AC T28267
AS T28487.
XX
ID T28267
XX
DT 10.03.2005 (created); nvo.
DT 10.04.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA PGC-1
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SY PGC-1alpha; PGC-1v; PGC1A; PPARGC1.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T23079 CAR; Mammalia.
IN T09637 ER-alpha; Mammalia.
IN T14760 ERR1; Mammalia.
IN T14067 FOXO1A; Mammalia.
IN T17105 FXR; Mammalia.
IN T28928 HNF-4alpha-Long; mouse, Mus musculus.
IN T05287 HNF-4alpha; mouse, Mus musculus.
IN T08612 HNF-4alpha; Mammalia.
IN T17874 LXR-alpha; Mammalia.
IN T09402 MEF-2C; Mammalia.
IN T09956 PPARalpha; Mammalia.
IN T09098 SREBP-2-isoform1; human, Homo sapiens.
IN T16580 T3R-beta; Mammalia.
IN T10807 USF; Mammalia.
IN T09133 YY1; Mammalia.
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BS R56907.
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DR TRANSPATH: MO000047785.
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RN [1]; RE0023919.
RX PUBMED: 14744933.
RA Fan M., Rhee J., St-Pierre J., Handschin C., Puigserver P., Lin J., Jaeger S., Erdjument-Bromage H., Tempst P., Spiegelman B. M.
RT Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1{alpha}: modulation by p38 MAPK.
RL Genes Dev. 18:278-289 (2004).
RN [2]; RE0027754.
RX PUBMED: 10558993.
RA Puigserver P., Adelmant G., Wu Z., Fan M., Xu J., O'Malley B., Spiegelman B. M.
RT Activation of PPARgamma coactivator-1 through transcription factor docking.
RL Science 286:1368-71 (1999).
RN [3]; RE0027858.
RX PUBMED: 11274399.
RA Michael L. F., Wu Z., Cheatham R. B., Puigserver P., Adelmant G., Lehman J. J., Kelly D. P., Spiegelman B. M.
RT Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.
RL Proc. Natl. Acad. Sci. USA 98:3820-5 (2001).
RN [4]; RE0030762.
RX PUBMED: 14729567.
RA Zhang Y., Castellani L. W., Sinal C. J., Gonzalez F. J., Edwards P. A.
RT Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.
RL Genes Dev. 18:157-69 (2004).
RN [5]; RE0034840.
RX PUBMED: 15322103.
RA Bhalla S., Ozalp C., Fang S., Xiang L., Kemper J. K.
RT Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
RL J. Biol. Chem. 279:45139-47 (2004).
RN [6]; RE0035594.
RX PUBMED: 12611894.
RA Moore M. L., Park E. A., McMillin J. B.
RT Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1.
RL J. Biol. Chem. 278:17263-17268 (2003).
RN [7]; RE0038403.
RX PUBMED: 15107844.
RA Koo S. H., Satoh H., Herzig S., Lee C. H., Hedrick S., Kulkarni R., Evans R. M., Olefsky J., Montminy M.
RT PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
RL Nat. Med. 10:530-4 (2004).
RN [8]; RE0040911.
RX PUBMED: 10669761.
RA Vega R. B., Huss J. M., Kelly D. P.
RT The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
RL Mol. Cell. Biol. 20:1868-76 (2000).
RN [9]; RE0041788.
RX PUBMED: 12468452.
RA Baar K., Wende A. R., Jones T. E., Marison M., Nolte L. A., Chen M., Kelly D. P., Holloszy J. O.
RT Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
RL FASEB J. 16:1879-86 (2002).
RN [10]; RE0046553.
RX PUBMED: 12397057.
RA Ichida M., Nemoto S., Finkel T.
RT Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha)
RL J. Biol. Chem. 277:50991-5 (2002).
RN [11]; RE0046688.
RX PUBMED: 12181319.
RA Huss J. M., Kopp R. P., Kelly D. P.
RT Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha
RL J. Biol. Chem. 277:40265-74 (2002).
RN [12]; RE0046689.
RX PUBMED: 12551939.
RA Shiraki T., Sakai N., Kanaya E., Jingami H.
RT Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state
RL J. Biol. Chem. 278:11344-50 (2003).
RN [13]; RE0046690.
RX PUBMED: 12754525.
RA Puigserver P., Rhee J., Donovan J., Walkey C. J., Yoon J. C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., Spiegelman B. M.
RT Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
RL Nature 423:550-5 (2003).
RN [14]; RE0046714.
RX PUBMED: 10748020.
RA Tcherepanova I., Puigserver P., Norris J. D., Spiegelman B. M., McDonnell D. P.
RT Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1
RL J. Biol. Chem. 275:16302-8 (2000).
RN [15]; RE0051054.
RX PUBMED: 17636037.
RA Ponugoti B., Fang S., Kemper J. K.
RT Functional interaction of HNF-4 and PGC-1{alpha} in CYP7A1 regulation is inhibited by a key lipogenic activator, SREBP-1c.
RL Mol. Endocrinol. 11:2698-712 (2007).
RN [16]; RE0051163.
RX PUBMED: 15329387.
RA Savkur R. S., Thomas J. S., Bramlett K. S., Gao Y., Michael L. F., Burris T. P.
RT Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha.
RL J. Pharmacol. Exp. Ther. 312:170-178 (2005).
RN [17]; RE0051310.
RX PUBMED: 16354658.
RA Albers M., Blume B., Schlueter T., Wright M. B., Kober I., Kremoser C., Deuschle U., Koegl M.
RT A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
RL J. Biol. Chem. 281:4920-4930 (2006).
RN [18]; RE0052227.
RX PUBMED: 11733490.
RA Lin J., Puigserver P., Donovan J., Tarr P., Spiegelman B. M.
RT Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
RL J. Biol. Chem. 277:1645-1648 (2002).
RN [19]; RE0052650.
RX PUBMED: 16825189.
RA Ding X., Lichti K., Kim I., Gonzalez F. J., Staudinger J. L.
RT Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.
RL J. Biol. Chem. 281:26540-26551 (2006).
RN [20]; RE0053294.
RX PUBMED: 15826954.
RA Iordanidou P., Aggelidou E., Demetriades C., Hadzopoulou-Cladaras M.
RT Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.
RL J. Biol. Chem. 280:21810-21819 (2005).
RN [21]; RE0053638.
RX PUBMED: 16488887.
RA Song K. H., Li T., Chiang J. Y.
RT A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
RL J. Biol. Chem. 281:10081-10088 (2006).
RN [22]; RE0066887.
RX PUBMED: 20404331.
RA Brault J. J., Jespersen J. G., Goldberg A. L.
RT PGC-1{alpha} or PGC-1{beta} (peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} or 1{beta}) overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.
RL J. Biol. Chem. 285:19460-19471 (2010).
RN [23]; RE0067583.
RX PUBMED: 20661474.
RA Kong X., Wang R., Xue Y., Liu X., Zhang H., Chen Y., Fang F., Chang Y.
RT Sirtuin 3, a New Target of PGC-1alpha, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis.
RL PLoS ONE 5:e11707 (2010).
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