AC T17263
XX
ID T17263
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DT 15.01.2003 (created); spi.
DT 11.08.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA STAT3{pY}
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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EX blood,monocyte,Circulatory System & Hematopoietic System,adult; detectable; subcellular extraction of proteins; [1].
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IN T00992 Hsp90; human, Homo sapiens.
IN T05351 PPARgamma; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
XX
BS R25857.
BS R29652.
BS R29880.
BS R29879.
BS R04223.
BS R69141.
BS R00163.
XX
DR TRANSPATH: MO000034207.
XX
RN [1]; RE0022301.
RX PUBMED: 12223527.
RA Roy B., Bhattacharjee A., Xu B., Ford D., Maizel A. L., Cathcart M. K.
RT IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats.
RL J. Leukoc. Biol. 72:580-589 (2002).
RN [2]; RE0027935.
RX PUBMED: 11285233.
RA Plun-Favreau H., Elson G., Chabbert M., Froger J., deLapeyriere O., Lelievre E., Guillet C., Hermann J., Gauchat J. F., Gascan H., Chevalier S.
RT The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.
RL EMBO J. 20:1692-703 (2001).
RN [3]; RE0028499.
RX PUBMED: 9030543.
RA Robledo O., Fourcin M., Chevalier S., Guillet C., Auguste P., Pouplard-Barthelaix A., Pennica D., Gascan H.
RT Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component.
RL J. Biol. Chem. 272:4855-63 (1997).
RN [4]; RE0032617.
RX PUBMED: 14975242.
RA Wang L. H., Yang X. Y., Zhang X., Huang J., Hou J., Li J., Xiong H., Mihalic K., Zhu H., Xiao W., Farrar W. L.
RT Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
RL Immunity 20:205-18 (2004).
RN [5]; RE0032743.
RX PUBMED: 7722452.
RA Jacobson N. G., Szabo S. J., Weber-Nordt R. M., Zhong Z., Schreiber R. D., Darnell J. E. Jr, Murphy K. M.
RT Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
RL J. Exp. Med. 181:1755-62 (1995).
RN [6]; RE0032828.
RX PUBMED: 11801527.
RA Miscia S., Marchisio M., Grilli A., Di Valerio V., Centurione L., Sabatino G., Garaci F., Zauli G., Bonvini E., Di Baldassarre A.
RT Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells.
RL Cell Growth Differ. 13:13-8 (2002).
RN [7]; RE0041903.
RX PUBMED: 9422769.
RA Al-Shami A., Mahanna W., Naccache P. H.
RT Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b
RL J. Biol. Chem. 273:1058-63 (1998).
RN [8]; RE0043317.
RX PUBMED: 12023369.
RA Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K. P., Vega F., To W., Wagner J., O'Farrell A. M., McClanahan T., Zurawski S., Hannum C., Gorman D., Rennick D. M., Kastelein R. A., de Waal Malefyt R., Moore K. W.
RT A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
RL J. Immunol. 168:5699-708 (2002).
RN [9]; RE0048007.
RX PUBMED: 12235142.
RA Shah M., Patel K., Fried V. A., Sehgal P. B.
RT Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever.
RL J. Biol. Chem. 277:45662-45669 (2002).
RN [10]; RE0048132.
RX PUBMED: 9845531.
RA Ozaki K., Oda A., Wakao H., Rhodes J., Druker B. J., Ishida A., Wakui M., Okamoto S., Morita K., Handa M., Komatsu N., Ohashi H., Miyajima A., Ikeda Y.
RT Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets.
RL Blood 92:4652-4662 (1998).
RN [11]; RE0049315.
RX PUBMED: 11322786.
RA Matsuda T., Junicho A., Yamamoto T., Kishi H., Korkmaz K., Saatcioglu F., Fuse H., Muraguchi A.
RT Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells.
RL Biochem. Biophys. Res. Commun. 283:179-187 (2001).
RN [12]; RE0049337.
RX PUBMED: 14993658.
RA MacDonald A., Crowder K., Street A., McCormick C., Harris M.
RT The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
RL J. Gen. Virol. 85:721-729 (2004).
RN [13]; RE0051288.
RX PUBMED: 9038364.
RA Nakashima K., Narazaki M., Taga T.
RT Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130.
RL FEBS Lett. 403:79-82 (1997).
RN [14]; RE0052747.
RX PUBMED: 16782820.
RA Rousseau F., Gauchat J. F., McLeod J. G., Chevalier S., Guillet C., Guilhot F., Cognet I., Froger J., Hahn A. F., Knappskog P. M., Gascan H., Boman H.
RT Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.
RL Proc. Natl. Acad. Sci. USA 103:10068-10073 (2006).
RN [15]; RE0053419.
RX PUBMED: 14551204.
RA Sandberg E. M., Ma X., VonDerLinden D., Godeny M. D., Sayeski P. P.
RT Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1.
RL J. Biol. Chem. 279:1956-1967 (2004).
RN [16]; RE0060125.
RX PUBMED: 15905523.
RA Mattioli B., Straface E., Quaranta M. G., Giordani L., Viora M.
RT Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming.
RL J. Immunol. 174:6820-6828 (2005).
RN [17]; RE0062522.
RX PUBMED: 16713974.
RA Hu X., Paik P. K., Chen J., Yarilina A., Kockeritz L., Lu T. T., Woodgett J. R., Ivashkiv L. B.
RT IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
RL Immunity 24:563-574 (2006).
RN [18]; RE0063840.
RX PUBMED: 17567983.
RA Chalaris A., Rabe B., Paliga K., Lange H., Laskay T., Fielding C. A., Jones S. A., Rose-John S., Scheller J.
RT Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
RL Blood 110:1748-1755 (2007).
RN [19]; RE0064287.
RX PUBMED: 16670329.
RA Yu Y., Nagai S., Wu H., Neish A. S., Koyasu S., Gewirtz A. T.
RT TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression.
RL J. Immunol. 176:6194-6201 (2006).
RN [20]; RE0065662.
RX PUBMED: 16000408.
RA Du Z., Shen Y., Yang W., Mecklenbrauker I., Neel B. G., Ivashkiv L. B.
RT Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
RL Proc. Natl. Acad. Sci. USA 102:10267-10272 (2005).
RN [21]; RE0066013.
RX PUBMED: 18698163.
RA Maher S. G., Sheikh F., Scarzello A. J., Romero-Weaver A. L., Baker D. P., Donnelly R. P., Gamero A. M.
RT IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity.
RL Cancer Biol. Ther. 7:1109-1115 (2008).
RN [22]; RE0066165.
RX PUBMED: 17627610.
RA Marijanovic Z., Ragimbeau J., Van der Heyden J., Uze G., Pellegrini S.
RT Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.
RL Biochem. J. 407:141-151 (2007).
RN [23]; RE0066463.
RX PUBMED: 12789268.
RA Walters D. K., French J. D., Arendt B. K., Jelinek D. F.
RT Atypical expression of ErbB3 in myeloma cells: cross-talk between ErbB3 and the interferon-alpha signaling complex.
RL Oncogene 22:3598-3607 (2003).
RN [24]; RE0067228.
RX PUBMED: 12643274.
RA Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., Kallen K. J.
RT Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
RL J. Biol. Chem. 278:9528-9535 (2003).
RN [25]; RE0067528.
RX PUBMED: 15051883.
RA Derouet D., Rousseau F., Alfonsi F., Froger J., Hermann J., Barbier F., Perret D., Diveu C., Guillet C., Preisser L., Dumont A., Barbado M., Morel A., deLapeyriere O., Gascan H., Chevalier S.
RT Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
RL Proc. Natl. Acad. Sci. USA 101:4827-4832 (2004).
RN [26]; RE0068270.
RX PUBMED: 15677447.
RA Novotny-Diermayr V., Lin B., Gu L., Cao X.
RT Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.
RL J. Biol. Chem. 280:12747-12757 (2005).
RN [27]; RE0068847.
RX PUBMED: 15850793.
RA Brand S., Zitzmann K., Dambacher J., Beigel F., Olszak T., Vlotides G., Eichhorst S. T., Goke B., Diepolder H., Auernhammer C. J.
RT SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.
RL Biochem. Biophys. Res. Commun. 331:543-548 (2005).
RN [28]; RE0068945.
RX PUBMED: 15240148.
RA Vlotides G., Sorensen A. S., Kopp F., Zitzmann K., Cengic N., Brand S., Zachoval R., Auernhammer C. J.
RT SOCS-1 and SOCS-3 inhibit IFN-alpha-induced expression of the antiviral proteins 2,5-OAS and MxA.
RL Biochem. Biophys. Res. Commun. 320:1007-1014 (2004).
RN [29]; RE0069298.
RX PUBMED: 16585572.
RA Du Z., Kelly E., Mecklenbrauker I., Agle L., Herrero C., Paik P., Ivashkiv L. B.
RT Selective regulation of IL-10 signaling and function by zymosan.
RL J. Immunol. 176:4785-4792 (2006).
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