AC T05777
XX
ID T05777
XX
DT 04.12.2003 (created); oke.
DT 17.08.2007 (updated); bch.
CO Copyright (C), QIAGEN.
XX
FA ASC-2-isoform1
XX
SY AIB3; ASC-2; ASC2; NCOA6; Ncoa7; NRC; nuclear receptor coactivator 6; nuclear receptor-activating protein 250; peroxisome proliferator-activated receptor interacting protein; PPAR interacting protein PRIP; PRIP; RAP250; thyroid hormone receptor binding protein.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009067 Ncoa6.
XX
SZ 2067 AA; 219.6 kDa (cDNA) (calc.).
XX
SQ MVLDDLPNFEDIYTSLCSSTMGDSEVEFDSGLEDDDTKGDSILEDSTIFVAFKGNIDDKD
SQ FKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLWILAQSNNQQLR
SQ DLGILSVQIEGEGAINLALGQNRSQDVRMNGPVASGNSVRMEAGFPMASGPGLIRMTSPA
SQ AVMTPQGGNMSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLPPAH
SQ HSMQPVPVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQTRPLQQHQ
SQ QQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTTNQGWKKAPLPSPMQAQ
SQ LQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKGLQGGPSRVPT
SQ PLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLSQGFQQPVSSPGR
SQ NPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPST
SQ TAATPGNSGALQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNINNQQA
SQ GSSGVPQVTLGNMQGQPQQGPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLM
SQ PQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQI
SQ MTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNS
SQ PSQVMGIQGQVLRPPGPSPHMAQQHTDPVTTANNDVNLSQMMPDVSMQQASMVPPHVQSM
SQ QGNSASGSHFSGHGVSFNAPFGGAPNGSQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDIS
SQ AGHFGVNNKQNNTNANKPKKKKPPRKKKNCHQDLNTPDNRPTGLEEVDQQSLPGEQGINL
SQ DTTGPKLPDFSNRPPGYPTQPVEQRPLPQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPP
SQ PPSQPQSQQQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRMPVQQSGNVP
SQ VMVGLQGPASVPPSPDKQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPEASG
SQ SEVPSVAGGPNNMPSHLVVSQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHF
SQ PNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQIN
SQ IPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVVVNSGKQS
SQ NPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQNMELPRNVLV
SQ GPTPLANPPLPGSFPNNTGLNPQNPTVPVPAMGTVLEDNKESVNIPQDSDCQNAQGRKEQ
SQ VNTELKVVPTQEAKMAVPEDQSKKDGQPLDPNKLPSVEENKNLMSPAMREAPTSLSQLLD
SQ NSGAPNVTIKPPGLTDLEVTPPVVSGEDLRKASVIPTLQDPPSKEPSTSLSSPHSSEPCS
SQ TLARSELSEVSSNAAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALP
SQ THLQSALMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPST
SQ IPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAPNIQTGRPLVLSSR
SQ ATPVQLPSPPCTSSPVVAPNPSVQQVKELNPDEASPQTNTSADQSTLPPSQPTTVVSSLL
SQ TNSPGSSANRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGPGL
SQ EITTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMAPSSTSTGPILPGGALPTSVRSI
SQ VTTLVPSELISTAPTTKGNHGGVTSEPLAGGLVEEKVGSHPELLPSIAPSQNLAPKETPA
SQ TALQGSVARPELEANAAIASGQSCEPKEIVEKSKTLTSRRNSRTEEPTMASESVENGHRK
SQ RSSRPASASSSTKDITGAVQSKRRKSK
XX
SC translated from EMBL #AF216186
XX
SF contains two nuclear receptor interaction domains of LXXLL-type;
XX
FF co-activator for PPAR, LXR, and several other transcription factors;
FF is an important regulator of the novo lipid synthesis [1];
XX
IN T09602 ER; Mammalia.
IN T14193 NR1B1; Mammalia.
IN T05347 PPARgamma; mouse, Mus musculus.
IN T05351 PPARgamma; human, Homo sapiens.
IN T09964 RXR-alpha; Mammalia.
IN T15588 T3R-beta1; Mammalia.
XX
DR TRANSPATH: MO000038200.
DR EMBL: AF216186;
DR UniProtKB: Q9JL19;
XX
RN [1]; RE0023608.
RX PUBMED: 12724417.
RA Kim S. W., Park K., Kwak E., Choi E., Lee S., Ham J., Kang H., Kim J. M., Hwang S. Y., Kong Y. Y., Lee K., Lee J. W.
RT Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
RL Mol. Cell. Biol. 23:3583-3592 (2003).
RN [2]; RE0026435.
RX PUBMED: 10788465.
RA Zhu Y., Kan L., Qi C., Kanwar Y. S., Yeldandi A. V., Rao M. S., Reddy J. K.
RT Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.
RL J. Biol. Chem. 275:13510-6 (2000).
XX
//