AC T04689
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ID T04689
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DT 03.09.2001 (created); mas.
DT 20.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA SMRT
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SY N-CoR 2; N-COR2; nuclear receptor co-repressor 2; silencing mediator of retinoic acid and thyroid hormone; silencing mediator of retinoid and thyroid hormone receptors; SMRT; SMRTE; T3 receptor-associating factor; TRAC.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002795 NCOR2; HGNC: NCOR2.
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CL C0022; trp; 3.5.1.2.2.
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SF contains separate domains for interaction with nuclear receptors and repression function [5];
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FF involved in mediation of transcriptional repressive effect of (unliganded) nuclear receptors (direct binding to nuclear receptors) [1];
FF interacts also with and is corepressor for other classes of transcription factors (than nuclear receptors) like AP-1, NFkappaB and SRF [3];
FF recruitment of histone deacetylase complexes which is important for transcriptional repression [1];
FF binds to RAR-alpha and TR and binding is stronger in the absence of ligands for these nuclear receptors [2];
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IN T00018 AhR; mouse, Mus musculus.
IN T00040 AR; human, Homo sapiens.
IN T15601 AR; Mammalia.
IN T01346 arnt-isoform1; human, Homo sapiens.
IN T21924 BCL-11A; human, Homo sapiens.
IN T09129 BCL-6-isoform1; human, Homo sapiens.
IN T16043 BCL-6; Mammalia.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T05687 CAR; mouse, Mus musculus.
IN T09428 COUP-TF1; mouse, Mus musculus.
IN T09429 COUP-TF2; mouse, Mus musculus.
IN T01546 E2F-4; human, Homo sapiens.
IN T09632 FXR; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T04110 HDAC3; human, Homo sapiens.
IN T08522 HDAC4-isoform1; human, Homo sapiens.
IN T06042 HDAC4; human, Homo sapiens.
IN T02752 LXR-alpha; human, Homo sapiens.
IN T04453 LXR-beta; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T08888 LXRalpha-isoform1; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T14193 NR1B1; Mammalia.
IN T00721 NR1B2; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T05347 PPARgamma; mouse, Mus musculus.
IN T05351 PPARgamma; human, Homo sapiens.
IN T09963 PPARgamma; Mammalia.
IN T01661 PR A; human, Homo sapiens.
IN T04617 PXR-isoform1A; human, Homo sapiens.
IN T08235 PXR; mouse, Mus musculus.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T10352 Rev-ErbAalpha; Mammalia.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T04807 RXR-gamma; human, Homo sapiens.
IN T04597 SKIP; human, Homo sapiens.
IN T08326 Sp1; Mammalia.
IN T17263 STAT3{pY}; human, Homo sapiens.
IN T01152 T3R-alpha1; human, Homo sapiens.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T16580 T3R-beta; Mammalia.
IN T28757 TBLR1; human, Homo sapiens.
IN T19396 Zbtb5; human, Homo sapiens.
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DR TRANSPATH: MO000031039.
DR UniProtKB: Q9Y618;
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RN [1]; RE0005939.
RX PUBMED: 9150137.
RA Nagy L., Kao H.-Y., Chakravarti D., Lin R. J., Hassig C. A., Ayer D. E., Schreiber S. L., Evans R. M.
RT Nuclear receptor repression mediated by a complex containing SMRT, mSin3a, and histone deacetylase
RL Cell 89:373-380 (1997).
RN [2]; RE0010823.
RX PUBMED: 7566127.
RA Chen J. D., Evans R. M.
RT A transcriptional co-repressor that interacts with nuclear hormone receptors
RL Nature 377:454-457 (1995).
RN [3]; RE0015392.
RX PUBMED: 10777532.
RA Lee S. K., Kim J. H., Lee Y. C., Cheong J., Lee J. W.
RT Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor
RL J. Biol. Chem. 275:12470-12474 (2000).
RN [4]; RE0015982.
RX PUBMED: 9092799.
RA Yoh S. M., Chatterjee V. K., Privalsky M. L.
RT Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.
RL Mol. Endocrinol. 11:470-480 (1997).
RN [5]; RE0016802.
RX PUBMED: 10617570.
RA Nagy L., Kao H. Y., Love J. D., Li C., Banayo E., Gooch J. T., Krishna V., Chatterjee K., Evans R. M., Schwabe J. W.
RT Mechanism of corepressor binding and release from nuclear hormone receptors
RL Genes Dev. 13:3209-3216 (1999).
RN [6]; RE0026518.
RX PUBMED: 10809664.
RA Guenther M. G., Lane W. S., Fischle W., Verdin E., Lazar M. A., Shiekhattar R.
RT A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
RL Genes Dev. 14:1048-57 (2000).
RN [7]; RE0026599.
RX PUBMED: 10898795.
RA Huynh K. D., Fischle W., Verdin E., Bardwell V. J.
RT BCoR, a novel corepressor involved in BCL-6 repression.
RL Genes Dev. 14:1810-23 (2000).
RN [8]; RE0027552.
RX PUBMED: 10640275.
RA Huang E. Y., Zhang J., Miska E. A., Guenther M. G., Kouzarides T., Lazar M. A.
RT Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
RL Genes Dev. 14:45-54 (2000).
RN [9]; RE0029293.
RX PUBMED: 11804585.
RA Fischle W., Dequiedt F., Hendzel M. J., Guenther M. G., Lazar M. A., Voelter W., Verdin E.
RT Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
RL Mol. Cell 9:45-57 (2002).
RN [10]; RE0032617.
RX PUBMED: 14975242.
RA Wang L. H., Yang X. Y., Zhang X., Huang J., Hou J., Li J., Xiong H., Mihalic K., Zhu H., Xiao W., Farrar W. L.
RT Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
RL Immunity 20:205-18 (2004).
RN [11]; RE0036641.
RX PUBMED: 12628926.
RA Yoon H. G., Chan D. W., Huang Z. Q., Li J., Fondell J. D., Qin J., Wong J.
RT Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
RL EMBO J. 22:1336-1346 (2003).
RN [12]; RE0038037.
RX PUBMED: 11739383.
RA Fischer D. D., Cai R., Bhatia U., Asselbergs F. A., Song C., Terry R., Trogani N., Widmer R., Atadja P., Cohen D.
RT Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10
RL J. Biol. Chem. 277:6656-66 (2002).
RN [13]; RE0038083.
RX PUBMED: 11466315.
RA Fischle W., Dequiedt F., Fillion M., Hendzel M. J., Voelter W., Verdin E.
RT Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
RL J. Biol. Chem. 276:35826-35 (2001).
RN [14]; RE0039595.
RX PUBMED: 12077342.
RA Dellaire G., Makarov E. M., Cowger J. J., Longman D., Sutherland H. G., Luhrmann R., Torchia J., Bickmore W. A.
RT Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes
RL Mol. Cell. Biol. 22:5141-56 (2002).
RN [15]; RE0048154.
RX PUBMED: 10984530.
RA Downes M., Ordentlich P., Kao H. Y., Alvarez J. G., Evans R. M.
RT Identification of a nuclear domain with deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 97:10330-10335 (2000).
RN [16]; RE0048365.
RX PUBMED: 16893456.
RA Zhang X. M., Chang Q., Zeng L., Gu J., Brown S., Basch R. S.
RT TBLR1 regulates the expression of nuclear hormone receptor co-repressors.
RL BMC Cell Biol. 7:31 (2006).
RN [17]; RE0048421.
RX PUBMED: 16219912.
RA Johnson D. R., Li C. W., Chen L. Y., Ghosh J. C., Chen J. D.
RT Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).
RL Mol. Pharmacol. 69:99-108 (2006).
RN [18]; RE0048484.
RX PUBMED: 10860984.
RA Wen Y. D., Perissi V., Staszewski L. M., Yang W. M., Krones A., Glass C. K., Rosenfeld M. G., Seto E.
RT The histone deacetylase-3 complex contains nuclear receptor corepressors.
RL Proc. Natl. Acad. Sci. USA 97:7202-7207 (2000).
RN [19]; RE0048488.
RX PUBMED: 15691842.
RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N.
RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
RL J. Biol. Chem. 280:13600-13605 (2005).
RN [20]; RE0048529.
RX PUBMED: 14527417.
RA Yoon H. G., Chan D. W., Reynolds A. B., Qin J., Wong J.
RT N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.
RL Mol. Cell 12:723-734 (2003).
RN [21]; RE0048530.
RX PUBMED: 11865059.
RA Melnick A., Carlile G., Ahmad K. F., Kiang C. L., Corcoran C., Bardwell V., Prive G. G., Licht J. D.
RT Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.
RL Mol. Cell. Biol. 22:1804-1818 (2002).
RN [22]; RE0048796.
RX PUBMED: 12897148.
RA Wagner B. L., Valledor A. F., Shao G., Daige C. L., Bischoff E. D., Petrowski M., Jepsen K., Baek S. H., Heyman R. A., Rosenfeld M. G., Schulman I. G., Glass C. K.
RT Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
RL Mol. Cell. Biol. 23:5780-5789 (2003).
RN [23]; RE0048810.
RX PUBMED: 17000644.
RA Vertegaal A. C., Andersen J. S., Ogg S. C., Hay R. T., Mann M., Lamond A. I.
RT Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.
RL Mol. Cell. Proteomics 5:2298-2310 (2006).
RN [24]; RE0048913.
RX PUBMED: 15878880.
RA Lee J. A., Suh D. C., Kang J. E., Kim M. H., Park H., Lee M. N., Kim J. M., Jeon B. N., Roh H. E., Yu M. Y., Choi K. Y., Kim K. Y., Hur M. W.
RT Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.
RL J. Biol. Chem. 280:28061-28071 (2005).
RN [25]; RE0048942.
RX PUBMED: 16373395.
RA Yoon H. G., Wong J.
RT The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.
RL Mol. Endocrinol. 20:1048-1060 (2006).
RN [26]; RE0051310.
RX PUBMED: 16354658.
RA Albers M., Blume B., Schlueter T., Wright M. B., Kober I., Kremoser C., Deuschle U., Koegl M.
RT A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
RL J. Biol. Chem. 281:4920-4930 (2006).
RN [27]; RE0051974.
RX PUBMED: 15494311.
RA Hoberg J. E., Yeung F., Mayo M. W.
RT SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
RL Mol. Cell 16:245-255 (2004).
RN [28]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [29]; RE0067377.
RX PUBMED: 19955185.
RA Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
RT SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR.
RL J. Biol. Chem. 285:5983-5992 (2010).
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