AC T02738
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ID T02738
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DT 01.06.1999 (created); mpr.
DT 28.01.2009 (updated); jag.
CO Copyright (C), QIAGEN.
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FA SHP
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SY NR0B2; short heterodimer partner; SHP-1; small heterodimer partner.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002556 NR0B2; HGNC: NR0B2.
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CL C0002; CC (rec); 2.1.7.0.2.
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SF orphan nuclear receptor, contains dimerization and ligand-binding domain but lacks the conserved DNA-binding domain;
SF interacts with several retinoid receptors, the thyroid hormone receptor, and the orphan receptor MB67;
SF fully intact SHP protein is required for its interaction with FTF [4];
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FF It has inhibitory effect on LXR/RXR-mediated expression of SREBP-1c T01558, and dexamethasone-stimulated expression of SREBP-2 T01560, both of which are co-activated by PGC-1alpha T05295 [5];
FF repressor of nuclear receptor-dependent signaling pathways [1];
FF represses expression of the rat CYP7A1G001194 by inhibiting transcriptional activity of FTF T02770 [3];
FF represses FTF-dependent activation of the rat CYP8B1 by preventing FTF binding to its site [4];
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IN T02765 ERR1; human, Homo sapiens.
IN T03828 HNF-4alpha; human, Homo sapiens.
IN T02430 HNF-4gamma; human, Homo sapiens.
IN T22942 hnRNPA1; human, Homo sapiens.
IN T02770 LRH-1; human, Homo sapiens.
IN T02745 PPARdelta; human, Homo sapiens.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T04597 SKIP; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
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DR TRANSPATH: MO000026713.
DR UniProtKB: Q15466;
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RN [1]; RE0006318.
RX PUBMED: 8650544.
RA Seol W., Choi H. S., Moore D. D.
RT An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors
RL Science 272:1336-1339 (1996).
RN [2]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [3]; RE0016409.
RX PUBMED: 11030332.
RA Goodwin B., Jones S. A., Price R. R., Watson M. A., McKee D. D., Moore L. B., Galardi C., Wilson J. G., Lewis M. C., Roth M. E., Maloney P. R., Willson T. M., Kliewer S. A.
RT A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
RL Mol. Cell 6:517-526 (2000).
RN [4]; RE0018060.
RX PUBMED: 11574686.
RA del Castillo-Olivares A., Gil G.
RT Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism.
RL Nucleic Acids Res. 29:4035-4042 (2001).
RN [5]; RE0048535.
RX PUBMED: 16282353.
RA Oberkofler H., Klein K., Felder T. K., Krempler F., Patsch W.
RT Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells.
RL Endocrinology 147:966-976 (2006).
RN [6]; RE0051082.
RX PUBMED: 17895379.
RA Sanyal S., Bavner A., Haroniti A., Nilsson L. M., Lundasen T., Rehnmark S., Witt M. R., Einarsson C., Talianidis I., Gustafsson J. A., Treuter E.
RT Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.
RL Proc. Natl. Acad. Sci. USA 104:15665-15670 (2007).
RN [7]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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