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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09956 XX ID T09956 XX DT 10.03.2005 (created); nvo. DT 17.07.2014 (updated); msr. CO Copyright (C), QIAGEN. XX FA PPARalpha XX SY NR1C1; peroxisome proliferator-activated receptor alpha; PPARalpha. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T25634 ASC-2; mouse, Mus musculus. IN T17532 Bcl-3; Mammalia. IN T09446 c-Jun; Mammalia. IN T00992 Hsp90; human, Homo sapiens. IN T09402 MEF-2C; Mammalia. IN T08641 NCOR1-isoform1; mouse, Mus musculus. IN T16712 NFATc4; rat, Rattus norvegicus. IN T01427 p300; human, Homo sapiens. IN T28267 PGC-1; Mammalia. IN T09964 RXR-alpha; Mammalia. IN T23084 SHP; Mammalia. IN T08326 Sp1; Mammalia. IN T21552 SRC-1; Mammalia. XX MX M00242 V$PPARA_01. MX M00518 V$PPARA_02. MX M01282 V$PPARA_Q6. MX M00763 V$PPARDR1_Q2. XX BS R35225. BS R27487. BS R33012. BS R61206. XX DR TRANSPATH: MO000047190. XX RN [1]; RE0006015. RX PUBMED: 8895578. RA Schoonjans K., Peinado-Onsurbe J., Lefebvre A.-M., Heyman R. A., Briggs M., Deeb S., Staels B., Auwerx J. RT PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene RL EMBO J. 15:5336-5348 (1996). RN [2]; RE0016813. RX PUBMED: 10336495. RA Dowell P., Ishmael J. E., Avram D., Peterson V. J., Nevrivy D. J., Leid M. RT Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein RL J. Biol. Chem. 274:15901-15907 (1999). RN [3]; RE0018034. RX PUBMED: 9748239. RA Vu-Dac N., Chopin-Delannoy S., Gervois P., Bonnelye E., Martin G., Fruchart J.-C., Laudet V., Staels B. RT The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. RL J. Biol. Chem. 273:25713-25720 (1998). RN [4]; RE0018042. RX PUBMED: 11371553. RA Hsu M.-H., Savas U., Griffin K. J., Johnson E. F. RT Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. RL J. Biol. Chem. 276:27950-27958 (2001). RN [5]; RE0018044. RX PUBMED: 10660604. RA Kassam A., Winrow C. J., Fernandez-Rachubinski F., Capone J. P., Rachubinski R. A. RT The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated transactivation. RL J. Biol. Chem. 275:4345-4350 (2000). RN [6]; RE0018238. RX PUBMED: 12189208. RA Surapureddi S., Yu S., Bu H., Hashimoto T., Yeldandi A. V., Kashireddy P., Cherkaoui-Malki M., Qi C., Zhu Y. J., Rao M. S., Reddy J. K. RT Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. RL Proc. Natl. Acad. Sci. USA 99:11836-11841 (2002). RN [7]; RE0024500. RX PUBMED: 12015306. RA Helledie T., Grontved L., Jensen S. S., Kiilerich P., Rietveld L., Albrektsen T., Boysen M. S., Nohr J., Larsen L. K., Fleckner J., Stunnenberg H. G., Kristiansen K., Mandrup S. RT The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. RL J. Biol. Chem. 277:26821-26830 (2002). RN [8]; RE0026797. RX PUBMED: 10542237. RA Delerive P., De Bosscher K., Besnard S., vanden Berghe W., Peters J. M., Gonzalez F. J., Fruchart J. C., Tedgui A., Haegeman G., Staels B. RT Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. RL J. Biol. Chem. 274:32048-54 (1999). RN [9]; RE0026896. RX PUBMED: 11089532. RA Memon R. A., Tecott L. H., Nonogaki K., Beigneux A., Moser A. H., Grunfeld C., Feingold K. R. RT Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice RL Endocrinology 141:4021-31 (2000). RN [10]; RE0030165. RX PUBMED: 12802337. RA Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N. H., Shibata Y., Terauchi Y., Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. RT Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. RL Nature 423:762-9 (2003). RN [11]; RE0032258. RX PUBMED: 12456495. RA Kintscher U., Lyon C., Wakino S., Bruemmer D., Feng X., Goetze S., Graf K., Moustakas A., Staels B., Fleck E., Hsueh W. A., Law R. E. RT PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. RL Circ. Res. 91:e35-44 (2002). RN [12]; RE0032314. RX PUBMED: 12482853. RA Sumanasekera W. K., Tien E. S., Turpey R., Vanden Heuvel J. P., Perdew G. H. RT Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. RL J. Biol. Chem. 278:4467-73 (2003). RN [13]; RE0032370. RX PUBMED: 12843208. RA Solanes G., Pedraza N., Iglesias R., Giralt M., Villarroya F. RT Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription. RL Mol. Endocrinol. 17:1944-58 (2003). RN [14]; RE0032479. RX PUBMED: 11867749. RA Shi Y., Hon M., Evans R. M. RT The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. RL Proc. Natl. Acad. Sci. USA 99:2613-8 (2002). RN [15]; RE0033003. RX PUBMED: 10473669. RA Delerive P., Martin-Nizard F., Chinetti G., Trottein F., Fruchart J. C., Najib J., Duriez P., Staels B. RT Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. RL Circ. Res. 85:394-402 (1999). RN [16]; RE0033961. RX PUBMED: 15130092. RA Schachtrup C., Emmler T., Bleck B., Sandqvist A., Spener F. RT Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins. RL Biochem. J. 382:239-45 (2004). RN [17]; RE0035597. RX PUBMED: 12408750. RA Barrero M. J., Camarero N., Marrero P. F., Haro D. RT Control of human carnitine palmitoyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element. RL Biochem. J. 369:721-729 (2003). RN [18]; RE0035604. RX PUBMED: 9830040. RA Yu G. S., Lu Y. C., Gulick T. RT Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate. RL J. Biol. Chem. 273:32901-32909 (1998). RN [19]; RE0036448. RX PUBMED: 12706301. RA Lovekamp-Swan T., Jetten A. M., Davis B. J. RT Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells RL Mol. Cell. Endocrinol. 201:133-41 (2003). RN [20]; RE0037033. RX PUBMED: 11422379. RA Fourcade S., Savary S., Albet S., Gauthe D., Gondcaille C., Pineau T., Bellenger J., Bentejac M., Holzinger A., Berger J., Bugaut M. RT Fibrate induction of the adrenoleukodystrophy-related gene (ABCD2): promoter analysis and role of the peroxisome proliferator-activated receptor PPARalpha RL Eur. J. Biochem. 268:3490-500 (2001). RN [21]; RE0037964. RX PUBMED: 9795230. RA Masuda N., Yasumo H., Furusawa T., Tsukamoto T., Sadano H., Osumi T. RT Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors RL Gene 221:225-33 (1998). RN [22]; RE0037994. RX PUBMED: 12897377. RA Heinlein C. A., Chang C. RT Induction and repression of peroxisome proliferator-activated receptor alpha transcription by coregulator ARA70 RL Endocrine 21:139-46 (2003). RN [23]; RE0038171. RX PUBMED: 11418615. RA Gervois P., Vu-Dac N., Kleemann R., Kockx M., Dubois G., Laine B., Kosykh V., Fruchart J. C., Kooistra T., Staels B. RT Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta RL J. Biol. Chem. 276:33471-7 (2001). RN [24]; RE0038430. RX PUBMED: 12955147. RA Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez de Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D. RT Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha RL Nature 425:90-3 (2003). RN [25]; RE0038431. RX PUBMED: 12093797. RA Eberhardt W., Akool el-S, Rebhan J., Frank S., Beck K. F., Franzen R., Hamada F. M., Pfeilschifter J. RT Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability RL J. Biol. Chem. 277:33518-28 (2002). RN [26]; RE0038483. RX PUBMED: 11208679. RA Marx N., Mackman N., Schonbeck U., Yilmaz N., Hombach V. V, Libby P., Plutzky J. RT PPARalpha Activators Inhibit Tissue Factor Expression and Activity in Human Monocytes RL Circulation 103:213-219 (2001). RN [27]; RE0038604. RX PUBMED: 10821819. RA Chinetti G., Gbaguidi F. G., Griglio S., Mallat Z., Antonucci M., Poulain P., Chapman J., Fruchart J. C., Tedgui A., Najib-Fruchart J., Staels B. RT CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors RL Circulation 101:2411-7 (2000). RN [28]; RE0039064. RX PUBMED: 10022764. RA Miyata K. S., McCaw S. E., Meertens L. M., Patel H. V., Rachubinski R. A., Capone J. P. RT Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha RL Mol. Cell. Endocrinol. 146:69-76 (1998). RN [29]; RE0039070. RX PUBMED: 10862772. RA Kersten S., Mandard S., Tan N. S., Escher P., Metzger D., Chambon P., Gonzalez F. J., Desvergne B., Wahli W. RT Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene RL J. Biol. Chem. 275:28488-93 (2000). RN [30]; RE0039102. RX PUBMED: 11342537. RA Bouly M., Masson D., Gross B., Jiang X. C., Fievet C., Castro G., Tall A. R., Fruchart J. C., Staels B., Lagrost L., Luc G. RT Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate RL J. Biol. Chem. 276:25841-7 (2001). RN [31]; RE0039222. RX PUBMED: 14729975. RA Shimizu M., Takeshita A., Tsukamoto T., Gonzalez F. J., Osumi T. RT Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element RL Mol. Cell. Biol. 24:1313-23 (2004). RN [32]; RE0039280. RX PUBMED: 14594999. RA Jiang Y. J., Lu B., Xu F. Y., Gartshore J., Taylor W. A., Halayko A. J., Gonzalez F. J., Takasaki J., Choy P. C., Hatch G. M. RT Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation RL J. Lipid Res. 45:244-52 (2004). RN [33]; RE0039711. RX PUBMED: 15051727. RA Tien E. S., Davis J. W., Vanden Heuvel J. P. RT Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator RL J. Biol. Chem. 279:24053-63 (2004). RN [34]; RE0040841. RX PUBMED: 14715259. RA Chinetti G., Zawadski C., Fruchart J. C., Staels B. RT Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR RL Biochem. Biophys. Res. Commun. 314:151-8 (2004). RN [35]; RE0040858. RX PUBMED: 11886504. RA Kippenberger S., Loitsch S. M., Grundmann-Kollmann M., Simon S., Dang T. A., Hardt-Weinelt K., Kaufmann R., Bernd A. RT Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation RL J. Invest. Dermatol 117:1430-6 (2001). RN [36]; RE0040861. RX PUBMED: 12890579. RA Lopez D., Irby R. B., McLean M. P. RT Peroxisome proliferator-activated receptor alpha induces rat sterol carrier protein x promoter activity through two peroxisome proliferator-response elements RL Mol. Cell. Endocrinol. 205:169-84 (2003). RN [37]; RE0040863. RX PUBMED: 11259402. RA Young M. E., Patil S., Ying J., Depre C., Ahuja H. S., Shipley G. L., Stepkowski S. M., Davies P. J., Taegtmeyer H. RT Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart RL FASEB J. 15:833-45 (2001). RN [38]; RE0040868. RX PUBMED: 11246888. RA Michaud S. E., Renier G. RT Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs RL Diabetes 50:660-6 (2001). RN [39]; RE0040875. RX PUBMED: 9407140. RA Dowell P., Ishmael J. E., Avram D., Peterson V. J., Nevrivy D. J., Leid M. RT p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha RL J. Biol. Chem. 272:33435-43 (1997). RN [40]; RE0040888. RX PUBMED: 12867511. RA Deplanque D., Gele P., Petrault O., Six I., Furman C., Bouly M., Nion S., Dupuis B., Leys D., Fruchart J. C., Cecchelli R., Staels B., Duriez P., Bordet R. RT Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment RL J. Neurosci. 23:6264-71 (2003). RN [41]; RE0040891. RX PUBMED: 12379472. RA Okumura M., Yamamoto M., Sakuma H., Kojima T., Maruyama T., Jamali M., Cooper D. R., Yasuda K. RT Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression RL Biochim. Biophys. Acta 1592:107-16 (2002). RN [42]; RE0040896. RX PUBMED: 11226238. RA Wolfrum C., Borrmann C. M., Borchers T., Spener F. RT Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma -mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus RL Proc. Natl. Acad. Sci. USA 98:2323-2328 (2001). RN [43]; RE0040911. RX PUBMED: 10669761. RA Vega R. B., Huss J. M., Kelly D. P. RT The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes RL Mol. Cell. Biol. 20:1868-76 (2000). RN [44]; RE0040914. RX PUBMED: 10844002. RA Hashimoto T., Cook W. S., Qi C., Yeldandi A. V., Reddy J. K., Rao M. S. RT Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting RL J. Biol. Chem. 275:28918-28 (2000). RN [45]; RE0040916. RX PUBMED: 11594759. RA Hirotani M., Tsukamoto T., Bourdeaux J., Sadano H., Osumi T. RT Stabilization of peroxisome proliferator-activated receptor alpha by the ligand RL Biochem. Biophys. Res. Commun. 288:106-10 (2001). RN [46]; RE0040917. RX PUBMED: 14523052. RA Ramaswamy G., Karim M. A., Murti K. G., Jackowski S. RT PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression RL J. Lipid Res. 45:17-31 (2004). RN [47]; RE0040918. RX PUBMED: 9556573. RA Yan Z. H., Karam W. G., Staudinger J. L., Medvedev A., Ghanayem B. I., Jetten A. M. RT Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4 RL J. Biol. Chem. 273:10948-57 (1998). RN [48]; RE0040920. RX PUBMED: 12582161. RA Barbier O., Villeneuve L., Bocher V., Fontaine C., Torra I. P., Duhem C., Kosykh V., Fruchart J. C., Guillemette C., Staels B. RT The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene RL J. Biol. Chem. 278:13975-13983 (2003). RN [49]; RE0041601. RX PUBMED: 12023905. RA Puckey L. H., Knight B. L. RT Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers RL Biochem. J. 366:157-63 (2002). RN [50]; RE0041613. RX PUBMED: 9855014. RA Peters J. M., Aoyama T., Cattley R. C., Nobumitsu U., Hashimoto T., Gonzalez F. J. RT Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver RL Carcinogenesis 19:1989-94 (1998). RN [51]; RE0041619. RX PUBMED: 12381268. RA Kok T., Bloks V. W., Wolters H., Havinga R., Jansen P. L., Staels B., Kuipers F. RT Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice RL Biochem. J. 369:539-47 (2003). RN [52]; RE0041623. RX PUBMED: 11792729. RA Matsuzaka T., Shimano H., Yahagi N., Amemiya-Kudo M., Yoshikawa T., Hasty A. H., Tamura Y., Osuga J., Okazaki H., Iizuka Y., Takahashi A., Sone H., Gotoda T., Ishibashi S., Yamada N. RT Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha RL J. Lipid Res. 43:107-14 (2002). RN [53]; RE0041764. RX PUBMED: 12475913. RA Lynn F. C., Thompson S. A., Pospisilik J. A., Ehses J. A., Hinke S. A., Pamir N., McIntosh C. H., Pederson R. A. RT A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells RL FASEB J. 17:91-3 (2003). RN [54]; RE0041766. RX PUBMED: 14698034. RA Tomkiewicz C., Muzeau F., Edgar A. D., Barouki R., Aggerbeck M. RT Opposite regulation of the rat and human cytosolic aspartate aminotransferase genes by fibrates RL Biochem. Pharmacol. 67:213-25 (2004). RN [55]; RE0041768. RX PUBMED: 14654352. RA Rampler H., Weinhofer I., Netik A., Forss-Petter S., Brown P. J., Oplinger J. A., Bugaut M., Berger J. RT Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy RL Mol. Genet. Metab. 80:398-407 (2003). RN [56]; RE0041770. RX PUBMED: 12810707. RA Barbier O., Duran-Sandoval D., Pineda-Torra I., Kosykh V., Fruchart J. C., Staels B. RT Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme RL J. Biol. Chem. 278:32852-60 (2003). RN [57]; RE0041772. RX PUBMED: 10187842. RA Juge-Aubry C. E., Hammar E., Siegrist-Kaiser C., Pernin A., Takeshita A., Chin W. W., Burger A. G., Meier C. A. RT Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain RL J. Biol. Chem. 274:10505-10 (1999). RN [58]; RE0041824. RX PUBMED: 11554740. RA Wu P., Peters J. M., Harris R. A. RT Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha RL Biochem. Biophys. Res. Commun. 287:391-6 (2001). RN [59]; RE0041827. RX PUBMED: 12032169. RA Tordjman K., Standley K. N., Bernal-Mizrachi C., Leone T. C., Coleman T., Kelly D. P., Semenkovich C. F. RT PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells RL J. Lipid Res. 43:936-43 (2002). RN [60]; RE0041829. RX PUBMED: 11875072. RA Oberkofler H., Esterbauer H., Linnemayr V., Strosberg A. D., Krempler F., Patsch W. RT Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity RL J. Biol. Chem. 277:16750-7 (2002). RN [61]; RE0041831. RX PUBMED: 9341179. RA Peters J. M., Hennuyer N., Staels B., Fruchart J. C., Fievet C., Gonzalez F. J., Auwerx J. RT Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice RL J. Biol. Chem. 272:27307-12 (1997). RN [62]; RE0041836. RX PUBMED: 11925428. RA Linden D., Lindberg K., Oscarsson J., Claesson C., Asp L., Li L., Gustafsson M., Boren J., Olofsson S. O. RT Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48 RL J. Biol. Chem. 277:23044-53 (2002). RN [63]; RE0041839. RX PUBMED: 14684628. RA Meissner M., Stein M., Urbich C., Reisinger K., Suske G., Staels B., Kaufmann R., Gille J. RT PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation RL Circ. Res. 94:324-32 (2004). RN [64]; RE0041976. RX PUBMED: 10980195. RA Delerive P., Gervois P., Fruchart J. C., Staels B. RT Induction of ikappa balpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators RL J. Biol. Chem. 275:36703-7 (2000). RN [65]; RE0041988. RX PUBMED: 11549245. RA Razeghi P., Young M. E., Abbasi S., Taegtmeyer H. RT Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart RL Biochem. Biophys. Res. Commun. 287:5-10 (2001). RN [66]; RE0041989. RX PUBMED: 11734553. RA Campbell F. M., Kozak R., Wagner A., Altarejos J. Y., Dyck J. R., Belke D. D., Severson D. L., Kelly D. P., Lopaschuk G. D. RT A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase RL J. Biol. Chem. 277:4098-103 (2002). RN [67]; RE0041990. RX PUBMED: 14641110. RA Lee G. Y., Kim N. H., Zhao Z. S., Cha B. S., Kim Y. S. RT Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level RL Biochem. J. 378:983-90 (2004). RN [68]; RE0041992. RX PUBMED: 11412039. RA Ikawa H., Kameda H., Kamitani H., Baek S. J., Nixon J. B., Hsi L. C., Eling T. E. RT Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells RL Exp. Cell Res. 267:73-80 (2001). RN [69]; RE0042094. RX PUBMED: 11934839. RA Marx N., Kehrle B., Kohlhammer K., Grub M., Koenig W., Hombach V., Libby P., Plutzky J. RT PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis RL Circ. Res. 90:703-10 (2002). RN [70]; RE0042095. RX PUBMED: 10448012. RA Poynter M. E., Daynes R. A. RT Age-associated alterations in splenic iNOS regulation: influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin E RL Cell. Immunol. 195:127-36 (1999). RN [71]; RE0042096. RX PUBMED: 14637167. RA Sakuma T., Miyamoto T., Jiang W., Kakizawa T., Nishio S. I., Suzuki S., Takeda T., Oiwa A., Hashizume K. RT Inhibition of peroxisome proliferator-activated receptor alpha signaling by vitamin D receptor RL Biochem. Biophys. Res. Commun. 312:513-9 (2003). RN [72]; RE0042145. RX PUBMED: 11369442. RA Kassam A., Capone J. P., Rachubinski R. A. RT The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase RL Mol. Cell. Endocrinol. 176:49-56 (2001). RN [73]; RE0042147. RX PUBMED: 12562861. RA Tang C., Cho H. P., Nakamura M. T., Clarke S. D. RT Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element RL J. Lipid Res. 44:686-95 (2003). RN [74]; RE0042157. RX PUBMED: 10951268. RA Komuves L. G., Hanley K., Lefebvre A. M., Man M. Q., Ng D. C., Bikle D. D., Williams M. L., Elias P. M., Auwerx J., Feingold K. R. RT Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo RL J. Invest. Dermatol 115:353-60 (2000). RN [75]; RE0042185. RX PUBMED: 9671776. RA Zhou Y. T., Shimabukuro M., Wang M. Y., Lee Y., Higa M., Milburn J. L., Newgard C. B., Unger R. H. RT Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells RL Proc. Natl. Acad. Sci. USA 95:8898-903 (1998). RN [76]; RE0042462. RX PUBMED: 10753967. RA Hanley K., Komuves L. G., Ng D. C., Schoonjans K., He S. S., Lau P., Bikle D. D., Williams M. L., Elias P. M., Auwerx J., Feingold K. R. 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