AC T14067
XX
ID T14067
XX
DT 10.03.2005 (created); nvo.
DT 14.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA FOXO1A
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SY FKH1; FKHR; forkhead box O1A (rhabdomyosarcoma); FOXO1; FOXO1A.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T09552 AML3; Mammalia.
IN T15601 AR; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T15118 CBP; Mammalia.
IN T09637 ER-alpha; Mammalia.
IN T14713 FOXK1; mouse, Mus musculus.
IN T05252 HDAC5; human, Homo sapiens.
IN T05288 HNF-4alpha; rat, Rattus norvegicus.
IN T08612 HNF-4alpha; Mammalia.
IN T23091 p300; Mammalia.
IN T28267 PGC-1; Mammalia.
IN T16056 RBPJK; Mammalia.
IN T23084 SHP; Mammalia.
IN T18012 SIR2L6; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T30703 SIRT1; Mammalia.
IN T14323 Skp2; Mammalia.
IN T21552 SRC-1; Mammalia.
IN T14458 STAT3; Mammalia.
IN T30562 tuberin; human, Homo sapiens.
XX
MX M07286 V$FOXO1A_Q3.
MX M03823 V$FOXO1A_Q5.
MX M00473 V$FOXO1_01.
MX M00474 V$FOXO1_02.
MX M01968 V$FOXO1_03.
MX M01969 V$FOXO1_04.
MX M01216 V$FOXO1_Q5.
XX
BS R35134.
BS R35147.
BS R35148.
BS R35149.
BS R35150.
BS R35151.
BS R35152.
BS R35153.
BS R35154.
BS R35155.
BS R35156.
BS R35157.
BS R35158.
BS R35159.
BS R35160.
BS R35161.
BS R35162.
BS R35163.
BS R35164.
BS R35165.
BS R35166.
BS R35167.
BS R35168.
BS R35169.
BS R35170.
BS R35171.
BS R35172.
BS R35173.
BS R35174.
BS R35175.
BS R35176.
BS R35177.
BS R35178.
BS R35179.
BS R35180.
BS R35181.
BS R35182.
BS R35183.
BS R35184.
BS R35185.
BS R35186.
BS R35187.
BS R35188.
BS R35189.
BS R35190.
BS R41028.
BS R63920.
BS R63924.
BS R33291.
BS R39264.
BS R66301.
BS R30841.
BS R30842.
BS R36125.
BS R67621.
BS R26514.
BS R39261.
BS R41047.
BS R23163.
BS R23167.
BS R62312.
BS R62314.
BS R26389.
BS R26391.
BS R33533.
BS R26328.
BS R33537.
BS R31044.
BS R31045.
BS R31046.
BS R33548.
BS R30914.
BS R30915.
BS R30916.
BS R30980.
BS R28371.
BS R66664.
BS R62793.
BS R31028.
BS R33809.
BS R33810.
BS R56986.
BS R56987.
XX
DR TRANSPATH: MO000048079.
XX
RN [1]; RE0025505.
RX PUBMED: 12482965.
RA Li P., Lee H., Guo S., Unterman T. G., Jenster G., Bai W.
RT AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.
RL Mol. Cell. Biol. 23:104-118 (2003).
RN [2]; RE0028944.
RX PUBMED: 11435445.
RA Schuur E. R., Loktev A. V., Sharma M., Sun Z., Roth R. A., Weigel R. J.
RT Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.
RL J. Biol. Chem. 276:33554-60 (2001).
RN [3]; RE0033289.
RX PUBMED: 15220471.
RA Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A.
RT Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 101:10042-7 (2004).
RN [4]; RE0035532.
RX PUBMED: 12820900.
RA Furuyama T., Kitayama K., Yamashita H., Mori N.
RT Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation.
RL Biochem. J. 375:365-371 (2003).
RN [5]; RE0035780.
RX PUBMED: 16076959.
RA Matsuzaki H., Daitoku H., Hatta M., Aoyama H., Yoshimochi K., Fukamizu A.
RT Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.
RL Proc. Natl. Acad. Sci. USA 102:11278-11283 (2005).
RN [6]; RE0038462.
RX PUBMED: 12519792.
RA Hirota K., Daitoku H., Matsuzaki H., Araya N., Yamagata K., Asada S., Sugaya T., Fukamizu A.
RT Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
RL J. Biol. Chem. 278:13056-60 (2003).
RN [7]; RE0040645.
RX PUBMED: 15256269.
RA Orth H. M., Kruger K. D., Schmoll D., Grempler R., Scherbaum W. A., Joost H. G., Bornstein S. R., Barthel A.
RT Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a)
RL Regul. Pept. 121:19-24 (2004).
RN [8]; RE0040646.
RX PUBMED: 10698940.
RA Nakae J., Barr V., Accili D.
RT Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
RL EMBO J. 19:989-96 (2000).
RN [9]; RE0041343.
RX PUBMED: 12456685.
RA Kortylewski M., Feld F., Kruger K. D., Bahrenberg G., Roth R. A., Joost H. G., Heinrich P. C., Behrmann I., Barthel A.
RT Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
RL J. Biol. Chem. 278:5242-9 (2003).
RN [10]; RE0042169.
RX PUBMED: 11030146.
RA Jackson J. G., Kreisberg J. I., Koterba A. P., Yee D., Brattain M. G.
RT Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells
RL Oncogene 19:4574-81 (2000).
RN [11]; RE0042202.
RX PUBMED: 12560069.
RA Mazumdar A., Kumar R.
RT Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells
RL FEBS Lett. 535:6-10 (2003).
RN [12]; RE0042872.
RX PUBMED: 15047713.
RA Yamagata K., Daitoku H., Shimamoto Y., Matsuzaki H., Hirota K., Ishida J., Fukamizu A.
RT Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
RL J. Biol. Chem. 279:23158-65 (2004).
RN [13]; RE0046690.
RX PUBMED: 12754525.
RA Puigserver P., Rhee J., Donovan J., Walkey C. J., Yoon J. C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., Spiegelman B. M.
RT Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
RL Nature 423:550-5 (2003).
RN [14]; RE0048305.
RX PUBMED: 16107711.
RA Bois P. R., Brochard V. F., Salin-Cantegrel A. V., Cleveland J. L., Grosveld G. C.
RT FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion.
RL Mol. Cell. Biol. 25:7645-7656 (2005).
RN [15]; RE0048309.
RX PUBMED: 15668399.
RA Huang H., Regan K. M., Wang F., Wang D., Smith D. I., van Deursen J. M., Tindall D. J.
RT Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
RL Proc. Natl. Acad. Sci. USA 102:1649-1654 (2005).
RN [16]; RE0048317.
RX PUBMED: 15692560.
RA Yang Y., Hou H., Haller E. M., Nicosia S. V., Bai W.
RT Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
RL EMBO J. 24:1021-1032 (2005).
RN [17]; RE0051245.
RX PUBMED: 17965779.
RA Li H. H., Willis M. S., Lockyer P., Miller N., McDonough H., Glass D. J., Patterson C.
RT Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.
RL J. Clin. Invest. 117:3211-3223 (2007).
RN [18]; RE0053316.
RX PUBMED: 18420577.
RA Housley M. P., Rodgers J. T., Udeshi N. D., Kelly T. J., Shabanowitz J., Hunt D. F., Puigserver P., Hart G. W.
RT O-GlcNAc Regulates FoxO Activation in Response to Glucose.
RL J. Biol. Chem. 283:16283-16292 (2008).
RN [19]; RE0055916.
RX PUBMED: 11311120.
RA Woods Y. L., Rena G., Morrice N., Barthel A., Becker W., Guo S., Unterman T. G., Cohen P.
RT The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
RL Biochem. J. 355:597-607 (2001).
RN [20]; RE0055918.
RX PUBMED: 17717603.
RA Kitamura T., Kitamura Y. I., Funahashi Y., Shawber C. J., Castrillon D. H., Kollipara R., DePinho R. A., Kitajewski J., Accili D.
RT A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
RL J. Clin. Invest. 117:2477-2485 (2007).
RN [21]; RE0065175.
RX PUBMED: 17030088.
RA Nechamen C. A., Thomas R. M., Dias J. A.
RT APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.
RL Mol. Cell. Endocrinol. 260-262:93-99 (2007).
RN [22]; RE0067326.
RX PUBMED: 15683364.
RA King J. A., Straffon A. F., D'Abaco G. M., Poon C. L., I S. T., Smith C. M., Buchert M., Corcoran N. M., Hall N. E., Callus B. A., Sarcevic B., Martin D., Lock P., Hovens C. M.
RT Distinct requirements for the Sprouty domain for functional activity of Spred proteins.
RL Biochem. J. 388:445-454 (2005).
RN [23]; RE0067774.
RX PUBMED: 17077083.
RA Cao Y., Kamioka Y., Yokoi N., Kobayashi T., Hino O., Onodera M., Mochizuki N., Nakae J.
RT Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
RL J. Biol. Chem. 281:40242-40251 (2006).
RN [24]; RE0070180.
RX PUBMED: 20543840.
RA Zhao Y., Yang J., Liao W., Liu X., Zhang H., Wang S., Wang D., Feng J., Yu L., Zhu W. G.
RT Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
RL Nat. Cell Biol. 12:665-675 (2010).
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