AC T00992
XX
ID T00992
XX
DT 08.12.1993 (created); ewi.
DT 23.12.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA Hsp90
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SY Heat shock 90 kDa protein; heat shock protein 90; heat shock protein Hsp 90-beta; hsp86; hsp90.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF alpha-, beta-variant;
SF phosphorylation;
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CP (HeLa).
XX
FF cytosolic binding of GR inhibits its nuclear translocation, but facilitates aporeceptor response to hormonal signal;
FF in vitro phosphorylation by CKII;
XX
IN T00018 AhR; mouse, Mus musculus.
IN T00019 AhR; rat, Rattus norvegicus.
IN T01795 AhR; human, Homo sapiens.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T02720 BMAL1; human, Homo sapiens.
IN T00140 c-Myc-isoform1; human, Homo sapiens.
IN T02725 cdk9; human, Homo sapiens.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T34781 ErbB1; human, Homo sapiens.
IN T22597 FLIL; human, Homo sapiens.
IN T00337 GR-alpha; human, Homo sapiens.
IN T01920 GR-beta; human, Homo sapiens.
IN T00333 GR; rat, Rattus norvegicus.
IN T00334 GR; chick, Gallus gallus.
IN T00336 GR; cat, Felis silvestris catus.
IN T05076 GR; human, Homo sapiens.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T00511 MR; rat, Rattus norvegicus.
IN T10416 NFAT5c; human, Homo sapiens.
IN T09956 PPARalpha; Mammalia.
IN T01661 PR A; human, Homo sapiens.
IN T00696 PR B; human, Homo sapiens.
IN T10037 PU.1; Mammalia.
IN T17263 STAT3{pY}; human, Homo sapiens.
XX
DR TRANSPATH: MO000021131.
XX
RN [1]; RE0001042.
RX PUBMED: 2492519.
RA Lees-Miller S. P., Anderson C. W.
RT Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II
RL J. Biol. Chem. 264:2431-2437 (1989).
RN [2]; RE0002825.
RX PUBMED: 2234079.
RA Picard D., Khursheed B., Garabedian M. J., Fortin M. G., Lindquist S., Yamamoto K. R.
RT Reduced levels of hsp90 compromise steroid receptor action in vivo
RL Nature 348:166-168 (1990).
RN [3]; RE0022429.
RX PUBMED: 12052835.
RA Isaacs J. S., Jung Y.-J., Mimnaugh E. G., Martinez A., Cuttitta F., Neckers L. M.
RT Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.
RL J. Biol. Chem. 277:29936-29944 (2002).
RN [4]; RE0025710.
RX PUBMED: 11867521.
RA Wang H., Goode T., Iakova P., Albrecht J. H., Timchenko N. A.
RT C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest.
RL EMBO J. 21:930-41 (2002).
RN [5]; RE0030072.
RX PUBMED: 12574167.
RA Zhou P., Fernandes N., Dodge I. L., Reddi A. L., Rao N., Safran H., DiPetrillo T. A., Wazer D. E., Band V., Band H.
RT ErbB2 degradation mediated by the co-chaperone protein CHIP.
RL J. Biol. Chem. 278:13829-37 (2003).
RN [6]; RE0032314.
RX PUBMED: 12482853.
RA Sumanasekera W. K., Tien E. S., Turpey R., Vanden Heuvel J. P., Perdew G. H.
RT Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2.
RL J. Biol. Chem. 278:4467-73 (2003).
RN [7]; RE0032571.
RX PUBMED: 9880553.
RA Stephanou A., Isenberg D. A., Nakajima K., Latchman D. S.
RT Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters.
RL J. Biol. Chem. 274:1723-8 (1999).
RN [8]; RE0047237.
RX PUBMED: 7594592.
RA Nagulapalli S., Pongubala J. M., Atchison M. L.
RT Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)
RL J. Immunol. 155:4330-8 (1995).
RN [9]; RE0047326.
RX PUBMED: 15538384.
RA Tateishi Y., Kawabe Y., Chiba T., Murata S., Ichikawa K., Murayama A., Tanaka K., Baba T., Kato S., Yanagisawa J.
RT Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.
RL EMBO J. 23:4813-4823 (2004).
RN [10]; RE0047576.
RX PUBMED: 9268713.
RA Takata Y., Imamura T., Iwata M., Usui I., Haruta T., Nandachi N., Ishiki M., Sasaoka T., Kobayashi M.
RT Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis.
RL Biochem. Biophys. Res. Commun. 237:345-347 (1997).
RN [11]; RE0047646.
RX PUBMED: 15289446.
RA Dschietzig T., Bartsch C., Stangl V., Baumann G., Stangl K.
RT Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist.
RL FASEB J. 18:1536-1538 (2004).
RN [12]; RE0047649.
RX PUBMED: 15001357.
RA Burch L., Shimizu H., Smith A., Patterson C., Hupp T. R.
RT Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein.
RL J. Mol. Biol. 337:129-145 (2004).
RN [13]; RE0048007.
RX PUBMED: 12235142.
RA Shah M., Patel K., Fried V. A., Sehgal P. B.
RT Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever.
RL J. Biol. Chem. 277:45662-45669 (2002).
RN [14]; RE0048026.
RX PUBMED: 14614132.
RA Fortugno P., Beltrami E., Plescia J., Fontana J., Pradhan D., Marchisio P. C., Sessa W. C., Altieri D. C.
RT Regulation of survivin function by Hsp90.
RL Proc. Natl. Acad. Sci. USA 100:13791-13796 (2003).
RN [15]; RE0048049.
RX PUBMED: 12621024.
RA Hu Y., Mivechi N. F.
RT HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo.
RL J. Biol. Chem. 278:17299-17306 (2003).
RN [16]; RE0048061.
RX PUBMED: 15001580.
RA Zhang H., Wu W., Du Y., Santos S. J., Conrad S. E., Watson J. T., Grammatikakis N., Gallo K. A.
RT Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.
RL J. Biol. Chem. 279:19457-19463 (2004).
RN [17]; RE0048218.
RX PUBMED: 16226712.
RA Niture S. K., Doneanu C. E., Velu C. S., Bailey N. I., Srivenugopal K. S.
RT Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
RL Biochem. Biophys. Res. Commun. 337:1176-1184 (2005).
RN [18]; RE0048364.
RX PUBMED: 15781642.
RA Cha T. L., Qiu L., Chen C. T., Wen Y., Hung M. C.
RT Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
RL Cancer Res. 65:2287-2295 (2005).
RN [19]; RE0048509.
RX PUBMED: 11533664.
RA Ravagnan L., Gurbuxani S., Susin S. A., Maisse C., Daugas E., Zamzami N., Mak T., Jaattela M., Penninger J. M., Garrido C., Kroemer G.
RT Heat-shock protein 70 antagonizes apoptosis-inducing factor.
RL Nat. Cell Biol. 3:839-843 (2001).
RN [20]; RE0048513.
RX PUBMED: 15632176.
RA Ghatak S., Misra S., Toole B. P.
RT Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.
RL J. Biol. Chem. 280:8875-8883 (2005).
RN [21]; RE0049227.
RX PUBMED: 16968706.
RA Fearns C., Pan Q., Mathison J. C., Chuang T. H.
RT Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
RL J. Biol. Chem. 281:34592-34600 (2006).
RN [22]; RE0049249.
RX PUBMED: 16407408.
RA Rosa J., Canovas P., Islam A., Altieri D. C., Doxsey S. J.
RT Survivin modulates microtubule dynamics and nucleation throughout the cell cycle.
RL Mol. Biol. Cell 17:1483-1493 (2006).
RN [23]; RE0050001.
RX PUBMED: 17024179.
RA Okamoto T., Nishimura Y., Ichimura T., Suzuki K., Miyamura T., Suzuki T., Moriishi K., Matsuura Y.
RT Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
RL EMBO J. 25:5015-5025 (2006).
RN [24]; RE0050336.
RX PUBMED: 17587566.
RA Meyer R., Wolf S. S., Obendorf M.
RT PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
RL J. Steroid Biochem. Mol. Biol. 107:1-14 (2007).
RN [25]; RE0051483.
RX PUBMED: 16020752.
RA Polikandriotis J. A., Mazzella L. J., Rupnow H. L., Hart C. M.
RT Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms.
RL Arterioscler. Thromb. Vasc. Biol. 25:1810-1816 (2005).
RN [26]; RE0051492.
RX PUBMED: 15647277.
RA De Nardo D., Masendycz P., Ho S., Cross M., Fleetwood A. J., Reynolds E. C., Hamilton J. A., Scholz G. M.
RT A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.
RL J. Biol. Chem. 280:9813-9822 (2005).
RN [27]; RE0053580.
RX PUBMED: 18456663.
RA Belova L., Brickley D. R., Ky B., Sharma S. K., Conzen S. D.
RT Hsp90 Regulates the Phosphorylation and Activity of Serum- and Glucocorticoid-regulated Kinase-1.
RL J. Biol. Chem. 283:18821-18831 (2008).
RN [28]; RE0053992.
RX PUBMED: 16037132.
RA Fan M., Park A., Nephew K. P.
RT CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha.
RL Mol. Endocrinol. 19:2901-2914 (2005).
RN [29]; RE0054582.
RX PUBMED: 18388150.
RA Berry N. B., Fan M., Nephew K. P.
RT Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome.
RL Mol. Endocrinol. 22:1535-1551 (2008).
RN [30]; RE0054745.
RX PUBMED: 12421356.
RA McLean P. J., Kawamata H., Shariff S., Hewett J., Sharma N., Ueda K., Breakefield X. O., Hyman B. T.
RT TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.
RL J. Neurochem 83:846-854 (2002).
RN [31]; RE0054862.
RX PUBMED: 17728246.
RA Hinz M., Broemer M., Arslan S. C., Otto A., Mueller E. C., Dettmer R., Scheidereit C.
RT Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90.
RL J. Biol. Chem. 282:32311-32319 (2007).
RN [32]; RE0063150.
RX PUBMED: 19026643.
RA Liu X. Y., Seh C. C., Cheung P. C.
RT HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway.
RL FEBS Lett. 582:4023-4031 (2008).
RN [33]; RE0064062.
RX PUBMED: 15718503.
RA Toporsian M., Gros R., Kabir M. G., Vera S., Govindaraju K., Eidelman D. H., Husain M., Letarte M.
RT A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia.
RL Circ. Res. 96:684-692 (2005).
RN [34]; RE0065057.
RX PUBMED: 16280321.
RA Shang L., Tomasi T. B.
RT The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
RL J. Biol. Chem. 281:1876-1884 (2006).
RN [35]; RE0069412.
RX PUBMED: 19011619.
RA Dogan T., Harms G. S., Hekman M., Karreman C., Oberoi T. K., Alnemri E. S., Rapp U. R., Rajalingam K.
RT X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
RL Nat. Cell Biol. 10:1447-1455 (2008).
XX
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