]; RE0039762. RX PUBMED: 11566180. RA Kohroki J., Fujita S., Itoh N., Yamada Y., Imai H., Yumoto N., Nakanishi T., Tanaka K. RT ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells RL FEBS Lett. 505:223-8 (2001). RN [17]; RE0039828. RX PUBMED: 10772826. RA Kang H. J., Song M. R., Lee S. K., Shin E. C., Choi Y. H., Kim S. J., Lee J. W., Lee M. O. RT Retinoic acid and its receptors repress the expression and transactivation functions of Nur77: a possible mechanism for the inhibition of apoptosis by retinoic acid RL Exp. Cell Res. 256:545-54 (2000). RN [18]; RE0039923. RX PUBMED: 10640450. RA Ohata M., Yamauchi M., Takeda K., Toda G., Kamimura S., Motomura K., Xiong S., Tsukamoto H. RT RAR and RXR expression by Kupffer cells RL Exp. Mol. Pathol. 68:13-20 (2000). RN [19]; RE0039935. RX PUBMED: 11435607. RA Cohen R. N., Brzostek S., Kim B., Chorev M., Wondisford F. E., Hollenberg A. N. RT The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains RL Mol. Endocrinol. 15:1049-61 (2001). RN [20]; RE0039937. RX PUBMED: 9531570. RA Guidez F., Ivins S., Zhu J., Soderstrom M., Waxman S., Zelent A. RT Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia RL Blood 91:2634-42 (1998). RN [21]; RE0039941. RX PUBMED: 11682061. RA Bastie J. N., Despouy G., Balitrand N., Rochette-Egly C., Chomienne C., Delva L. RT The novel co-activator CRABPII binds to RARalpha and RXRalpha via two nuclear receptor interacting domains and does not require the AF-2 'core' RL FEBS Lett. 507:67-73 (2001). RN [22]; RE0039944. RX PUBMED: 10629053. RA Lin B., Chen G. Q., Xiao D., Kolluri S. K., Cao X., Su H., Zhang X. K. RT Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells RL Mol. Cell. Biol. 20:957-70 (2000). RN [23]; RE0039945. RX PUBMED: 9841885. RA Song M. R., Lee S. K., Seo Y. W., Choi H. S., Lee J. W., Lee M. O. RT Differential modulation of transcriptional activity of oestrogen receptors by direct protein-protein interactions with retinoid receptors RL Biochem. J. 336:711-7 (1998). RN [24]; RE0039979. RX PUBMED: 11929748. RA Dong S., Tweardy D. J. RT Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways RL Blood 99:2637-46 (2002). RN [25]; RE0039985. RX PUBMED: 10082574. RA Mouchon A., Delmotte M. H., Formstecher P., Lefebvre P. RT Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA RL Mol. Cell. Biol. 19:3073-85 (1999). RN [26]; RE0039987. RX PUBMED: 14559998. RA Watashi K., Hijikata M., Tagawa A., Doi T., Marusawa H., Shimotohno K. RT Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus RL Mol. Cell. Biol. 23:7498-509 (2003). RN [27]; RE0039994. RX PUBMED: 9469826. RA Schmidt S., Baniahmad A., Eggert M., Schneider S., Renkawitz. RT Multiple receptor interaction domains of GRIP1 function in synergy RL Nucleic Acids Res. 26:1191-7 (1998). RN [28]; RE0039997. RX PUBMED: 10722729. RA Denson L. A., Auld K. L., Schiek D. S., McClure M. H., Mangelsdorf D. J., Karpen S. J. RT Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation RL J. Biol. Chem. 275:8835-43 (2000). RN [29]; RE0040017. RX PUBMED: 10995752. RA Elizondo G., Corchero J., Sterneck E., Gonzalez F. J. RT Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/Enhancer-binding protein beta RL J. Biol. Chem. 275:39747-53 (2000). RN [30]; RE0040031. RX PUBMED: 12943985. RA Franco P. J., Li G., Wei L. N. RT Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase RL Mol. Cell. Endocrinol. 206:1-12 (2003). RN [31]; RE0040099. RX PUBMED: 10753851. RA Redner R. L., Chen J. D., Rush E. A., Li H., Pollock S. L. RT The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties RL Blood 95:2683-90 (2000). RN [32]; RE0040100. RX PUBMED: 9892191. RA Zhu W. Y., Jones C. S., Amin S., Matsukuma K., Haque M., Vuligonda V., Chandraratna R. A., De Luca L. M. RT Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells RL Cancer Res. 59:85-90 (1999). RN [33]; RE0040618. RX PUBMED: 9325263. RA Zhu Y., Qi C., Jain S., Rao M. S., Reddy J. K. RT Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor RL J. Biol. Chem. 272:25500-6 (1997). RN [34]; RE0041568. RX PUBMED: 10484292. RA Shen X. Q., Bubulya A., Zhou X. F., Khazak V., Golemis E. A., Shemshedini L. RT Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription RL Endocrine 10:281-9 (1999). RN [35]; RE0042804. RX PUBMED: 10454579. RA Kim H. J., Yi J. Y., Sung H. S., Moore D. D., Jhun B. H., Lee Y. C., Lee J. W. RT Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation RL Mol. Cell. Biol. 19:6323-32 (1999). RN [36]; RE0046545. RX PUBMED: 11358960. RA Chan S. W., Hong W. RT Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription RL J. Biol. Chem. 276:28402-12 (2001). RN [37]; RE0047600. RX PUBMED: 9717844. RA Lee S. K., Choi H. S., Song M. R., Lee M. O., Lee J. W. RT Estrogen receptor, a common interaction partner for a subset of nuclear receptors. RL Mol. Endocrinol. 12:1184-1192 (1998). RN [38]; RE0047935. RX PUBMED: 9765306. RA Wong C. W., Privalsky M. L. RT Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. RL J. Biol. Chem. 273:27695-27702 (1998). RN [39]; RE0048488. RX PUBMED: 15691842. RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N. RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. RL J. Biol. Chem. 280:13600-13605 (2005). RN [40]; RE0049512. RX PUBMED: 16428452. RA Bartholin L., Powers S. E., Melhuish T. A., Lasse S., Weinstein M., Wotton D. RT TGIF inhibits retinoid signaling. RL Mol. Cell. Biol. 26:990-1001 (2006). RN [41]; RE0053233. RX PUBMED: 10993727. RA Bogan A. A., Dallas-Yang Q., Ruse MD J. r., Maeda Y., Jiang G., Nepomuceno L., Scanlan T. S., Cohen F. E., Sladek F. M. RT Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. RL J. Mol. Biol. 302:831-851 (2000). RN [42]; RE0070445. RX PUBMED: 11970916. RA Chang W. H., Reddy S. P., Di Y. P., Yoneda K., Harper R., Wu R. RT Regulation of thioredoxin gene expression by vitamin A in human airway epithelial cells. RL Am. J. Respir. Cell Mol. Biol. 26:627-635 (2002). XX //