AC T09314
XX
ID T09314
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DT 11.09.2006 (created); kar.
DT 20.03.2014 (updated); prb.
CO Copyright (C), QIAGEN.
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FA STAT5B
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SY signal transducer and activator of transcription 5b; STAT5B.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002607 STAT5B; HGNC: STAT5B.
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CL C0039; STAT.
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SZ 787 AA; 89.9 kDa (cDNA) (calc.).
XX
SQ MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
SQ LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
SQ REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
SQ RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
SQ RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
SQ QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
SQ NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
SQ LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
SQ TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SQ SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
SQ QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
SQ GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
SQ GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
SQ WIPHAQS
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SC Swiss-Prot#P51692-1
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IN T29717 SIRT1; human, Homo sapiens.
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MX M00459 V$STAT5B_01.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R10510.
BS R10511.
BS R10512.
BS R10513.
BS R10514.
BS R10515.
BS R10516.
BS R10517.
BS R10518.
BS R10519.
BS R10520.
BS R10521.
BS R10522.
BS R10523.
BS R10524.
BS R10525.
BS R10526.
BS R10527.
BS R10528.
BS R10529.
BS R10530.
BS R10531.
BS R10532.
BS R10533.
BS R10534.
BS R10535.
BS R10536.
BS R10537.
BS R10538.
BS R10539.
BS R10540.
BS R10541.
BS R10542.
BS R10543.
BS R10544.
BS R10545.
BS R10546.
BS R10547.
BS R10548.
BS R10549.
BS R10550.
BS R10551.
BS R10552.
BS R10553.
BS R10554.
BS R10555.
BS R14236.
BS R72374.
BS R72376.
BS R72378.
BS R14311.
BS R38411.
BS R22320.
BS R72368.
BS R22459.
BS R13351.
XX
DR TRANSPATH: MO000086991.
DR EMBL: U47686;
DR EMBL: U48730;
DR UniProtKB: P51692-1;
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RN [1]; RE0016782.
RX PUBMED: 10594041.
RA Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J.
RT DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.
RL Mol. Cell. Biol. 20:389-401 (2000).
RN [2]; RE0017746.
RX PUBMED: 9111365.
RA Matsumura I., Ishikawa J., Nakajima K., Oritani K., Tomiyama Y., Miyagawa J., Kato T., Miyazaki H., Matsuzawa Y., Kanakura Y.
RT Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5.
RL Mol. Cell. Biol. 17:2933-2943 (1997).
RN [3]; RE0019123.
RX PUBMED: 8732682.
RA SILVA C.M., LU H., DAY R.N.
RT Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.
RL Mol. Endocrinol. 10:508-518 (1996).
RN [4]; RE0019124.
RX PUBMED: 8631883.
RA LIN J.X., MIETZ J., MODI W.S., JOHN S., LEONARD W.J.
RT Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
RL J. Biol. Chem. 271:10738-10744 (1996).
RN [5]; RE0023476.
RX PUBMED: 12411494.
RA Klejman A., Schreiner S. J., Nieborowska-Skorska M., Slupianek A., Wilson M., Smithgall T. E., Skorski T.
RT The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
RL EMBO J. 21:5766-5774 (2002).
RN [6]; RE0042419.
RX PUBMED: 12429742.
RA Kloth M. T., Laughlin K. K., Biscardi J. S., Boerner J. L., Parsons S. J., Silva C. M.
RT STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor
RL J. Biol. Chem. 278:1671-9 (2003).
RN [7]; RE0055797.
RX PUBMED: 16772534.
RA Weaver A. M., Silva C. M.
RT Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain.
RL Mol. Endocrinol. 20:2392-2405 (2006).
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