AC T29717
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ID T29717
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DT 04.02.2002 (created); cch.
DT 26.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA SIRT1
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SY RP11-57G10.3; silent information regulator type 1; SIR2-like protein 1; SIR2alpha; SIR2L1; SIRT1; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1; sirtuin type 1; yeast silent information regulator 2 (Sir2p) homolog.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003806 SIRT1; HGNC: SIRT1.
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IN T00040 AR; human, Homo sapiens.
IN T04891 CLOCK; human, Homo sapiens.
IN T06570 Dnmt1; human, Homo sapiens.
IN T10353 FOXO1A; human, Homo sapiens.
IN T14067 FOXO1A; Mammalia.
IN T02938 FOXO3a; human, Homo sapiens.
IN T01686 GCN5; human, Homo sapiens.
IN T08522 HDAC4-isoform1; human, Homo sapiens.
IN T06375 ING1b; human, Homo sapiens.
IN T25624 p/CAF; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T10397 RelA-p65; Mammalia.
IN T01853 Sox-9; human, Homo sapiens.
IN T08732 STAT5B; mouse, Mus musculus.
IN T09314 STAT5B; human, Homo sapiens.
IN T16642 TFIIA-alpha/beta precursor; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
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BS R58989.
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DR TRANSPATH: MO000023365.
DR UniProtKB: Q96EB6;
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RN [1]; RE0020825.
RX PUBMED: 11672522.
RA Luo J., Nikolaev A. Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W.
RT Negative control of p53 by Sir2alpha promotes cell survival under stress
RL Cell 107:137-148 (2001).
RN [2]; RE0048066.
RX PUBMED: 12887892.
RA Fulco M., Schiltz R. L., Iezzi S., King M. T., Zhao P., Kashiwaya Y., Hoffman E., Veech R. L., Sartorelli V.
RT Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.
RL Mol. Cell 12:51-62 (2003).
RN [3]; RE0048317.
RX PUBMED: 15692560.
RA Yang Y., Hou H., Haller E. M., Nicosia S. V., Bai W.
RT Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
RL EMBO J. 24:1021-1032 (2005).
RN [4]; RE0049242.
RX PUBMED: 16923962.
RA Fu M., Liu M., Sauve A. A., Jiao X., Zhang X., Wu X., Powell M. J., Yang T., Gu W., Avantaggiati M. L., Pattabiraman N., Pestell T. G., Wang F., Quong A. A., Wang C., Pestell R. G.
RT Hormonal control of androgen receptor function through SIRT1.
RL Mol. Cell. Biol. 26:8122-8135 (2006).
RN [5]; RE0051864.
RX PUBMED: 17000776.
RA Liu Y., Smith P. W., Jones D. R.
RT Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.
RL Mol. Cell. Biol. 26:8683-8696 (2006).
RN [6]; RE0052155.
RX PUBMED: 15152190.
RA Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W.
RT Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
RL EMBO J. 23:2369-2380 (2004).
RN [7]; RE0055189.
RX PUBMED: 15469825.
RA Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., Reinberg D.
RT Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
RL Mol. Cell 16:93-105 (2004).
RN [8]; RE0064434.
RX PUBMED: 18193082.
RA Binda O., Nassif C., Branton P. E.
RT SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins.
RL Oncogene 27:3384-3392 (2008).
RN [9]; RE0067815.
RX PUBMED: 18482975.
RA Hou X., Xu S., Maitland-Toolan K. A., Sato K., Jiang B., Ido Y., Lan F., Walsh K., Wierzbicki M., Verbeuren T. J., Cohen R. A., Zang M.
RT SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
RL J. Biol. Chem. 283:20015-20026 (2008).
RN [10]; RE0068047.
RX PUBMED: 18687677.
RA Lan F., Cacicedo J. M., Ruderman N., Ido Y.
RT SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
RL J. Biol. Chem. 283:27628-27635 (2008).
RN [11]; RE0069450.
RX PUBMED: 21245319.
RA Liu X., Wang D., Zhao Y., Tu B., Zheng Z., Wang L., Wang H., Gu W., Roeder R. G., Zhu W. G.
RT Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
RL Proc. Natl. Acad. Sci. USA 108:1925-1930 (2011).
RN [12]; RE0070207.
RX PUBMED: 20733005.
RA An B. S., Tavera-Mendoza L. E., Dimitrov V., Wang X., Calderon M. R., Wang H. J., White J. H.
RT Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.
RL Mol. Cell. Biol. 30:4890-4900 (2010).
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