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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09314 XX ID T09314 XX DT 11.09.2006 (created); kar. DT 20.03.2014 (updated); prb. CO Copyright (C), QIAGEN. XX FA STAT5B XX SY signal transducer and activator of transcription 5b; STAT5B. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002607 STAT5B; HGNC: STAT5B. XX CL C0039; STAT. XX SZ 787 AA; 89.9 kDa (cDNA) (calc.). XX SQ MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL SQ LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV SQ REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL SQ RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL SQ RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC SQ QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL SQ NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS SQ LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA SQ TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN SQ SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK SQ QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL SQ GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG SQ GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ SQ WIPHAQS XX SC Swiss-Prot#P51692-1 XX IN T29717 SIRT1; human, Homo sapiens. XX MX M00459 V$STAT5B_01. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R10510. BS R10511. BS R10512. BS R10513. BS R10514. BS R10515. BS R10516. BS R10517. BS R10518. BS R10519. BS R10520. BS R10521. BS R10522. BS R10523. BS R10524. BS R10525. BS R10526. BS R10527. BS R10528. BS R10529. BS R10530. BS R10531. BS R10532. BS R10533. BS R10534. BS R10535. BS R10536. BS R10537. BS R10538. BS R10539. BS R10540. BS R10541. BS R10542. BS R10543. BS R10544. BS R10545. BS R10546. BS R10547. BS R10548. BS R10549. BS R10550. BS R10551. BS R10552. BS R10553. BS R10554. BS R10555. BS R14236. BS R72374. BS R72376. BS R72378. BS R14311. BS R38411. BS R22320. BS R72368. BS R22459. BS R13351. XX DR TRANSPATH: MO000086991. DR EMBL: U47686; DR EMBL: U48730; DR UniProtKB: P51692-1; XX RN [1]; RE0016782. RX PUBMED: 10594041. RA Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J. RT DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. RL Mol. Cell. Biol. 20:389-401 (2000). RN [2]; RE0017746. RX PUBMED: 9111365. RA Matsumura I., Ishikawa J., Nakajima K., Oritani K., Tomiyama Y., Miyagawa J., Kato T., Miyazaki H., Matsuzawa Y., Kanakura Y. RT Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5. RL Mol. Cell. Biol. 17:2933-2943 (1997). RN [3]; RE0019123. RX PUBMED: 8732682. RA SILVA C.M., LU H., DAY R.N. RT Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. RL Mol. Endocrinol. 10:508-518 (1996). RN [4]; RE0019124. RX PUBMED: 8631883. RA LIN J.X., MIETZ J., MODI W.S., JOHN S., LEONARD W.J. RT Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. RL J. Biol. Chem. 271:10738-10744 (1996). RN [5]; RE0023476. RX PUBMED: 12411494. RA Klejman A., Schreiner S. J., Nieborowska-Skorska M., Slupianek A., Wilson M., Smithgall T. E., Skorski T. RT The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. RL EMBO J. 21:5766-5774 (2002). RN [6]; RE0042419. RX PUBMED: 12429742. RA Kloth M. T., Laughlin K. K., Biscardi J. S., Boerner J. L., Parsons S. J., Silva C. M. RT STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor RL J. Biol. Chem. 278:1671-9 (2003). RN [7]; RE0055797. RX PUBMED: 16772534. RA Weaver A. M., Silva C. M. RT Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain. RL Mol. Endocrinol. 20:2392-2405 (2006). XX //