AC T00885
XX
ID T00885
XX
DT 28.01.1993 (created); hse.
DT 13.06.2016 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA VDR
XX
SY 1,25-dihydroxyvitamin D3 receptor; NR1I1; VDR; vitamin D receptor; Vitamin D3 Receptor.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002933 VDR; HGNC: VDR.
XX
CL C0002; CC (rec); 2.1.2.4.1.
XX
SF phosphorylation;
SF LBD (ligand-binding domain) contains 11 alpha-helical region H1 and H3-H12 (H2 is missing, H4 + H5 and H10 + H11 are back-to-back) [12];
SF C-terminal extension (CTE, pos. 88 to 112) that immediately follows the DNA-binding domain necessary for binding to DNA recognition sequence (VDRE-subtype: two direct hexamer repeats with a spacer of 3 bp) [11];
XX
CP (human cell lines): differentiated epithelial line T-47D, intestinal (HeLa-contaminated) line 407 (ATCC-No.) and promyelocytic line HL-60 [5]; MCF-7, HeLa cells [36]; high level of expression in MCF-7, HeLa cells and low level of expression in COS-7, EA.hy926 cells [37].
EX adrenal gland (right and left),,,adult; low; immunohistochemistry / immunocytochemistry; protein; [16].
EX brain,,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX breast,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX colon,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX heart,,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX kidney (right and left),,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX liver,,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX lung (right and left),,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX lymph node,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX ovary (right and left),,,adult; low; immunohistochemistry / immunocytochemistry; protein; [16].
EX pancreas,,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX parathyroid gland,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX prostate gland,,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX skin,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX spleen,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX stomach,,,adult; low; immunohistochemistry / immunocytochemistry; protein; [16].
EX testis (right and left),,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX thyroid gland,,,adult; high; immunohistochemistry / immunocytochemistry; protein; [16].
EX tongue,,,adult; medium; immunohistochemistry / immunocytochemistry; protein; [16].
EX urinary bladder,,,adult; low; immunohistochemistry / immunocytochemistry; protein; [16].
XX
FF native ligand is 1,25-dihydroxyvitamin D3 [14];
FF induces myeloid leukemic cells to differentiate into monocytes/macrophages [6];
XX
IN T02441 AML3; rat, Rattus norvegicus.
IN T15118 CBP; Mammalia.
IN T19642 CDCA7L; human, Homo sapiens.
IN T02938 FOXO3a; human, Homo sapiens.
IN T03403 foxo4; human, Homo sapiens.
IN T28749 HMGN3; human, Homo sapiens.
IN T26695 HSPC195; human, Homo sapiens.
IN T14793 Pit-1; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01359 RXR-alpha; clawed frog, Xenopus laevis.
IN T04383 RXR-alpha; rat, Rattus norvegicus.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T01332 RXR-beta; mouse, Mus musculus.
IN T01334 RXR-beta; human, Homo sapiens.
IN T01349 RXR-beta; rat, Rattus norvegicus.
IN T04807 RXR-gamma; human, Homo sapiens.
IN T02738 SHP; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T04597 SKIP; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T22422 SRC3-xbb2; human, Homo sapiens.
IN T04640 SRC3; human, Homo sapiens.
IN T00818 TFIIB; human, Homo sapiens.
IN T08496 TFIIB; human, Homo sapiens.
IN T17428 TFIIB; Mammalia.
IN T19335 TIF1a-short; human, Homo sapiens.
IN T08439 TIF2; mouse, Mus musculus.
IN T01355 TRAP; human, Homo sapiens.
IN T30562 tuberin; human, Homo sapiens.
XX
MX M00966 V$DR3_Q4.
MX M08979 V$VDR_02.
MX M00444 V$VDR_Q3.
MX M00961 V$VDR_Q6.
MX M03569 V$VDR_Q6_01.
XX
BS R10027.
BS R10030.
BS R01187.
BS R73676.
BS R57206.
BS R05091.
BS R64938.
BS R72609.
BS R72610.
BS R72611.
BS R72612.
BS R19363.
BS R19174.
BS R62279.
BS R38699.
BS R35811.
BS R28382.
BS R60841.
BS R56156.
BS R56164.
BS R56166.
BS R62776.
BS R73602.
BS R20826.
BS R59168.
BS R73578.
BS R69724.
BS R36268.
BS R10003.
BS R34964.
BS R20610.
BS R19259.
BS R20813.
BS R03524.
XX
DR TRANSPATH: MO000021495.
DR TRANSCOMPEL: C00353.
DR TRANSCOMPEL: C00358.
DR TRANSCOMPEL: C00364.
DR PATHODB: MT010606.
DR PATHODB: MT010607.
DR PATHODB: MT010608.
DR PATHODB: MT010609.
DR PATHODB: MT010612.
DR PATHODB: MT010613.
DR PATHODB: MT010614.
DR PATHODB: MT010615.
DR PATHODB: MT010616.
DR PATHODB: MT010617.
DR PATHODB: MT010618.
DR PATHODB: MT010619.
DR PATHODB: MT010620.
DR PATHODB: MT010621.
DR PATHODB: MT010622.
DR PATHODB: MT010623.
DR PATHODB: MT010624.
DR PATHODB: MT010625.
DR PATHODB: MT010626.
DR PATHODB: MT010632.
DR UniProtKB: P11473;
XX
RN [1]; RE0000117.
RX PUBMED: 2159384.
RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado J., Pike J. W., Evans R. M.
RT Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene
RL Cell 61:497-504 (1990).
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RA Yu V. C., Delsert C., Andersen B., Holloway J. M., Devary O. V., Naeaer A. M., Kim S. Y., Boutin J. M., Glass C. K., Rosenfeld M. G.
RT RXRbeta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors of their cognate response elements
RL Cell 67:1251-1266 (1991).
RN [3]; RE0001084.
RX PUBMED: 8389356.
RA Rosen E. D., Beninghof E. G., Koenig R. J.
RT Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors
RL J. Biol. Chem. 268:11534-11541 (1993).
RN [4]; RE0001918.
RX PUBMED: 1310351.
RA Kliewer S. A., Umesono K., Mangelsdorf D. J., Evans R. M.
RT Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling
RL Nature 355:446-449 (1992).
RN [5]; RE0002373.
RX PUBMED: 2835767.
RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W.
RT Cloning and expression of full-length cDNA encoding human vitamin D receptor
RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988).
RN [6]; RE0004157.
RX PUBMED: 8566748.
RA Liu M., Lee M.-H., Cohen M., Bommakanti M., Freedman L. P.
RT Transcription activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.
RL Genes Dev. 10:142-153 (1996).
RN [7]; RE0006261.
RX PUBMED: 7878015.
RA Blanco J. C. G., Wang I.-M., Tsai S. Y., Tsai M.-J., O'Malley B. W., Jurutka P. W., Haussler M. R., Ozato K.
RT Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription
RL Proc. Natl. Acad. Sci. USA 92:1535-1539 (1995).
RN [8]; RE0012321.
RX PUBMED: 8622969.
RA Jurutka P. W., Hsieh J.-C., Nakajima S., Haussler C. A., Whitfield G. K., Haussler M. R.
RT Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation
RL Proc. Natl. Acad. Sci. USA 93:3519-3524 (1996).
RN [9]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [10]; RE0015312.
RX PUBMED: 8392085.
RA Kristjansson K., Rut A. R., Hewison M., O'Riordan J. L., Hughes M. R.
RT Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3
RL J. Clin. Invest. 92:12-16 (1993).
RN [11]; RE0015355.
RX PUBMED: 10587460.
RA Hsieh J. C., Whitfield G. K., Oza A. K., Dang H. T., Price J. N., Galligan M. A., Jurutka P. W., Thompson P. D., Haussler C. A., Haussler M. R.
RT Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor
RL Biochemistry 38:16347-16358 (1999).
RN [12]; RE0015356.
RX PUBMED: 10677485.
RA Yamamoto K., Masuno H., Choi M., Nakashima K., Taga T., Ooizumi H., Umesono K., Sicinska W., VanHooke J., DeLuca H. F., Yamada S.
RT Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain
RL Proc. Natl. Acad. Sci. USA 97:1467-1472 (2000).
RN [13]; RE0016349.
RX PUBMED: 9632111.
RA Hsieh J. C., Shimizu Y., Minoshima S., Shimizu N., Haussler C. A., Jurutka P. W., Haussler M. R.
RT Novel nuclear localization signal between the two DNA-binding zinc fingers in the human vitamin D receptor
RL J. Cell. Biochem. 70:94-109 (1998).
RN [14]; RE0016356.
RX PUBMED: 10828304.
RA Yamada S., Yamamoto K., Masuno H.
RT Structure-function analysis of vitamin D and VDR model
RL Curr. Pharm. Des. 6:733-748 (2000).
RN [15]; RE0016437.
RX PUBMED: 9632709.
RA Baudino T. A., Kraichely D. M., Jefcoat SC J. r., Winchester S. K., Partridge N. C., MacDonald P. N.
RT Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription
RL J. Biol. Chem. 273:16434-16441 (1998).
RN [16]; RE0017159.
RX PUBMED: 11500934.
RA Krill D., DeFlavia P., Dhir R., Luo J., Becich M. J., Lehman E., Getzenberg R. H.
RT Expression patterns of vitamin D receptor in human prostate
RL J. Cell. Biochem. 82:566-572 (2001).
RN [17]; RE0017308.
RX PUBMED: 9115274.
RA Thenot S., Henriquet C., Rochefort H., Cavailles V.
RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
RL J. Biol. Chem. 272:12062-12068 (1997).
RN [18]; RE0031743.
RX PUBMED: 11792709.
RA Yang F., Li X., Sharma M., Sasaki C. Y., Longo D. L., Lim B., Sun Z.
RT Linking beta-catenin to androgen-signaling pathway.
RL J. Biol. Chem. 277:11336-44 (2002).
RN [19]; RE0035930.
RX PUBMED: 15456860.
RA Paredes R., Arriagada G., Cruzat F., Villagra A., Olate J., Zaidi K., van Wijnen A., Lian J. B., Stein G. S., Stein J. L., Montecino M.
RT Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells.
RL Mol. Cell. Biol. 24:8847-8861 (2004).
RN [20]; RE0047287.
RX PUBMED: 10707958.
RA Jurutka P. W., Remus L. S., Whitfield G. K., Thompson P. D., Hsieh J. C., Zitzer H., Tavakkoli P., Galligan M. A., Dang H. T., Haussler C. A., Haussler M. R.
RT The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB
RL Mol. Endocrinol. 14:401-20 (2000).
RN [21]; RE0047290.
RX PUBMED: 7876247.
RA MacDonald P. N., Sherman D. R., Dowd D. R., Jefcoat S. C. Jr, DeLisle R. K.
RT The vitamin D receptor interacts with general transcription factor IIB
RL J. Biol. Chem. 270:4748-52 (1995).
RN [22]; RE0047333.
RX PUBMED: 12847098.
RA Hsieh J. C., Sisk J. M., Jurutka P. W., Haussler C. A., Slater S. A., Haussler M. R., Thompson C. C.
RT Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.
RL J. Biol. Chem. 278:38665-38674 (2003).
RN [23]; RE0047375.
RX PUBMED: 11891224.
RA Gonzalez M. M., Carlberg C.
RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
RL J. Biol. Chem. 277:18501-18509 (2002).
RN [24]; RE0048867.
RX PUBMED: 16195230.
RA Shen Q., Christakos S.
RT The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin.
RL J. Biol. Chem. 280:40589-40598 (2005).
RN [25]; RE0051282.
RX PUBMED: 15489543.
RA Adachi R., Honma Y., Masuno H., Kawana K., Shimomura I., Yamada S., Makishima M.
RT Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.
RL J. Lipid Res. 46:46-57 (2005).
RN [26]; RE0051726.
RX PUBMED: 8948643.
RA Nayeri S., Kahlen J. P., Carlberg C.
RT The high affinity ligand binding conformation of the nuclear 1,25-dihydroxyvitamin D3 receptor is functionally linked to the transactivation domain 2 (AF-2).
RL Nucleic Acids Res. 24:4513-4518 (1996).
RN [27]; RE0051730.
RX PUBMED: 17368182.
RA Arriagada G., Paredes R., Olate J., van Wijnen A., Lian J. B., Stein G. S., Stein J. L., Onate S., Montecino M.
RT Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators.
RL J. Steroid Biochem. Mol. Biol. 103:425-429 (2007).
RN [28]; RE0051749.
RX PUBMED: 1656468.
RA Hsieh J. C., Jurutka P. W., Galligan M. A., Terpening C. M., Haussler C. A., Samuels D. S., Shimizu Y., Shimizu N., Haussler M. R.
RT Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.
RL Proc. Natl. Acad. Sci. USA 88:9315-9319 (1991).
RN [29]; RE0051786.
RX PUBMED: 10224118.
RA Jimenez-Lara A. M., Aranda A.
RT Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.
RL J. Biol. Chem. 274:13503-13510 (1999).
RN [30]; RE0051863.
RX PUBMED: 9359430.
RA Nayeri S., Carlberg C.
RT Functional conformations of the nuclear 1alpha,25-dihydroxyvitamin D3 receptor.
RL Biochem. J. 327:561-568 (1997).
RN [31]; RE0051975.
RX PUBMED: 11075811.
RA Liu Y. Y., Nguyen C., Peleg S.
RT Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor.
RL Mol. Endocrinol. 14:1776-1787 (2000).
RN [32]; RE0051998.
RX PUBMED: 17595320.
RA Schedlich L. J., Muthukaruppan A., O'Han M. K., Baxter R. C.
RT Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts.
RL Mol. Endocrinol. 21:2378-2390 (2007).
RN [33]; RE0053334.
RX PUBMED: 16269453.
RA Xie Z., Chang S., Oda Y., Bikle D. D.
RT Hairless suppresses vitamin D receptor transactivation in human keratinocytes.
RL Endocrinology 147:314-323 (2006).
RN [34]; RE0053588.
RX PUBMED: 17974568.
RA Maiti A., Hait N. C., Beckman M. J.
RT Extracellular calcium-sensing receptor activation induces vitamin D receptor levels in proximal kidney HK-2G cells by a mechanism that requires phosphorylation of p38alpha MAPK.
RL J. Biol. Chem. 283:175-183 (2008).
RN [35]; RE0053648.
RX PUBMED: 11719366.
RA Ward J. O., McConnell M. J., Carlile G. W., Pandolfi P. P., Licht J. D., Freedman L. P.
RT The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor.
RL Blood 98:3290-3300 (2001).
RN [36]; RE0053776.
RX PUBMED: 16322098.
RA Seoane S., Perez-Fernandez R.
RT The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor.
RL Mol. Endocrinol. 20:735-748 (2006).
RN [37]; RE0053800.
RX PUBMED: 17456792.
RA Seoane S., Ben I., Centeno V., Perez-Fernandez R.
RT Cellular expression levels of the vitamin D receptor are critical to its transcriptional regulation by the pituitary transcription factor Pit-1.
RL Mol. Endocrinol. 21:1513-1525 (2007).
RN [38]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [39]; RE0055471.
RX PUBMED: 19054766.
RA Dhawan P., Weider R., Christakos S.
RT CCAAT Enhancer-binding Protein {alpha} Is a Molecular Target of 1,25-Dihydroxyvitamin D3 in MCF-7 Breast Cancer Cells.
RL J. Biol. Chem. 284:3086-3095 (2009).
RN [40]; RE0070207.
RX PUBMED: 20733005.
RA An B. S., Tavera-Mendoza L. E., Dimitrov V., Wang X., Calderon M. R., Wang H. J., White J. H.
RT Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.
RL Mol. Cell. Biol. 30:4890-4900 (2010).
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